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DRUGS & SUPPLEMENTS
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Provas
How long you have been taking the medicine? |
Provas uses
Pharmacological action
Provas is an antihypertensive drug. This medication is a specific antagonist of angiotensin II. It has a selective antagonistic effect on AT1-receptors, which are responsible for implementing the effects of angiotensin II.
Due to the blockade of AT1-receptors the plasma concentrations of angiotensin II increased, which may stimulate the unblocked AT2-receptors. This medicine has no agonistic activity against AT1-receptor. The affinity of Provas for AT1-receptors in about 20 000 times higher than that of AT2-receptors.
Provas does not inhibit ACE. This drug has no interaction and does not block other hormone receptors or ion channels important for regulation of the cardiovascular system.
This medication has no effect on total cholesterol, triglycerides, glucose and uric acid in blood plasma.
A start of antihypertensive action of Provas after its oral administration in a single dose occurs within 2 h after administration, the maximum effect is achieved within 4-6 h.
Pharmacokinetics
After oral administration Provas is rapidly absorbed from the gastrointestinal tract, the extent of absorption is characterized by individual differences. The absolute bioavailability is average 23%.
In course of treatment with this medication there were not noted changes of pharmacokinetic parameters.
When administered with food Provas AUC decreased by 48%, with approximately 8 hours after administration of Provas in plasma concentrations of the same in patients taking it with food and fasting. AUC decrease is not accompanied by clinically significant reduction in therapeutic effect.
When you receive Provas 1 time / day the accumulation is expressed only slightly. The concentration of Provas in the blood plasma of women and men were equal. The binding with plasma proteins, primarily to albumin is 94-97%.
The plasma clearance of Provas is about 2 L / h. This medication is excreted in the feces 70% and in urine 30%, largely unchanged.
When biliary cirrhosis or biliary obstruction AUC of Provas is increased approximately 2-fold.
Why is Provas prescribed?
A treatment of hypertension. A treatment of chronic heart failure in patients receiving conventional therapy with diuretics, digitalis preparations, as well as ACE inhibitors or beta-blockers.
Dosage and administration
Provas is taken orally in dose 80 mg daily 1 time / day or 40 mg 2 times / day. In the absence of adequate effect the daily dose may be gradually increased. The maximum daily dose is 320 mg in 2 divided doses.
Provas side effects, adverse reactions
Cardiovascular system: hypotension, postural dizziness, postural hypotension.
CNS: dizziness, headache.
Digestive system: diarrhea, nausea, increased bilirubin levels.
Urinary system: rarely - renal failure, increased creatinine and BUN.
Metabolic: hyperkalemia.
Hematopoietic system: neutropenia, a decrease in hemoglobin and hematocrit.
Allergic reactions: rarely - angioedema, rash, pruritus, serum sickness, vasculitis.
Other: fatigue, weakness, cough, sore throat, increased risk of viral infections.
Provas contraindications
Pregnancy, hypersensitivity to Provas.
Using during pregnancy and breastfeeding
Provas is contraindicated during pregnancy. It is not known whether Provas is allocated to breast milk in humans. Use during lactation is not recommended.
Experimental studies have shown that this medication is excreted in breast milk of rats.
Category of the fetus by FDA - D.
Special instructions
When hyponatremia and / or reduction of the BCC, as well as during treatment with high doses of diuretics, Provas, in rare cases can cause pronounced hypotension.
Before starting treatment it should be the correction of violations of water-salt metabolism.
In patients with renovascular hypertension, which developed secondary to renal artery stenosis, in the period of treatment should regularly monitor the level of urea and creatinine in serum. There is no data on the safety of patients with CC than 10 ml / min.
With great caution use in patients with impaired patency of the biliary tract.
Due to inhibition of the RAAS in patients predisposed to changes in renal function.
With use of ACE inhibitors and angiotensin receptor antagonists in patients with chronic heart failure severity of the observed oliguria and / or increase azotemia, rarely developed acute renal failure with risk of death.
Safety and efficacy of Provas in children has not been established.
If use Provas it is recommended a caution when driving and management mechanisms.
Provas drug interactions
When this drug applied simultaneously with:
- diuretics in high doses it may developed hypotension.
- potassium-sparing diuretics, heparin, dietary supplements or salt substitutes containing potassium may develop hyperkalemia.
- indomethacin may decrease the antihypertensive action of Provas.
- lithium carbonate, described the case of lithium toxicity.
Provas in case of emergency / overdose
Symptoms: hypotension, tachycardia or bradycardia.
Treatment: symptomatic therapy, dialysis is not effective.
Provas pharmaceutical active ingredients containing related brand and generic drugs:
Provas available forms, composition, doses:
Provas destination | category:
Provas Anatomical Therapeutic Chemical codes:
Provas pharmaceutical companies:
References
- Dailymed."DIOVAN (VALSARTAN) TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."AMLODIPINE BESYLATE; VALSARTAN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "valsartan". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Provas?Depending on the reaction of the Provas after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Provas not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Provas addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Provas, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Provas consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Provas useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
Four visitors reported side effects
Did you get side effects while taking the Provas drug, or were there no side effects?According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Provas medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
| Visitors | % | ||
|---|---|---|---|
| It has side effects | 3 | 75.0% | |
| No side effects | 1 | 25.0% | |
Visitor reported price estimates
No survey data has been collected yetThree visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Provas drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Provas is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 2 | 66.7% | |
| Twice in a day | 1 | 33.3% | |
Five visitors reported doses
What is the dose of Provas drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 6-10mg | 2 | 40.0% | |
| 1-5mg | 1 | 20.0% | |
| 501mg-1g | 1 | 20.0% | |
| 51-100mg | 1 | 20.0% | |
One visitor reported time for results
What is the time duration Provas drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 days to notice the result from using Provas drug. The time needed to show improvement in health condition after using the medicine Provas need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 3 days | 1 | 100.0% | |
One visitor reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Provas drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| Before food | 1 | 100.0% | |
Five visitors reported age
| Visitors | % | ||
|---|---|---|---|
| 6-15 | 2 | 40.0% | |
| 1-5 | 2 | 40.0% | |
| 30-45 | 1 | 20.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology