Phenadex Cough / Cold

Dextromethorphan Hydrobromide:

• Pharmacological action
• Pharmacokinetics
• Why is Phenadex Cough / Cold prescribed?
• Dosage and administration
• Phenadex Cough / Cold (Dextromethorphan Hydrobromide) side effects, adverse reactions
• Phenadex Cough / Cold contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Phenadex Cough / Cold drug interactions
• Phenadex Cough / Cold in case of emergency / overdose
• Phenadex Cough / Cold (Dextromethorphan Hydrobromide) reviews

Pharmacological action

Phenadex Cough / Cold is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Phenadex Cough / Cold (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Phenadex Cough / Cold (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Phenadex Cough / Cold (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Phenadex Cough / Cold (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Phenadex Cough / Cold (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Phenadex Cough / Cold (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. C_max of Phenadex Cough / Cold (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Phenadex Cough / Cold prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Phenadex Cough / Cold prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Phenadex Cough / Cold (Dextromethorphan Hydrobromide) side effects, adverse reactions

Drowsiness, nausea, dizziness.

Phenadex Cough / Cold contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Phenadex Cough / Cold (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Phenadex Cough / Cold (Dextromethorphan Hydrobromide) with impaired liver function.

Phenadex Cough / Cold drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Phenadex Cough / Cold (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Phenadex Cough / Cold (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Phenadex Cough / Cold in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Guaifenesin:

• Phenadex Cough / Cold (Guaifenesin) reviews

Indication: Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

Phenadex Cough / Cold (Guaifenesin) is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, Phenadex Cough / Cold (Guaifenesin) increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.

Phenylpropanolamine Hydrochloride:

• Phenadex Cough / Cold (Phenylpropanolamine Hydrochloride) reviews

Indication: For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.

Phenadex Cough / Cold (Phenylpropanolamine Hydrochloride) (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Phenadex Cough / Cold (Phenylpropanolamine Hydrochloride) is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing Phenadex Cough / Cold (Phenylpropanolamine Hydrochloride), due to an increased risk of hemorrhagic stroke in women who used Phenadex Cough / Cold (Phenylpropanolamine Hydrochloride).