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DRUGS & SUPPLEMENTS
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When are you taking this medicine? |
Ramipril:
Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals belongs to the class of drugs classified as ACE inhibitors or Angiotensin-Converting-Enzyme inhibitor.
This product is a drug prescribed for the treatment of hypertension or high blood pressure, and for the prevention of heart failures succeeding heart attacks. Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals is also used for the prevention of heart attacks, stroke and other heart related problems.
The medication is major allergen especially to patients who have had histories of allergies. Ask for a skin test from your doctor if you are a person prone to allergies and more importantly if you are allergic to the components of Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals.
Before taking the medicine, inform your doctor if you have:
liver disease
kidney disease
And if you are on a salt restricted diet or taking salt substitutes, your doctor may lower you Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals dosage or even forbid you to take the drug.
Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals is also a grudge belonging to the pregnancy category D, which means that this medicine is a sure cause of birth defects in babies and may even cause death in the 2nd and third trimester of pregnancy.
The components of Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals are also passed through breast milk and the degree of harmful effects on the nursing infant is not known. Talk to your doctor first before deciding to take Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals if you are breast feeding.
Never take Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals when performing tasks that require mental and physical alertness such as driving or operating any kind of machinery. This medication is a powerful cause of drowsiness and dizziness.
Always maintain proper hydration when taking this medicine. Lack of fluids may cause low blood pressure and may enhance dizziness and fainting.
This medicine should be taken exactly as it is prescribed by your doctor.
Each dose must be taken with a full glass of water of about 6-8 ounces.
The intake of Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals can be with or without food.
Never stop medication without first consulting your doctor even if you begin to feel better, it still important that your termination of use of this medicine must be properly supervised by your doctor.
The dosage of Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals can only be effectively determined by your doctor.
If symptoms of overdose such as extreme drowsy and dizzy feeling, weakening, fainting and fatigue settles in, immediately seek medical help.
Do not take double doses of Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals; instead, skip the dose you missed especially if it near the time for the next dose.
Possible side effects of Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals may include:
allergic reactions
difficulty in urinating
arrhythmia
changes in heartbeat
chest pains
severe drowsiness
sore throat
fever
headache
fatigue
dry tickling cough
nausea
vomiting
diarrhea
anxiety and depression
If you experience any of these side effects and if they become bothersome and intolerable, consult your doctor.
This drug may react with drugs that contain potassium and potassium supplements such as K-Dur and Klor-Con.
Diuretics may also not work well with Valent R (Ramipril) Karnataka Antibiotics & Pharmaceuticals as well as water pills such as Lasix, Bumex and Lozol.
Valsartan:
Valent R is an antihypertensive drug. This medication is a specific antagonist of angiotensin II. It has a selective antagonistic effect on AT1-receptors, which are responsible for implementing the effects of angiotensin II.
Due to the blockade of AT1-receptors the plasma concentrations of angiotensin II increased, which may stimulate the unblocked AT2-receptors. This medicine has no agonistic activity against AT1-receptor. The affinity of Valent R (Valsartan) for AT1-receptors in about 20 000 times higher than that of AT2-receptors.
Valent R (Valsartan) does not inhibit ACE. This drug has no interaction and does not block other hormone receptors or ion channels important for regulation of the cardiovascular system.
This medication has no effect on total cholesterol, triglycerides, glucose and uric acid in blood plasma.
A start of antihypertensive action of Valent R (Valsartan) after its oral administration in a single dose occurs within 2 h after administration, the maximum effect is achieved within 4-6 h.
After oral administration Valent R (Valsartan) is rapidly absorbed from the gastrointestinal tract, the extent of absorption is characterized by individual differences. The absolute bioavailability is average 23%.
In course of treatment with this medication there were not noted changes of pharmacokinetic parameters.
When administered with food Valent R (Valsartan) AUC decreased by 48%, with approximately 8 hours after administration of Valent R (Valsartan) in plasma concentrations of the same in patients taking it with food and fasting. AUC decrease is not accompanied by clinically significant reduction in therapeutic effect.
When you receive Valent R (Valsartan) 1 time / day the accumulation is expressed only slightly. The concentration of Valent R (Valsartan) in the blood plasma of women and men were equal. The binding with plasma proteins, primarily to albumin is 94-97%.
The plasma clearance of Valent R (Valsartan) is about 2 L / h. This medication is excreted in the feces 70% and in urine 30%, largely unchanged.
When biliary cirrhosis or biliary obstruction AUC of Valent R (Valsartan) is increased approximately 2-fold.
A treatment of hypertension. A treatment of chronic heart failure (II-IV functional class classification NYHA) in patients receiving conventional therapy with diuretics, digitalis preparations, as well as ACE inhibitors or beta-blockers.
Valent R is taken orally in dose 80 mg daily 1 time / day or 40 mg 2 times / day. In the absence of adequate effect the daily dose may be gradually increased. The maximum daily dose is 320 mg in 2 divided doses.
Cardiovascular system: hypotension, postural dizziness, postural hypotension.
CNS: dizziness, headache.
Digestive system: diarrhea, nausea, increased bilirubin levels.
Urinary system: rarely - renal failure, increased creatinine and BUN (especially in chronic heart failure).
Metabolic: hyperkalemia.
Hematopoietic system: neutropenia, a decrease in hemoglobin and hematocrit.
Allergic reactions: rarely - angioedema, rash, pruritus, serum sickness, vasculitis.
Other: fatigue, weakness, cough, sore throat, increased risk of viral infections.
Pregnancy, hypersensitivity to Valent R (Valsartan).
Valent R is contraindicated during pregnancy. It is not known whether Valent R (Valsartan) is allocated to breast milk in humans. Use during lactation (breastfeeding) is not recommended.
Experimental studies have shown that this medication is excreted in breast milk of rats.
Category of the fetus by FDA - D.
When hyponatremia and / or reduction of the BCC, as well as during treatment with high doses of diuretics, Valent R (Valsartan), in rare cases can cause pronounced hypotension.
Before starting treatment it should be the correction of violations of water-salt metabolism.
In patients with renovascular hypertension, which developed secondary to renal artery stenosis, in the period of treatment should regularly monitor the level of urea and creatinine in serum. There is no data on the safety of patients with CC than 10 ml / min.
With great caution use in patients with impaired patency of the biliary tract.
Due to inhibition of the RAAS in patients predisposed to changes in renal function.
With use of ACE inhibitors and angiotensin receptor antagonists in patients with chronic heart failure severity of the observed oliguria and / or increase azotemia, rarely developed acute renal failure with risk of death.
Safety and efficacy of Valent R (Valsartan) in children has not been established.
If use Valent R (Valsartan) it is recommended a caution when driving and management mechanisms.
When this drug applied simultaneously with:
- diuretics in high doses it may developed hypotension.
- potassium-sparing diuretics, heparin, dietary supplements or salt substitutes containing potassium may develop hyperkalemia.
- indomethacin may decrease the antihypertensive action of Valent R (Valsartan).
- lithium carbonate, described the case of lithium toxicity.
Symptoms: hypotension, tachycardia or bradycardia.
Treatment: symptomatic therapy, dialysis is not effective.
Depending on the reaction of the Valent R after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Valent R not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Valent R addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology