Nepatic

Rating: 5 - 1 review(s)
What are the side effects you encounter while taking this medicine?
advertisement

Nepatic uses


Pharmacological action

Nepatic is an antiepileptic drug. Chemical structure is similar to GABA fulfilling the function of the inhibitory neurotransmitter in the CNS. It is believed that the mechanism of action of Nepatic is different from other anticonvulsants acting through GABA synapses. In in vitro studies showed that Nepatic is characterized by the presence of a new peptide binding sites in the brain tissues of rats, including the hippocampus and cerebral cortex, which may be relevant to the anticonvulsant activity of Nepatic and its derivatives. Nepatic in clinically relevant concentrations is not associated with other conventional drugs and neurotransmitter receptors in the brain.

The final mechanism of action of Nepatic is not defined.

Pharmacokinetics

Nepatic is absorbed from the gastrointestinal tract. After oral administration of Nepatic Cmax in plasma achieved within 2-3 hours. The absolute bioavailability of approximately 60%. Taking of this medication in conjunction with food (including a high-fat) does not affect the pharmacokinetics of Nepatic.

Nepatic is not bound to plasma proteins and has Vd 57.7 l.

Nepatic is excreted only by the kidneys. Signs of biotransformation of Nepatic in the human body were not found.

Nepatic is removed from plasma by hemodialysis.

The concentrations of Nepatic in the plasma of children were similar to those of adults.

Why is Nepatic prescribed?

Treatment of neuropathic pain in adults over the age of 18 years; monotherapy of partial seizures with secondary generalization and without its fot children and adults older than 12 years; as an adjunct in the treatment of partial seizures with secondary generalization and without its for adults and children aged 3 years and older.

Dosage and administration

Dosing regimen of Nepatic is individual, depending on the indications and treatment regimens.

Nepatic side effects, adverse reactions

CNS and peripheral nervous system: amnesia, ataxia, confusion, impaired coordination, depression, dizziness, dysarthria, nervous hyperexcitability, nystagmus, drowsiness, impaired thinking, tremor, muscle cramps, amblyopia, diplopia, hyperkinesia, strengthening, weakening or absence of reflexes, paresthesia, anxiety, hostility, impaired gait.

Digestive system: change in staining of teeth, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests.

Hemopoietic system: leucopenia, decrease the number of leukocytes, thrombocytopenic purpura.

Respiratory system: rhinitis, pharyngitis, cough, pneumonia.

Musculoskeletal system: myalgia, arthralgia, bone fractures.

Cardiovascular: hypertension, manifestations of vasodilation.

Urinary system: urinary tract infections, urinary incontinence.

Allergic reactions: erythema multiforme, Stevens-Johnson syndrome.

Dermatological reactions: maceration of the skin, acne, itching, rash.

Other: back pain, fatigue, peripheral edema, impotence, fatigue, malaise, swelling of the face, increase in body weight, accidental injury, asthenia, flu-like syndrome, fluctuations in blood glucose in children - a viral infection, otitis media.

advertisement

Nepatic contraindications

Hypersensitivity to Nepatic.

Using during pregnancy and breastfeeding

Adequate and well-controlled studies on the safety of Nepatic during pregnancy and lactation in humans has not been conducted. If necessary use Nepatic during pregnancy and lactation patients should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or infant.

Nepatic is excreted in breast milk. When this drug used in the lactation period, the character of the action of Nepatic on the infant is not defined.

Category effects on the fetus by FDA - C.

Special instructions

Abrupt discontinuation of therapy by anticonvulsant drugs in patients with partial seizures may provoke a convulsive status. If necessary to reduce the dose of Nepatic, to cancel or replace it with an alternative means it should be phased over a minimum of 1 week.

Nepatic is not an effective drug for treatment of absence seizures.

For patients with impaired renal function and patients in hemodialysis it requires correction of dosing regimen. Elderly patients may require correction of the dosing regimen of Nepatic due to the fact that such patients may decrease renal clearance.

The efficacy and safety of neuropathic pain treatment in patients under age 18 is not defined.

During the period of treatment it is necessary to avoid taking alcohol.

Prior to determining individual response to treatment the patient should refrain from potentially dangerous activities coupled with the need to focus and improve the speed of psychomotor reactions.

Nepatic drug interactions

Simultaneous administration of Nepatic with:

  • antacids reduces the absorption of Nepatic from the gastrointestinal tract.
  • felbamate may increase its T1/2.
  • described a case of increasing the concentration of phenytoin in blood plasma.

    Nepatic in case of emergency / overdose

    There was reported an acute overdose while taking 49 g of Nepatic. Symptoms: double vision, slurred speech, drowsiness, lethargy, diarrhea.

    Treatment: maintenance therapy, hemodialysis.

    advertisement

    Nepatic pharmaceutical active ingredients containing related brand and generic drugs:


    Nepatic available forms, composition, doses:


    Nepatic destination | category:


    Nepatic Anatomical Therapeutic Chemical codes:


    Nepatic pharmaceutical companies:


    advertisement

    References

    1. Dailymed."GABAPENTIN TABLET, FILM COATED [LAKE ERIE MEDICAL & SURGICAL S6758UPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."GABAPENTIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. "gabapentin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Nepatic?

    Depending on the reaction of the Nepatic after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Nepatic not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Nepatic addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

    advertisement

    Review

    sdrugs.com conducted a study on Nepatic, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Nepatic consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    One visitor reported side effects

    Did you get side effects while taking the Nepatic drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Nepatic medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    No side effects1
    100.0%

    Visitor reported price estimates

    No survey data has been collected yet

    Visitor reported frequency of use

    No survey data has been collected yet

    One visitor reported doses

    What is the dose of Nepatic drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    201-500mg1
    100.0%

    One visitor reported time for results

    What is the time duration Nepatic drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using Nepatic drug. The time needed to show improvement in health condition after using the medicine Nepatic need not be same for all the users. It varies based on other factors.
    Visitors%
    > 3 month1
    100.0%

    Visitor reported administration

    No survey data has been collected yet

    Visitor reported age

    No survey data has been collected yet

    Visitor reviews


    There are no reviews yet. Be the first to write one!


    Your name: 
    Email: 
    Spam protection:  < Type 16 here

    The information was verified by Dr. Rachana Salvi, MD Pharmacology

    © 2002 - 2024 "sdrugs.com". All Rights Reserved