Nitrosun

When are you taking this medicine?
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Nitrosun uses


Pharmacological action

Nitrosun is an hypnotic drug from benzodiazepines group. This medication has a marked sedative effect, anxiolytic, sedative, anticonvulsant and central muscle relaxant effect. The mechanism of action is associated with increased inhibitory effect of GABA in the CNS by increasing the sensitivity of the GABA-receptor mediator as a result of stimulation of benzodiazepine receptors. Nitrosun increases the depth and duration of sleep. Sleep usually occurs in 20-40 minutes after ingestion and lasts for 6-8 hours. Moderately inhibits the phase of the quick sleep.

Pharmacokinetics

The plasma protein binding is more than 80%. Vd is 1.9 L / kg. T1/2 is an average of 26 hours. Nitrosun is excreted mainly as metabolites.

Why is Nitrosun prescribed?

Sleep disorders of various origins, somnambulism, premedication before surgery, encephalopathy, accompanied by epileptic seizures.

Dosage and administration

The daily dose for adults is ranged from 2.5 mg to 25 mg; the multiplicity of usind is set individually. The daily dose for children is 0.6-1 mg.

Nitrosun side effects, adverse reactions

CNS and peripheral nervous system: fatigue, impaired concentration, psychomotor retardation reactions, muscle weakness; rarely - headaches, ataxia, confusion, amnesia, depression, blurred vision, in predisposed patients may be worsening of suicidal thoughts, hallucinations.

Cardiovascular system: rarely - hypotension.

Digestive system: rarely - dry mouth, nausea, diarrhea.

Respiratory system: patients with obstructive pulmonary disease possible respiratory depression.

Reproductive system: changes in libido.

Allergic reactions: seldom - a skin rash, itching.

Nitrosun contraindications

Acute respiratory failure, drug or alcohol dependence, myasthenia gravis, temporal lobe epilepsy, angle-closure glaucoma, acute intoxication with drugs, providing a depressing effect on the central nervous system or alcohol abuse, hypersensitivity to benzodiazepines.

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Using during pregnancy and breastfeeding

There was not conducted adequate and well-controlled studies safety of Nitrosun during pregnancy and lactation. Nitrosun is contraindicated especially in I and III trimester of pregnancy.

If necessary Nitrosun using during lactation breastfeeding should be discontinued.

Special instructions

Nitrosun should be used with caution in severe respiratory failure, obstructive pulmonary disease, ataxia, sleep apnea, marked hepatic dysfunction.

With prolonged use may develop drug dependence.

During the period of treatment avoid taking alcohol.

During the period of treatment patients should refrain from activities potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Nitrosun drug interactions

Simultaneous administration of Nitrosun with:

  • drugs providing a depressing effect on the CNS, with ethanol, ethanol containing drugs is enhanced inhibitory effect on the CNS.
  • anticonvulsant drugs may mutual enhancement of toxic effects.
  • Nitrosun potentiates the action of antihypertensive drugs.
  • estrogen containing oral contraceptives increases the concentration in blood plasma Nitrosun.
  • probenecid may interfere with the glucuronide binding of Nitrosun that leads to an increase in its concentration in plasma and by enhancing the therapeutic effect may develop excessive sedation.
  • rifampicin increased excretion from the body of Nitrosun
  • cimetidine increases the concentration of nitrazepama in blood plasma, which may be accompanied by increased sedation. It may be slow the hepatic metabolism of Nitrosun. This can lead to a lengthening of T1/2 of Nitrosun and for long-term use - an increase of its concentration in blood plasma.

    Nitrosun in case of emergency / overdose

    Symptoms: CNS depression of varying severity - lethargy, weakness, severe drowsiness, deep sleep, confusion, decreased response to painful stimuli; in more severe cases - ataxia, areflexia, hypotension, respiratory depression and cardiac activity, coma.

    Treatment: induction of vomiting or gastric lavage, activated charcoal technique, monitoring vital signs, symptomatic therapy, intravenous fluids, if necessary - mechanical ventilation. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital).

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    Nitrosun pharmaceutical active ingredients containing related brand and generic drugs:


    Nitrosun available forms, composition, doses:


    Nitrosun destination | category:


    Nitrosun Anatomical Therapeutic Chemical codes:


    Nitrosun pharmaceutical companies:


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    References

    1. "nitrazepam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    2. "nitrazepam". http://www.drugbank.ca/drugs/DB0159... (accessed August 28, 2018).
    3. "9CLV70W7HS: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Nitrosun?

    Depending on the reaction of the Nitrosun after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Nitrosun not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Nitrosun addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Nitrosun, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Nitrosun consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    Visitor reported price estimates

    No survey data has been collected yet

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Nitrosun drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Nitrosun is mentioned below.
    Visitors%
    Once in a day1
    100.0%

    Five visitors reported doses

    What is the dose of Nitrosun drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    6-10mg5
    100.0%

    One visitor reported time for results

    What is the time duration Nitrosun drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 month to notice the result from using Nitrosun drug. The time needed to show improvement in health condition after using the medicine Nitrosun need not be same for all the users. It varies based on other factors.
    Visitors%
    1 month1
    100.0%

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Nitrosun drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    After food1
    100.0%

    Visitor reported age

    No survey data has been collected yet

    Visitor reviews


    There are no reviews yet. Be the first to write one!


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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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