EP-Koff

Dextromethorphan Hydrobromide:

• Pharmacological action
• Pharmacokinetics
• Why is EP-Koff prescribed?
• Dosage and administration
• EP-Koff (Dextromethorphan Hydrobromide) side effects, adverse reactions
• EP-Koff contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• EP-Koff drug interactions
• EP-Koff in case of emergency / overdose
• EP-Koff (Dextromethorphan Hydrobromide) reviews

Pharmacological action

EP-Koff is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. EP-Koff (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. EP-Koff (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. EP-Koff (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. EP-Koff (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. EP-Koff (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration EP-Koff (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. C_max of EP-Koff (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is EP-Koff prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years EP-Koff prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

EP-Koff (Dextromethorphan Hydrobromide) side effects, adverse reactions

Drowsiness, nausea, dizziness.

EP-Koff contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) EP-Koff (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered EP-Koff (Dextromethorphan Hydrobromide) with impaired liver function.

EP-Koff drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with EP-Koff (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) EP-Koff (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

EP-Koff in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Guaifenesin:

• EP-Koff (Guaifenesin) reviews

Indication: Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

EP-Koff (Guaifenesin) is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, EP-Koff (Guaifenesin) increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.