DRUGS & SUPPLEMENTS

Terican

Name: Terican drug & pharmaceuticals. Terican available forms, doses, prices
Creator: sdrugs.com
Published: 2021-11-11T10:10:10+00:00

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Terican uses

Terican reviews

Terican is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Terican prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death.

Indication: For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Terican is currently under investigation for the treatment of metastatic or recurrent cervical cancer.

Terican is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Terican is a semisynthetic derivative of camptothecin. Camptothecins interact specifically with topoisomerase I, an enzyme in the cell nucleus that regulates DNA topology and facilitates nuclear processes such as DNA replication, recombination, and repair. During these processes, topoisomerase I relieves torsional strain in DNA by inducing reversible single-strand breaks, allowing single DNA strands to pass through the break. The 3'-DNA terminus of the broken DNA strands bind covalently with the topoisomerase enzyme to form a catalytic intermediate called a cleavable complex. After the DNA is sufficiently relaxed and the strand passage reaction is complete, DNA topoisomerase reattaches the broken DNA strands to form the chemically unaltered topoisomers that allow transcription to proceed. Terican and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Terican is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Terican or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Terican in humans is not known. Terican is cell cycle phase-specific (S-phase).

Terican pharmaceutical active ingredients containing related brand and generic drugs:

Irinotecan Hydrochloride

Terican available forms, composition, doses:

Injectable; Injection; Irinotecan Hydrochloride 20 mg / ml

Terican destination | category:

Human:
Antineoplastic agents
Cytotoxic chemotherapy

Terican Anatomical Therapeutic Chemical codes:

L01XX19 - Irinotecan

Terican pharmaceutical companies:

Landsteiner Scientific

References

Dailymed."IRINOTECAN HYDROCHLORIDE INJECTION, SOLUTION [HOSPIRA, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
"irinotecan". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
"irinotecan". http://www.drugbank.ca/drugs/DB0076... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Terican?

Depending on the reaction of the Terican after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Terican not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Terican addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

sdrugs.com conducted a study on Terican, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Terican consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.