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DRUGS & SUPPLEMENTS
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Carbetapentane Citrate:
Rx Only
Description: POLY HIST CB is an alcohol-free, sugar-free, purple liquid for oral administration
having a grape odor and flavor.
Each Teaspoon (5 mL) Contains:
PD Cough (Carbetapentane Citrate) CITRATE... 20 mg
GUAIFENESIN...75 mg
POLY HIST CB Liquid also contains: FD and C Blue #1, FD and C Red #40, Grape Flavor, Maltitol,
Propylene Glycol, Sodium Saccharin, Sorbitol, Purified Water.
Pharmacology: PD Cough (Carbetapentane Citrate) citrate is a centrally acting non-narcotic antitussive.
Guaifenesin is an expectorant. Its action increases the output of respiratory tract fluid by reducing
adhesiveness and surface tension. Sinus and bronchial drainage is improved and dry, nonproductive
coughs become more productive and less frequent.
the common cold, influenza, sinusitis, and bronchitis.
hypersensitivity to any of the components. It is also contraindicated in patients on MAO inhibitor therapy.
or tends to recur, or is accompanied by fever, rash, or persistent headache, patient reevaluation
should be considered.
may therefore interfere with the interpretation of this test for the diagnosis of carcinoid syndrome. It may
also falsely elevate the VMA test for catechols. Administration of this drug should be discontinued 48 hours
prior to the collection of urine specimens for such tests.
of POLY HIST CB have a potential for carcinogenesis, mutagenesis, or impairment of fertility.
It is not known whether it can cause fetal harm when administered to a pregnant woman or can affect
reproduction capacity. This product should not be administered to pregnant women.
mild and infrequent. Nausea and vomiting are the most common side effects. Dizziness,
headache, and rash (including urticaria) have been reported rarely.
is unlikely to produce serious toxic effects. In laboratory animals no toxicity resulted when
guaifenesin was administered by stomach tube in doses up to 5 grams/kg.
TREATMENT: Treatment of the signs and symptoms of overdosage is symptomatic and
supportive. The patient should be induced to vomit, even if emesis has occurred spontaneously.
Pharmacologic vomiting by the administration of ipecac syrup is a preferred method, however,
vomiting should not be induced in patients with impaired consciousness. Precautions against
aspiration must be taken, especially in infants and children. Following emesis, any drug
remaining in the stomach may be absorbed by activated charcoal administered as a slurry with water.
Adults: 1-2 teaspoonfuls every 4-6 hours or as directed by a physician.
Children 6-12 years of age: 1 teaspoonful every 4-6 hours or as directed by a physician.
Children 2-6 years of age: 1/2 teaspoonful every 4-6 hours or as directed by a physician.
Children under 2 years of age: As directed by a physician.
KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN.
IN CASE OF ACCIDENTAL OVERDOSAGE, CONTACT A POISON CONTROL
CENTER AND SEEK PROFESSIONAL ASSISTANCE IMMEDIATELY.
Tamper evident by foil seal under cap. Do not use if foil seal is broken or missing.
Store at controlled room temperature, 59o-86oF (15o-30oC).
DISPENSE IN TIGHT, LIGHT RESISTANT CONTAINERS WITH CHILD RESISTANT CLOSURES
AS DEFINED IN THE USP/NF.
Manufactured for:
Poly Pharmaceuticals
Mobile, AL 36619
Rx Only
Rev. 11/09
NDC 50991-781-16
Poly Hist CB
Grape Flavor
Sugar Freee Alcohol Free
Antitussive/Expectorant
Each 5 mL (1 teaspoonful) contains:
PD Cough (Carbetapentane Citrate) Citrate... 20 mg
Guaifenesin... 75 mg
Distributed by:
Poly Pharmaceuticals
Mobile, AL 36619
Rx Only
16 fl oz (473 mL)
Side Panel:
USUAL
Dosage: Adults 12 years and older: 1-2 teaspoonfuls every 4-6 hours.
Children 6-12 years of age: 1 teaspoonful every 4-6 hours. Children 2-6 years of age:
1/2 teaspoonful every 4-6 hours. Children under 2 years of age: As directed by a physician.
See package insert for complete prescribing information.
KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN.
IN CASE OF ACCIDENTAL OVERDOSAGE, CONTACT A POISON CONTROL
CENTER AND SEEK PROFESSIONAL ASSISTANCE IMMEDIATELY.
Tamper evident by foil seal under cap. Do not use if foil seal is broken or missing.
This bottle is not to be dispensed to consumer.
STORAGE: Store at controlled room temperature, 59o-86oF (15o-30oC).
Mfg. for: Poly Pharmaceuticals, Mobile, AL 36619
Mfg. by: Great Southern Laboratories. Houston, TX 77099
Rev. 11/09
Poly Hist CB Packaging Poly Hist CB Packaging
Dextromethorphan Hydrobromide:
PD Cough is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. PD Cough (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. PD Cough (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. PD Cough (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. PD Cough (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. PD Cough (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.
After oral administration PD Cough (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. Cmax of PD Cough (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.
Dry cough of different etiology.
For adults and children over 12 years PD Cough prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.
Drowsiness, nausea, dizziness.
Bronchial asthma, bronchitis, simultaneous reception of mucolytic.
During pregnancy and lactation (breastfeeding) PD Cough (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.
With carefully administered PD Cough (Dextromethorphan Hydrobromide) with impaired liver function.
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with PD Cough (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) PD Cough (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.
Treatment: mechanical ventilation, symptomatic agents.
Guaifenesin:
Indication: Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
PD Cough (Guaifenesin) is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, PD Cough (Guaifenesin) increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
Phenylpropanolamine Hydrochloride:
Indication: For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
PD Cough (Phenylpropanolamine Hydrochloride) (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. PD Cough (Phenylpropanolamine Hydrochloride) is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing PD Cough (Phenylpropanolamine Hydrochloride), due to an increased risk of hemorrhagic stroke in women who used PD Cough (Phenylpropanolamine Hydrochloride).
Depending on the reaction of the PD Cough after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider PD Cough not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is PD Cough addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology