Drugs & Supplements

Active ingredient: Omeprazole

Omeprazole

Pharmacological action

omeprazole is an inhibitor of H+ K+ ATPase. This medication inhibits the activity of H+-K+-ATPase in gastric parietal cells and thus blocks the final stage of hydrochloric acid secretion. This leads to a reduction in basal and stimulated secretion, regardless of the nature of the stimulus. Due to the reduction of acid secretion omeprazole reduces or normalizes the effects of acid in the esophagus in patients with reflux esophagitis.

omeprazole has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori when omeprazole used with antibiotics allows to quickly arrest the symptoms, to take a high degree of healing of damaged mucosa and persistent long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.

Pharmacokinetics

After oral administration omeprazole is rapidly absorbed from the gastrointestinal tract. This drug penetrates the parietal cells of gastric mucosa. Plasma protein binding is about 95% (predominantly albumin). omeprazole is biotransformed in the liver. Excreted by the kidneys - 72-80%, in the faeces - about 20%. T1/2 is 0.5-1 h. In patients with chronic liver diseases T1/2 increases up to 3 hours.

Why is omeprazole prescribed?

Gastric ulcer and duodenal ulcer in acute phase (including associated with Helicobacter pylori), reflux esophagitis, Zollinger-Ellison syndrome, erosive and ulcerative lesions of gastric and duodenal ulcers associated with taking NSAIDs.

Dosage and administration

The dosing regimen of omeprazole is individual. When this medication is administered orally of the single dose is 20-40 mg. The daily dose is 20-80 mg, the frequency of use is 1-2 times / day. The duration of treatment is 2-8 weeks.

omeprazole side effects, adverse reactions

Digestive system: rarely - nausea, diarrhea, constipation, abdominal pain, flatulence.

CNS: rarely - headache, dizziness, weakness.

Hemopoietic system: in some cases - anemia, eosinopenia, neutropenia, thrombocytopenia.

Urinary system: in some cases - hematuria, proteinuria.

Musculoskeletal system: in some cases - arthralgia, muscle weakness, myalgia.

Allergic reactions: rarely - skin rash.

omeprazole contraindications

Chronic liver disease (including in history), hypersensitivity to omeprazole.

Using during pregnancy and breastfeeding

In the absence of clinical experience with omeprazole it is not recommended to use this drug during pregnancy. If necessary to use during omeprazole lactation it should been solve the issue of termination of breastfeeding.

Category effects on the fetus by FDA - C.

Special instructions

Before the treatment with omeprazole it is necessary to exclude the possibility of a malignant process (especially gastric ulcer) because omeprazole treatment can mask symptoms and delay the correct diagnosis.

Therapy with omeprazole may affects results of laboratory studies of liver and gastrin concentrations in blood plasma.

Due to lack of experience in clinical application of omeprazole this medicine is not recommended for children.

omeprazole drug interactions

This medication alters the bioavailability of any drug, absorption depends on pH (ketoconazole, iron salts, etc.). omeprazole slows down the elimination of drugs metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin, etc.).

omeprazole enhances the action of coumarin and diphenine, does not change - NSAIDs. This drug increases (relative) the concentration of clarithromycin in the blood; may increases the leukopenic and thrombocytopenic effects of depressants hematopoiesis drugs. Substance for intravenous infusion is compatible only with saline and dextrose (using other solvents may decrease the stability of omeprazole due to changes in pH of infusion medium).

omeprazole in case of emergency / overdose

Symptoms: dry mouth, nausea, blurred vision, headache, increased sweating, flushing, tachycardia, drowsiness, confusion.

Treatment: symptomatic, dialysis is ineffective.

Omeprazole available forms, composition, doses:

Price
Apo-Omeprazole 20 mg Capsule/Sustained Release Tablet1.15 USD
CVS Pharmacy omeprazole dr 20 mg tablet0.53 USD
Capsules, Delayed Release; Oral; Omeprazole 10 mg
Capsules, Delayed Release; Oral; Omeprazole 20 mg
Capsules, Delayed Release; Oral; Omeprazole 40 mg
Capsules, Delayed Release; Oral; Omeprazole Magnesium 10 mg
Capsules, Delayed Release; Oral; Omeprazole Magnesium 20 mg
Capsules, Delayed Release; Oral; Omeprazole Magnesium 40 mg
Capsules, Gastro-Resistant; Oral; Omeprazole 10 mg
Capsules, Gastro-Resistant; Oral; Omeprazole 20 mg
Capsules; Oral; Omeprazole 10 mg
Capsules; Oral; Omeprazole 20 mg
Capsules; Oral; Omeprazole 40 mg
Losec (Sustained-Release Capsule) 20 mg Capsule/Sustained Release Tablet1.24 USD
Losec (Sustained-Release Tablet) 10 mg Capsule/Sustained Release Tablet1.97 USD
Losec (Sustained-Release Tablet) 20 mg Capsule/Sustained Release Tablet2.48 USD
Mylan-Omeprazole 10 mg Capsule/Sustained Release Tablet0.86 USD
Mylan-Omeprazole 20 mg Capsule/Sustained Release Tablet1.15 USD
Omeprazole 10 mg Delayed Release Capsule3.13 USD
Omeprazole 20 mg Delayed Release Capsule4.32 USD
Omeprazole 28 20 mg Enteric Coated Tabs Box25.99 USD
Omeprazole 40 mg Delayed Release Capsule7.69 USD
Omeprazole dr 20 mg tablet0.66 USD
Omeprazole powder5.05 USD
Pms-Omeprazole (Delayed Release Tablet) 20 mg Capsule/Sustained Release Tablet1.15 USD
Pms-Omeprazole (Sustained-Release Capsule) 20 mg Capsule/Sustained Release Tablet1.15 USD
PriLOSEC 30 10 mg Delayed Release Capsule Bottle174.37 USD
PriLOSEC 30 20 mg Delayed Release Capsule Bottle459.99 USD
PriLOSEC 40 mg Delayed Release Capsule9.59 USD
PriLOSEC OTC 14 20 mg Enteric Coated Tabs Box19.99 USD
Prilosec 20 mg capsule dr6.15 USD
Prilosec dr 10 mg capsule5.59 USD
Prilosec dr 20 mg capsule6.24 USD
Prilosec dr 40 mg capsule9.22 USD
Prilosec otc 20 mg tablet0.76 USD
Ratio-Omeprazole (Sustained-Release Tablet) 20 mg Capsule/Sustained Release Tablet1.15 USD
Sandoz Omeprazole (Sustained-Release Capsule) 10 mg Capsule/Sustained Release Tablet0.86 USD
Sandoz Omeprazole (Sustained-Release Capsule) 20 mg Capsule/Sustained Release Tablet1.15 USD
Tablets, Delayed Release; Oral; Omeprazole 20 mg
Zegerid 20 mg capsule7.19 USD
Zegerid 30 20-1680 mg Packets Packet224.27 USD
Zegerid 30 40-1680 mg Packets Packet224.27 USD
Zegerid 40 mg capsule6.46 USD
Zegerid 40-1100 mg capsule7.48 USD
Zegerid otc 20-1100 mg capsule0.78 USD

Indications and Usages:

ATC codes:

ICD-10 codes:

Omeprazole destination | category:


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