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DRUGS & SUPPLEMENTS
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Sine-Off Night Time Relief Sinus Cold and Flu Medicine
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Sine-Off Night Time Relief Sinus Cold and Flu Medicine uses
Sine-Off Night Time Relief Sinus Cold and Flu Medicine consists of Acetaminophen, Diphenhydramine Hydrochloride, Pseudoephedrine Hydrochloride.Acetaminophen:
Pharmacological action
Sine-Off Night Time Relief Sinus Cold and Flu Medicine is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Sine-Off Night Time Relief Sinus Cold and Flu Medicine, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) on the fetus in humans.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen).
Special Instructions
Sine-Off Night Time Relief Sinus Cold and Flu Medicine is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen).
When Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) with ethinylestradiol increases absorption of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Sine-Off Night Time Relief Sinus Cold and Flu Medicine in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Diphenhydramine Hydrochloride:
Pharmacological action
Sine-Off Night Time Relief Sinus Cold and Flu Medicine Xepa-Soul Pattinson is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.
When Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson administered orally Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.
When applied externally it has antiallergic effect.
Pharmacokinetics
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is achieved after 20-40 min (in the greatest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).
Why is Sine-Off Night Time Relief Sinus Cold and Flu Medicine Xepa-Soul Pattinson prescribed?
Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.
Dosage and administration
Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral dose of Sine-Off Night Time Relief Sinus Cold and Flu Medicine Xepa-Soul Pattinson for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson side effects, adverse reactions
Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.
Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine Xepa-Soul Pattinson contraindications
Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride).
Using during pregnancy and breastfeeding
During pregnancy and lactation, Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.
Special instructions
With careful use Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) during pregnancy and lactation.
During the period of treatment with Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson should not be exposed to solar radiation should be avoided alcohol.
Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.
Precautionary measures
Sine-Off Night Time Relief Sinus Cold and Flu Medicine Xepa-Soul Pattinson is not recommended for SC injection. Since Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history (including asthma), increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson drug interactions
When Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.
With simultaneous use of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson and MAO inhibitors increase the anticholinergic activity of Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Diphenhydramine Hydrochloride).
The antagonistic interaction observed with a joint appointment with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.
Sine-Off Night Time Relief Sinus Cold and Flu Medicine Xepa-Soul Pattinson in case of emergency / overdose
Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.
Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.
Pseudoephedrine Hydrochloride:
Active ingredients (in each caplet)...Purpose
Guaifenesin 400 mg...Expectorant
Sine-Off Night Time Relief Sinus Cold and Flu Medicine (Pseudoephedrine Hydrochloride) hydrochloride 60 mg...Nasal decongestant
Uses
For temporarily relief of nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis), and to help loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Uses
- temporarily relieves nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis).
- helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Warnings
Do not exceed recommended dosage.
Do not use if you are taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for two weeks after stopping the MAOI. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Do not take this product for persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema, or where cough is accompanied by excessive phlegm (mucus) unless directed by a doctor.
A persistent cough may be a sign of a serious condition. If cough persists for more than 1 week, tends to recur, or is accompanied by fever, rash, or persistent headache, consult a doctor.
Ask a doctor before use if you have
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- difficulty in urinating due to an enlarged prostate gland
Stop use and ask a doctor if
- you get nervous, dizzy, or sleepless
- symptoms do not improve within 7 days or are accompanied by fever
If pregnant or breast-feeding, ask a health professional before use.
Keep this and all drugs out of reach of children. In case of overdose, get medical help or contact a poison control center immediately.
Directions
- adults and children 12 years and older, 1 caplet every 4 to 6 hours, not more than 4 caplets in 24 hours
- children 6 to under 12 years, ½ caplet every 4 to 6 hours, not more than 2 caplets in 24 hours
- children under 6 years, consult a physician
Inactive ingredients
croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, sodium starch glycolate, and starch
Questions?
1-800-324-1880, 7:30am - 4:00pm Central, Mon.-Fri., or visit us at www.bfascher.com
Sine-Off Night Time Relief Sinus Cold and Flu Medicine
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References
- Dailymed."SUDOGEST (PSEUDOEPHEDRINE HYDROCHLORIDE) TABLET, FILM COATED [MAJOR PHARMACEUTICALS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."VICKS ZZZQUIL LIQUID AND LIQUICAPS COMBO (DIPHENHYDRAMINE HYDROCHLORIDE) KIT [THE PROCTER & GAMBLE MANUFACTURING COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."FEVERALL INFANTS (ACETAMINOPHEN) SUPPOSITORY [ACTAVIS MID ATLANTIC LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Sine-Off Night Time Relief Sinus Cold and Flu Medicine?Depending on the reaction of the Sine-Off Night Time Relief Sinus Cold and Flu Medicine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Sine-Off Night Time Relief Sinus Cold and Flu Medicine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Sine-Off Night Time Relief Sinus Cold and Flu Medicine addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology