Cafergot-PB Suppositories

Caffeine:

• Cafergot-PB Suppositories (Caffeine) reviews

Active ingredient (in each tablet)

Cafergot-PB Suppositories (Caffeine) 200mg

Purpose

Alertness aid

Use

• helps restore mental alertness or wakefulness when experiencing fatigue or drowsiness

Warnings

For occasional use only

Do not use

• in children under 12 years of age
• as a substitute for sleep

When using this product limit the use of Cafergot-PB Suppositories (Caffeine) containing medications, foods, or beverages because too much Cafergot-PB Suppositories (Caffeine) may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat. The recommended dose of this product contains about as much Cafergot-PB Suppositories (Caffeine) as a cup of coffee.

Stop use and ask a doctor if fatigue or drowsiness persists or continues to recur

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

• adults and children 12 years of age and over: take 1 tablet not more often than every 3 to 4 hours.

Other information

• store at room temperature
• avoid excessive heat (greater than 100°F) or humidity

Inactive ingredients

carnauba wax, colloidal silicon dioxide, D&C yellow #10 aluminum lake, dextrose, FD&C yellow #6 aluminum lake, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, starch, titanium dioxide

Questions or comments?

Call toll-free 1-855-874-0970 weekdays

Display Panel Cafergot-PB Suppositories (Caffeine): 16 ct. Package

Cafergot-PB Suppositories (Caffeine)^®

CAFFEINE ALERTNESS AID

16 TABLETS

200mg each

FUNCTIONAL Cafergot-PB Suppositories (Caffeine)^® for Mental Alertness

SAFE & EFFECTIVE

One tablet is equal to about a cup of coffee

Cafergot-PB Suppositories (Caffeine)^®

Making the Most of Every Day.^®

Tamper Evident Feature: individually sealed in foil for your protection. Do not

use if foil or plastic bubble is torn or punctured.

Vivarin®, Vivarin® and design, stylization and trade dress, and FUNCTIONAL

CAFFEINE® are registered trademarks of Meda AB.

Distributed by:

Meda Consumer Healthcare Inc.

Marietta, GA 30062 ©2011 Meda AB

www.vivarin.com

16 ct. Package

Display Panel Cafergot-PB Suppositories (Caffeine): 40 ct. Package

SAFE & EFFECTIVE

FUNCTIONAL Cafergot-PB Suppositories (Caffeine)^® for Mental Alertness

Cafergot-PB Suppositories (Caffeine)^®

Cafergot-PB Suppositories (Caffeine) ALERTNESS AID

40 Tablets

200mg each

FUNCTIONAL Cafergot-PB Suppositories (Caffeine)^® for Mental Alertness

Tamper Evident Feature: Individually sealed in foil for your protection. Do not use if foil or plastic bubble is torn or punctured.

VIVARIN® helps restore mental alertness or wakefulness when experiencing fatigue or drowsiness (FDA approved uses), so you can accomplish all the things you want to do and all the things you need to do.

Vivarin®, Vivarin® and design, stylization and trade dress, and FUNCTIONAL

CAFFEINE® are registered trademarks of Meda AB.

Made in the U.S.A.

Cafergot-PB Suppositories (Caffeine)^®

Making the Most of Every Day.^®

Distributed by:

Meda Consumer Healthcare Inc.

Marietta, GA 30062 ©2013 Meda AB

www.vivarin.com

40 ct. Package

Ergotamine Tartrate:

• Cafergot-PB Suppositories (Ergotamine Tartrate) reviews

Indication: For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".

Cafergot-PB Suppositories (Ergotamine Tartrate) is a vasoconstrictor and alpha adrenoreceptor antagonist. The pharmacological properties of Cafergot-PB Suppositories (Ergotamine Tartrate) are extremely complex; some of its actions are unrelated to each other, and even mutually antagonistic. The drug has partial agonist and/or antagonist activity against tryptaminergic, dopaminergic and alpha adrenergic receptors depending upon their site, and it is a highly active uterine stimulant. It causes constriction of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The pain of a migraine attack is believed to be due to greatly increased amplitude of pulsations in the cranial arteries, especially the meningeal branches of the external carotid artery. Cafergot-PB Suppositories (Ergotamine Tartrate) reduces extracranial blood flow, causes a decline in the amplitude of pulsation in the cranial arteries, and decreases hyperperfusion of the territory of the basilar artery. It does not reduce cerebral hemispheric blood flow.

Pentobarbital:

• Caution
• Description
• Actions
• Indications
• Warning
• Precautions
• Dosage and administration
• How supplied
• Cafergot-PB Suppositories (Pentobarbital) reviews

PRODUCT INFORMATION

CIII

FOR DOGS ONLY

CAUTION

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION

A non-sterile solution containing Cafergot-PB Suppositories (Pentobarbital) sodium and phenytoin sodium as the active ingredients. Rhodamine B, a bluish-red fluorescent dye, is included in the formulation to help distinguish it from parenteral drugs intended for therapeutic use. Although the solution is not sterile, benzyl alcohol, a bacteriostat, is included to retard the growth of microorganisms.

Each mL contains: active ingredients: 390 mg Cafergot-PB Suppositories (Pentobarbital) sodium (barbituric acid derivative), 50 mg phenytoin sodium; inactive ingredients: 10% ethyl alcohol, 18% propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol (preservative), water for injection q.s. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH.

ACTIONS

Cafergot-PB Suppositories (pentobarbital sodium and phenytoin sodium) contains two active ingredients which are chemically compatible but pharmacologically different. Each ingredient acts in such a manner so as to cause humane, painless, and rapid euthanasia. Euthanasia is due to cerebral death in conjunction with respiratory arrest and circulatory collapse. Cerebral death occurs prior to cessation of cardiac activity.

When administered intravenously, Cafergot-PB Suppositories (Pentobarbital) sodium produces rapid anesthetic action. There is a smooth and rapid onset of unconsciousness. At the lethal dose, there is depression of vital medullary respiratory and vasomotor centers.

When administered intravenously, phenytoin sodium produces toxic signs of cardiovascular collapse and/or central nervous system depression. Hypotension occurs when the drug is administered rapidly.

Pharmacodynamic Activity

The sequence of events leading to humane, painless, and rapid euthanasia following intravenous injection of Cafergot-PB Suppositories (Pentobarbital) is similar to that following intravenous injection of Cafergot-PB Suppositories (Pentobarbital) sodium, or other barbituric acid derivatives. Within seconds, unconsciousness is induced with simultaneous collapse of the dog. This stage rapidly progresses to deep anesthesia with concomitant reduction in the blood pressure. A few seconds later, breathing stops, due to depression of the medullary respiratory center; encephalographic activity becomes isoelectric, indicating cerebral death; and then cardiac activity ceases.

Phenytoin sodium exerts its effect during the deep anesthesia stage caused by the Cafergot-PB Suppositories (Pentobarbital) sodium. This ingredient, due to its cardiotoxic properties, hastens the stoppage of electrical activity in the heart.

INDICATIONS

For use in dogs for humane, painless, and rapid euthanasia.

WARNING

For canine euthanasia only. Must not be used for therapeutic purposes. Do not use in animals intended for food.

CAUTION

Caution should be exercised to avoid contact of the drug with open wounds or accidental self-inflicted injections. Keep out of reach of children. If eye contact, flush with water and seek medical advice/attention.

PRECAUTIONS

Euthanasia may sometimes be delayed in dogs with severe cardiac or circulatory deficiencies. This may be explained by the impaired movement of the drug to its site of action. An occasional dog may elicit reflex responses manifested by motor movement; however, an unconscious animal does not experience pain, because the cerebral cortex is not functioning.

When restraint may cause the dog pain, injury, or anxiety, or danger to the person making the injection, prior use of tranquilizing or immobilizing drugs may be necessary.

DOSAGE AND ADMINISTRATION

Dosage

Dogs, 1 mL for each 10 pounds of body weight.

Administration

Intravenous injection is preferred. Intracardiac injection may be made when intravenous injection is impractical, as in a very small dog, or in a comatose dog with impaired vascular functions. Good injection skill is necessary for intracardiac injection.

The calculated dose should be given in a single bolus injection.

For intravenous injection, a needle of sufficient gauge to insure intravenous placement of the entire dose should be used.

HOW SUPPLIED

Cafergot-PB Suppositories is available in 100 mL multiple dose vials.

STORAGE

Store between 15° and 30°C (59° and 86°F).

Manufactured for Virbac AH, Inc., P.O. Box 162059, Fort Worth, TX 76161

For Technical Service contact (800) 338-3659.

© 2003 Virbac AH, Inc. Cafergot-PB Suppositories (Pentobarbital) is a registered trademark of Virbac AH, Inc.

ANADA #200-071, Approved by FDA

02234