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DRUGS & SUPPLEMENTS
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Disipal
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Disipal uses
- Indications and usage
- Contraindications
- Warnings
- Precautions
- Pregnancy
- Pediatric use
- Adverse reactions
- Drug abuse and dependence
- Overdosage
- Dosage and administration
- How supplied
- Orphenadrine citrate er 100 mg tabs
INDICATIONS AND USAGE
Disipal citrate extended-release tablets, USP are indicated as an adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute painful musculo skeletal conditions.
CONTRAINDICATIONS
Contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction of the bladder neck, cardio-spasm (megaesophagus) and myasthenia gravis.
Contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.
WARNINGS
Some patients may experience transient episodes of light-headedness, dizziness or syncope. Disipal citrate may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should therefore be cautioned accordingly.
PRECAUTIONS
Confusion, anxiety and tremors have been reported in few patients receiving propoxyphene and Disipal concomitantly. As these symptoms may be simply due to an additive effect, reduction of dosage and/or discontinuation of one or both agents is recommended in such cases.
Disipal citrate should be used with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency, cardiac arrhythmias.
Safety of continuous long-term therapy with Disipal citrate has not been established. Therefore, if Disipal citrate is prescribed for prolonged use, periodic monitoring of blood, urine and liver function values is recommended.
PREGNANCY
Pregnancy Category C
Animal reproduction studies have not been conducted with Disipal citrate. It is also not known whether Disipal citrate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Disipal citrate should be given to a pregnant woman only if clearly needed.
PEDIATRIC USE
Safety and effectiveness in pediatric patients have not been established.
ADVERSE REACTIONS
Adverse reactions of Disipal citrate are mainly due to the mild anti-cholinergic action of Disipal citrate and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of Disipal tablets have been reported. No causal relationship has been established.
DRUG ABUSE AND DEPENDENCE
Disipal citrate has been chronically abused for its euphoric effects.[1] The mood elevating effects may occur at therapeutic doses of Disipal.[2]
OVERDOSAGE
Disipal citrate is toxic when overdosed and typically induces anti-cholinergic effects.[3] In a review of Disipal toxicity, the minimum lethal dose was found to be 2 to 3 grams for adults; however, the range of toxicity is variable and unpredictable.[4] Treatment for Disipal citrate overdose is evacuation of stomach contents (when necessary), charcoal at repeated doses, intensive monitoring and appropriate supportive treatment of any emergent anti-cholinergic effects.[5]
DOSAGE AND ADMINISTRATION
Adults-Two tablets per day; one in the morning and one in the evening.
HOW SUPPLIED
Product: 68151-1463
NDC: 68151-1463-0 1 TABLET in a PACKAGE
Disipal Citrate ER 100 mg tabs
Disipal pharmaceutical active ingredients containing related brand and generic drugs:
Disipal available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.