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DRUGS & SUPPLEMENTS
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Candistatin
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Candistatin uses
- Description
- Clinical pharmacology
- Indications and usage
- Contraindications
- Precautions
- Adverse reactions
- Overdosage
- Dosage and administration
- How supplied
DESCRIPTION
Candistatin, USP is an antimycotic polyene antibiotic obtained from Streptomyces noursei. Its structural formula:
- C47H75NO17 M.W. 926.13
Candistatin Tablets USP contain the inactive ingredients: Corn Starch, Povidone, Compressible Sugar, Microcrystalline Cellulose, Sodium Starch Glycolate, Talc, Magnesium Stearate, Purified Water, and Coloring.
Structural formula for Candistatin
CLINICAL PHARMACOLOGY
Pharmacokinetics
Gastrointestinal absorption of Candistatin is insignificant. Most orally administered Candistatin is passed unchanged in the stool. In patients with renal insufficiency receiving oral therapy with conventional dosage forms, significant plasma concentrations of Candistatin may occasionally occur.
Microbiology
Candistatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast like fungi. Candida albicans demonstrates no significant resistance to Candistatin in vitro on repeated subculture in increasing levels of Candistatin; other Candida species become quite resistant. Generally, resistance does not develop in vivo. Candistatin acts by binding to sterols in the cell membrane of susceptible Candida species with a resultant change in membrane permeability allowing leakage of intracellular components. Candistatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
INDICATIONS AND USAGE
Candistatin tablets are intended for the treatment of non-esophageal mucus membrane gastrointestinal candidiasis.
CONTRAINDICATIONS
Candistatin tablets are contraindicated in patients with a history of hypersensitivity to any of their components.
PRECAUTIONS
General
This medication is not to be used for the treatment of systemic mycoses. Discontinue treatment if sensitization or irritation is reported during use.
Carcinogenesis, Mutagenesis, Impairment of Fertility
No long-term animal studies have been performed to evaluate carcinogenic potential. There also have been no studies to determine mutagenicity or whether this medication affects fertility in males or females.
Pregnancy
Teratogenic Effects
Pregnancy Category C
Animal reproduction studies have not been conducted with Candistatin. It is also not known whether Candistatin can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Candistatin should be given to a pregnant woman only if clearly needed.
Nursing Mothers
It is not known whether Candistatin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Candistatin is administered to a nursing woman.
ADVERSE REACTIONS
Candistatin is well tolerated even with prolonged therapy. Oral irritation and sensitization have been reported .
Gastrointestinal
Diarrhea (including one case of bloody diarrhea), nausea, vomiting, gastrointestinal upset/disturbances.
Dermatologic
Rash, including urticaria has been reported rarely. Stevens-Johnson syndrome has been reported very rarely.
Other
Tachycardia, bronchospasm, facial swelling, and nonspecific myalgia have also been rarely reported.
OVERDOSAGE
Oral doses of Candistatin in excess of five million units daily have caused nausea and gastrointestinal upset. There have been no reports of serious toxic effects of superinfections (see CLINICAL PHARMACOLOGY, Pharmacokinetics).
DOSAGE AND ADMINISTRATION
The usual therapeutic dosage is one to two tablets (500,000 to 1,000,000 units Candistatin) three times daily. Treatment should generally be continued for at least 48 hours after clinical cure to prevent relapse.
HOW SUPPLIED
Candistatin Tablets USP, 500,000 Units are round, convex, brown, film-coated tablet debossed with 93 on one side and 983 on the reverse and are packaged in bottles of 100 tablets (NDC 0093-0983-01).
Store at 20° to 25°C (68° to 77°F).
Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).
Keep tightly closed.
KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.
Manufactured By:
TEVA CANADA LIMITED
Toronto, Canada M1B 2K9
Manufactured For:
TEVA PHARMACEUTICALS USA, INC.
North Wales, PA 19454
Rev. N 2/2016
NDC 0093-0983-01
Candistatin
Tablets USP
500,000 units (oral)
Rx only
100 TABLETS
TEVA
Candistatin pharmaceutical active ingredients containing related brand and generic drugs:
Candistatin available forms, composition, doses:
Candistatin destination | category:
Candistatin Anatomical Therapeutic Chemical codes:
Candistatin pharmaceutical companies:
References
- Dailymed."NYSTATIN TABLET, FILM COATED [TEVA PHARMACEUTICALS USA INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Candistatin?Depending on the reaction of the Candistatin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Candistatin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Candistatin addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Candistatin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Candistatin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Candistatin useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
One visitor reported side effects
Did you get side effects while taking the Candistatin drug, or were there no side effects?According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Candistatin medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
| Visitors | % | ||
|---|---|---|---|
| It has side effects | 1 | 100.0% | |
Visitor reported price estimates
No survey data has been collected yetOne visitor reported frequency of use
How often in a day do you take the medicine?Are you taking the Candistatin drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Candistatin is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 1 | 100.0% | |
Elenen visitors reported doses
What is the dose of Candistatin drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 1-5mg | 6 | 54.5% | |
| 11-50mg | 3 | 27.3% | |
| 101-200mg | 1 | 9.1% | |
| 6-10mg | 1 | 9.1% | |
Two visitors reported time for results
What is the time duration Candistatin drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 days to notice the result from using Candistatin drug. The time needed to show improvement in health condition after using the medicine Candistatin need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 3 days | 1 | 50.0% | |
| > 3 month | 1 | 50.0% | |
Two visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Candistatin drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| Empty stomach | 1 | 50.0% | |
| Before food | 1 | 50.0% | |
Nine visitors reported age
| Visitors | % | ||
|---|---|---|---|
| > 60 | 7 | 77.8% | |
| 6-15 | 1 | 11.1% | |
| 46-60 | 1 | 11.1% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology