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DRUGS & SUPPLEMENTS
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Zopiclone
When are you taking this medicine? |
Zopiclone uses
Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone’s benzodiazepine pharmacological properties it also has some barbiturate like properties.
Indication: For the short-term treatment of insomnia.
Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia. While Zopiclone is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex. Subunit modulation of the GABABZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor.
Pharmacological action
Zopiclone is a sleeping drug from group of cyclopyrrolone derivatives. This drug is "non benzodiazepine" agonist of benzodiazepine receptors. Zopiclone also has sedative, anxiolytic, muscle-relaxing center, anticonvulsant and amnesic properties. Like a derivative of benzodiazepine Zopiclone enhances GABA-ergic processes in the brain, interacting with the benzodiazepine receptors, as a result of the increased sensitivity of GABA-receptors to the neurotransmitter. However, Zopiclone apparently interacts with other parts of the benzodiazepine receptor than benzodiazepines.
Zopiclone reduced sleep time, reduces the number of nighttime awakenings, increases total sleep time. This medication almost has no effect on sleep structure, does not reduce significantly the amount of REM sleep. Consequences of the phenomenon of waking up are missing or expressed little. Readmission Zopiclone are not accompanied by cumulation.
Pharmacokinetics
Zopiclone rapidly and completely absorbed from the gastrointestinal tract. Cmax achieved within 1-3 hours. Zopiclone easily passes through gistogematicheskie barriers including the BBB and it is distributed in organs and tissues including brain. T1/2 is 5.5-6 hours, not accumulates.
Why is Zopiclone prescribed?
Sleep disturbance, transient, situational or chronic insomnia; sleep disturbances in mental disorders, bronchial asthma with nocturnal seizures (in combination with single dose daily dose of theophylline).
Dosage and administration
The average therapeutic dose of Zopiclone is 7.5 mg orally at night, in cases of severe insomnia the dose can be increased up to 15 mg. In elderly patients, as well as abnormal liver function is used 3.75 mg.
Zopiclone side effects, adverse reactions
Digestive system: a feeling of bitter or metallic taste in the mouth, dry mouth, nausea, and vomiting.
CNS: dizziness, headache, drowsiness, confusion, anterograde amnesia, hallucinations, nightmares.
Dermatologic reactions: skin rash.
Zopiclone contraindications
Severe respiratory failure, pregnancy, lactation, children and teens under 15 years old, hypersensitivity to Zopiclone.
Using during pregnancy and breastfeeding
Zopiclone is contraindicated during pregnancy (especially in I and III trimester) and lactation (breastfeeding). If a woman uses Zopiclone in III trimester of pregnancy there are possible violations of the nervous system in the newborn, the emergence of withdrawal syndrome. If the woman is prescribed by a doctor took Zopiclone immediately prior to labor and delivery, it needs a constant medical surveillance for the newborn. At the time of treatment it should be stoped breastfeeding (zopiclone penetrates into breast milk).
Special instructions
With caution use in patients with severe liver failure.
Risk of drug dependence is minimal if the duration of Zopiclone did not exceed 4 weeks. However, the potential danger of Zopiclone dependence to exist.
During the period of treatment patients should to exclude the use of alcohol.
On the next day after taking the drug it should be cautious to drive and operate machinery.
Zopiclone drug interactions
Simultaneous administration of Zopiclone with trimipramine reduces the concentration of trimipramine in plasma and its effect.
Zopiclone increases the influence of CNS depressants.
Zopiclone in case of emergency / overdose
Symptoms: CNS depression of varying severity (from drowsiness to loss of consciousness).
Treatment: gastric lavage, taking activated charcoal, if necessary - symptomatic therapy. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital). Hemodialysis is ineffective.
Zopiclone pharmaceutical active ingredients containing related brand and generic drugs:
Zopiclone available forms, composition, doses:
| Price | |
| Apo-Zopiclone 5 mg Tablet | 0.23 USD |
| Apo-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Co Zopiclone 5 mg Tablet | 0.23 USD |
| Co Zopiclone 7.5 mg Tablet | 0.49 USD |
| Imovane 5 mg Tablet | 1.11 USD |
| Imovane 7.5 mg Tablet | 1.41 USD |
| Mylan-Zopiclone 5 mg Tablet | 0.23 USD |
| Mylan-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Novo-Zopiclone 5 mg Tablet | 0.23 USD |
| Novo-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Nu-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Pms-Zopiclone 5 mg Tablet | 0.23 USD |
| Pms-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Ran-Zopiclone 5 mg Tablet | 0.23 USD |
| Ran-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Ratio-Zopiclone 5 mg Tablet | 0.23 USD |
| Ratio-Zopiclone 7.5 mg Tablet | 0.49 USD |
| Rhovane 7.5 mg Tablet | 0.49 USD |
| Sandoz Zopiclone 5 mg Tablet | 0.23 USD |
| Sandoz Zopiclone 7.5 mg Tablet | 0.49 USD |
| Tablets, Film-Coated; Oral; Zopiclone 7.5 mg | |
| Tablets; Oral; Zopiclone 5 mg | |
| Tablets; Oral; Zopiclone 7.5 mg | |
| Zopiclone 5 mg Tablet | 0.23 USD |
| Zopiclone 7.5 mg Tablet | 0.49 USD |
Zopiclone destination | category:
Zopiclone Anatomical Therapeutic Chemical codes:
Zopiclone pharmaceutical companies:
References
- "zopiclone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "zopiclone". http://www.drugbank.ca/drugs/DB0119... (accessed August 28, 2018).
- "zopiclone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Zopiclone?Depending on the reaction of the Zopiclone after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zopiclone not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Zopiclone addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Zopiclone, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zopiclone consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Zopiclone useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
Visitor reported side effects
No survey data has been collected yetOne visitor reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Zopiclone is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% | |
Two visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Zopiclone drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Zopiclone is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 2 | 100.0% | |
Three visitors reported doses
What is the dose of Zopiclone drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 6-10mg | 2 | 66.7% | |
| 1-5mg | 1 | 33.3% | |
One visitor reported time for results
What is the time duration Zopiclone drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Zopiclone drug. The time needed to show improvement in health condition after using the medicine Zopiclone need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 1 day | 1 | 100.0% | |
Visitor reported administration
No survey data has been collected yetOne visitor reported age
| Visitors | % | ||
|---|---|---|---|
| 46-60 | 1 | 100.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology