Zycin

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Zycin uses


Pharmacological action

Zycin is a macrolide antibiotic of azalides group. Zycin inhibits RNA-dependent protein synthesis of sensitive microorganisms.

It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. ; gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Pharmacokinetics

Zycin rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of Zycin. Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the Zycin is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.

Why is Zycin prescribed?

Infectious-inflammatory diseases caused by microorganisms susceptible to Zycin, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease.

Dosage and administration

Dosage of Zycin is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Zycin side effects, adverse reactions

Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.

Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Dermatological reactions: rarely - photosensitization.

CNS: dizziness, headache, rarely - drowsiness, weakness.

Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.

Cardiovascular system: rarely - chest pain.

Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.

Other: rarely - hyperglycemia, arthralgia.

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Contraindications

Hypersensitivity to Zycin and other macrolide antibiotics.

Using during pregnancy and breastfeeding

Zycin crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary to use Zycin in the lactation period should solve the issue of termination of breastfeeding.

Special instructions

Zycin not recommended for use in patients with compromised liver function.

Zycin uses with careful with impaired renal function.

This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.

Zycin drug interactions

Simultaneous administration of Zycin with these drugs and medications may has followed effects:

  • ergot alkaloids: can not been exclude the risk of ergotism;
  • warfarin: there was described amplification effect of warfarin;
  • digoxin or digitoxin: may be significantly increase the concentration of cardiac glycosides in plasma and risk of glycoside intoxication;
  • disopyramide: described a case of ventricular fibrillation;
  • lovastatin: there was describes some cases of rhabdomyolysis;
  • Zycin with rifabutin increases risk of neutropenia and leukopenia;
  • cyclosporine: disturbed metabolism of cyclosporine which increases the risk of adverse and toxic reactions caused by cyclosporine

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    Zycin pharmaceutical active ingredients containing related brand and generic drugs:


    Zycin available forms, composition, doses:


    Zycin destination | category:


    Zycin Anatomical Therapeutic Chemical codes:


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    References

    1. Dailymed."AZITHROMYCIN TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."AZITHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. "azithromycin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Zycin?

    Depending on the reaction of the Zycin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zycin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Zycin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Zycin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zycin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Zycin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
    Visitors%
    Expensive1
    100.0%

    Four visitors reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Zycin drug as prescribed by the doctor?

    Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Zycin is mentioned below.
    Visitors%
    Twice in a day2
    50.0%
    Once in a day2
    50.0%

    Visitor reported doses

    No survey data has been collected yet

    Two visitors reported time for results

    What is the time duration Zycin drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 5 days to notice the result from using Zycin drug. The time needed to show improvement in health condition after using the medicine Zycin need not be same for all the users. It varies based on other factors.
    Visitors%
    5 days1
    50.0%
    3 days1
    50.0%

    Visitor reported administration

    No survey data has been collected yet

    Three visitors reported age

    Visitors%
    > 602
    66.7%
    30-451
    33.3%

    Visitor reviews


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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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