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DRUGS & SUPPLEMENTS
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Ladose
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Ladose uses
Pharmacological action
Ladose is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Ladose is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Ladose apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Ladose does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.
Pharmacokinetics
Ladose absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Ladose easily penetrates through the BBB.
Ladose metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.
T1/2 of Ladose is 2-3 days, norfluoxetine - 7-9 days.
Why is Ladose prescribed?
Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.
Dosage and administration
The initial dose of Ladose is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.
The maximum oral daily dose for adults is 80 mg.
Ladose side effects, adverse reactions
CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.
Digestive system: diarrhea, nausea.
Metabolism: increased sweating, hypoglycemia, hyponatremia.
Reproductive system: decreased libido.
Allergic reactions: skin rash, itching.
Other: pain in joints and muscles, shortness of breath, increased body temperature.
Ladose contraindications
Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Ladose.
Using during pregnancy and breastfeeding
Ladose is contraindicated during pregnancy and lactation.
Special instructions
Ladose should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.
Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Ladose increases the risk of epileptic seizures.
With the simultaneous application of Ladose and electroconvulsive therapy may develop prolonged seizures.
Ladose can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Ladose before therapy MAO inhibitors should not be less than 5 weeks.
Elderly patients need correction of dosing regimen.
Safety of Ladose in children has not been established.
During the period of treatment it needed to avoid use alcohol.
During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.
Ladose drug interactions
Simultaneous administration of Ladose with:
Ladose in case of emergency / overdose
Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Ladose (in combination with maprotiline, codeine, temazepam).
Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.
Ladose pharmaceutical active ingredients containing related brand and generic drugs:
Ladose available forms, composition, doses:
Ladose destination | category:
Ladose Anatomical Therapeutic Chemical codes:
Ladose pharmaceutical companies:
References
- Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "fluoxetine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "fluoxetine". http://www.drugbank.ca/drugs/DB0047... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Ladose?Depending on the reaction of the Ladose after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ladose not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Ladose addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Ladose, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ladose consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Ladose useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
Visitor reported side effects
No survey data has been collected yetOne visitor reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Ladose is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% | |
Four visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Ladose drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Ladose is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 4 | 100.0% | |
Five visitors reported doses
What is the dose of Ladose drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 11-50mg | 2 | 40.0% | |
| 201-500mg | 1 | 20.0% | |
| 1-5mg | 1 | 20.0% | |
| 6-10mg | 1 | 20.0% | |
Two visitors reported time for results
What is the time duration Ladose drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 month to notice the result from using Ladose drug. The time needed to show improvement in health condition after using the medicine Ladose need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 3 month | 1 | 50.0% | |
| 1 week | 1 | 50.0% | |
Two visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Ladose drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| Empty stomach | 1 | 50.0% | |
| After food | 1 | 50.0% | |
Two visitors reported age
| Visitors | % | ||
|---|---|---|---|
| 30-45 | 1 | 50.0% | |
| 16-29 | 1 | 50.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology