Flagyl I.V. RTU in plastic container

Flagyl I.V. RTU in plastic container uses

• Pharmacological action
• Pharmacokinetics
• Why is Flagyl I.V. RTU in plastic container prescribed?
• Dosage and administration
• Flagyl I.V. RTU in plastic container side effects, adverse reactions
• Flagyl I.V. RTU in plastic container contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Flagyl I.V. RTU in plastic container drug interactions
• Flagyl I.V. RTU in plastic container in case of emergency / overdose
• Flagyl I.V. RTU in plastic container reviews

Pharmacological action

Flagyl I.V. RTU in plastic container is an anti protozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive microorganisms. Active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, and obligate anaerobic bacteria.

Aerobic bacteria are resistant to Flagyl I.V. RTU in plastic container.

In combination with amoxicillin Flagyl I.V. RTU in plastic container is active against Helicobacter pylori. It is believed that amoxicillin inhibits the development of resistance of Helicobacter pylori to Flagyl I.V. RTU in plastic container.

Pharmacokinetics

Flagyl I.V. RTU in plastic container well absorbed after oral administration. The bioavailability is 80%. Flagyl I.V. RTU in plastic container is distributed in tissues and body fluids. This medication crosses the placental barrier and the BBB. Binding to plasma proteins is 20%. Flagyl I.V. RTU in plastic container is metabolized in the liver by oxidation and binding to glucuronic acid. T_1/2 is 8 hours. This drug is excreted in the urine (60-80%) and feces (6-15%).

Why is Flagyl I.V. RTU in plastic container prescribed?

Trichomonazice vaginitis and urethritis in women, trichomonazice urethritis in men, giardiasis, amoebic dysentery, anaerobic infections caused by metronidazole-sensitive organisms, combination therapy of severe mixed aerobic-anaerobic infections. Preventing anaerobic infection in surgery. Chronic alcoholism.

Flagyl I.V. RTU in plastic container in combination with amoxicillin: chronic gastritis in acute phase, gastric ulcer and duodenal ulcer in acute phase, associated with Helicobacter pylori.

For external and topical use: treatment of acne vulgaris and pink, bacterial vaginosis, treatment of long-term healing of wounds and trophic ulcers.

Dosage and administration

Flagyl I.V. RTU in plastic container is administered for oral use for adults and children over 12 years in 7.5 mg / kg every 6 h or 250-750 mg 3-4 times / day. For children up to 12 years the dose is 5-16.7 mg / kg 3 times / day. For IV injections for adults and children over 12 years starting dose is 15 mg / kg, followed by 7.5 mg / kg every 6 hours or depending on the etiology of the disease - by 500-750 mg every 8 hours. The duration of treatment and frequency of tests is determined individually.

Intravaginally - 500 mg 1 time a night.

In combination with amoxicillin (2.25 g / day) daily dose of Flagyl I.V. RTU in plastic container is 1.5 g; multiplicity of admission - 3 times / day. For patients with severe renal impairment (creatinine clearance less than 30 ml / min) and / or liver daily dose of Flagyl I.V. RTU in plastic container is 1 g (amoxicillin - 1.5 g / day), the multiplicity of the reception is 2 times / day. This medication takes for external and local use 2 times / day, doses are determined individually.

The maximum daily dose for adults when taken orally and IV is 4 g.

Flagyl I.V. RTU in plastic container side effects, adverse reactions

Digestive system: nausea, vomiting, anorexia, metallic taste in the mouth.

CNS and peripheral nervous system: headache, nervousness, irritability, insomnia, dizziness, ataxia, weakness, confusion, depression, peripheral neuropathy, seizures, hallucinations.

Allergic reactions: skin rash, itching, hives.

Hemopoietic system: leucopenia.

Local reactions: irritation.

Other: arthralgia, burning sensation in the urethra.

Flagyl I.V. RTU in plastic container contraindications

Organic CNS lesions, blood diseases, liver problems, I trimester of pregnancy, hypersensitivity to Flagyl I.V. RTU in plastic container.

Using during pregnancy and breastfeeding

Flagyl I.V. RTU in plastic container is rapidly crosses the placental barrier. In II and III trimester of pregnancy Flagyl I.V. RTU in plastic container is used only for health reasons.

Flagyl I.V. RTU in plastic container is excreted in breast milk. If necessary, use during lactation should solve the issue of termination of breastfeeding.

Special instructions

Patients should with careful use of Flagyl I.V. RTU in plastic container in liver diseases.

In combination with amoxicillin this medication is not recommended for patients younger than 18 years. During the treatment period it is necessary the regular control of pattern of peripheral blood.

During the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men patients should refrain from sexual activity, simultaneous treatment of both partners is mandatory.

During the taking of Flagyl I.V. RTU in plastic container there is a more dark staining of urine.

During treatment with Flagyl I.V. RTU in plastic container should avoid alcohol because to violations of the oxidation of alcohol can accumulate acetaldehyde. As a result may develop reactions similar to those characteristic of disulfiram.

Flagyl I.V. RTU in plastic container drug interactions

Simultaneous administration of Flagyl I.V. RTU in plastic container with: