|
|||
|
DRUGS & SUPPLEMENTS
|
Pentobarbital
How long you have been taking the medicine? |
Pentobarbital uses
PRODUCT INFORMATION
CIII
FOR DOGS ONLY
CAUTION
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
DESCRIPTION
A non-sterile solution containing Pentobarbital sodium and phenytoin sodium as the active ingredients. Rhodamine B, a bluish-red fluorescent dye, is included in the formulation to help distinguish it from parenteral drugs intended for therapeutic use. Although the solution is not sterile, benzyl alcohol, a bacteriostat, is included to retard the growth of microorganisms.
Each mL contains: active ingredients: 390 mg Pentobarbital sodium (barbituric acid derivative), 50 mg phenytoin sodium; inactive ingredients: 10% ethyl alcohol, 18% propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol (preservative), water for injection q.s. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH.
ACTIONS
Pentobarbital contains two active ingredients which are chemically compatible but pharmacologically different. Each ingredient acts in such a manner so as to cause humane, painless, and rapid euthanasia. Euthanasia is due to cerebral death in conjunction with respiratory arrest and circulatory collapse. Cerebral death occurs prior to cessation of cardiac activity.
When administered intravenously, Pentobarbital sodium produces rapid anesthetic action. There is a smooth and rapid onset of unconsciousness. At the lethal dose, there is depression of vital medullary respiratory and vasomotor centers.
When administered intravenously, phenytoin sodium produces toxic signs of cardiovascular collapse and/or central nervous system depression. Hypotension occurs when the drug is administered rapidly.
Pharmacodynamic Activity
The sequence of events leading to humane, painless, and rapid euthanasia following intravenous injection of Pentobarbital is similar to that following intravenous injection of Pentobarbital sodium, or other barbituric acid derivatives. Within seconds, unconsciousness is induced with simultaneous collapse of the dog. This stage rapidly progresses to deep anesthesia with concomitant reduction in the blood pressure. A few seconds later, breathing stops, due to depression of the medullary respiratory center; encephalographic activity becomes isoelectric, indicating cerebral death; and then cardiac activity ceases.
Phenytoin sodium exerts its effect during the deep anesthesia stage caused by the Pentobarbital sodium. This ingredient, due to its cardiotoxic properties, hastens the stoppage of electrical activity in the heart.
INDICATIONS
For use in dogs for humane, painless, and rapid euthanasia.
WARNING
For canine euthanasia only. Must not be used for therapeutic purposes. Do not use in animals intended for food.
| ENVIRONMENTAL HAZARD: This product is toxic to wildlife. Birds and mammals feeding on treated animals may be killed. Euthanized animals must be properly disposed of by deep burial, incineration, or other method in compliance with state and local laws, to prevent consumption of carcass material by scavenging wildlife. |
CAUTION
Caution should be exercised to avoid contact of the drug with open wounds or accidental self-inflicted injections. Keep out of reach of children. If eye contact, flush with water and seek medical advice/attention.
PRECAUTIONS
Euthanasia may sometimes be delayed in dogs with severe cardiac or circulatory deficiencies. This may be explained by the impaired movement of the drug to its site of action. An occasional dog may elicit reflex responses manifested by motor movement; however, an unconscious animal does not experience pain, because the cerebral cortex is not functioning.
When restraint may cause the dog pain, injury, or anxiety, or danger to the person making the injection, prior use of tranquilizing or immobilizing drugs may be necessary.
DOSAGE AND ADMINISTRATION
Dosage
Dogs, 1 mL for each 10 pounds of body weight.
Administration
Intravenous injection is preferred. Intracardiac injection may be made when intravenous injection is impractical, as in a very small dog, or in a comatose dog with impaired vascular functions. Good injection skill is necessary for intracardiac injection.
The calculated dose should be given in a single bolus injection.
For intravenous injection, a needle of sufficient gauge to insure intravenous placement of the entire dose should be used.
HOW SUPPLIED
Pentobarbital is available in 100 mL multiple dose vials.
STORAGE
Store between 15° and 30°C (59° and 86°F).
Manufactured for Virbac AH, Inc., P.O. Box 162059, Fort Worth, TX 76161
For Technical Service contact (800) 338-3659.
© 2003 Virbac AH, Inc. Pentobarbital is a registered trademark of Virbac AH, Inc.
ANADA #200-071, Approved by FDA
02234
Pentobarbital pharmaceutical active ingredients containing related brand and generic drugs:
Pentobarbital available forms, composition, doses:
| Price | |
| Capsules; Oral; Pentobarbital Sodium 100 mg | |
| Capsules; Oral; Pentobarbital Sodium 50 mg | |
| Injectable; Injection; Pentobarbital Sodium 50 mg / ml | |
| Nembutal sodium 50 mg/ml via | 20.65 USD |
| Pentobarbital sodium powder | 27.0 USD |
| Tablets; Oral; Pentobarbital Sodium 100 mg |
Pentobarbital destination | category:
Pentobarbital Anatomical Therapeutic Chemical codes:
Pentobarbital pharmaceutical companies:
References
- Dailymed."PENTASOL (PENTOBARBITAL SODIUM) POWDER [VIRBAC AH, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."PENTOBARBITAL SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "pentobarbital". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Pentobarbital?Depending on the reaction of the Pentobarbital after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Pentobarbital not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Pentobarbital addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Pentobarbital, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Pentobarbital consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetOne visitor reported frequency of use
How often in a day do you take the medicine?Are you taking the Pentobarbital drug as prescribed by the doctor?
Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Pentobarbital is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| 3 times in a day | 1 | 100.0% | |
Two visitors reported doses
What is the dose of Pentobarbital drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 11-50mg | 1 | 50.0% | |
| 51-100mg | 1 | 50.0% | |
Visitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology