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DRUGS & SUPPLEMENTS
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Contac Night Cold and Flu
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Contac Night Cold and Flu uses
Contac Night Cold and Flu consists of Acetaminophen, Dextromethorphan Hydrobromide, Diphenhydramine Hydrochloride, Pseudoephedrine Hydrochloride.Acetaminophen:
Pharmacological action
Contac Night Cold and Flu is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Contac Night Cold and Flu (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Contac Night Cold and Flu dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Contac Night Cold and Flu side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Contac Night Cold and Flu, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Contac Night Cold and Flu (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Contac Night Cold and Flu (Acetaminophen) on the fetus in humans.
Contac Night Cold and Flu (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Contac Night Cold and Flu (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Contac Night Cold and Flu (Acetaminophen).
Special Instructions
Contac Night Cold and Flu is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Contac Night Cold and Flu (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Contac Night Cold and Flu (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Contac Night Cold and Flu (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Contac Night Cold and Flu (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Contac Night Cold and Flu (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Contac Night Cold and Flu (Acetaminophen).
When Contac Night Cold and Flu (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Contac Night Cold and Flu (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Contac Night Cold and Flu (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Contac Night Cold and Flu (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Contac Night Cold and Flu (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Contac Night Cold and Flu (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Contac Night Cold and Flu (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Contac Night Cold and Flu (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Contac Night Cold and Flu (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Contac Night Cold and Flu (Acetaminophen) with ethinylestradiol increases absorption of Contac Night Cold and Flu (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Contac Night Cold and Flu in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Dextromethorphan Hydrobromide:
Pharmacological action
Contac Night Cold and Flu is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Contac Night Cold and Flu (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Contac Night Cold and Flu (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Contac Night Cold and Flu (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Contac Night Cold and Flu (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Contac Night Cold and Flu (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.
Pharmacokinetics
After oral administration Contac Night Cold and Flu (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. Cmax of Contac Night Cold and Flu (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.
Why is Contac Night Cold and Flu prescribed?
Dry cough of different etiology.
Dosage and administration
For adults and children over 12 years Contac Night Cold and Flu prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.
Contac Night Cold and Flu (Dextromethorphan Hydrobromide) side effects, adverse reactions
Drowsiness, nausea, dizziness.
Contac Night Cold and Flu contraindications
Bronchial asthma, bronchitis, simultaneous reception of mucolytic.
Using during pregnancy and breastfeeding
During pregnancy and lactation (breastfeeding) Contac Night Cold and Flu (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.
Special instructions
With carefully administered Contac Night Cold and Flu (Dextromethorphan Hydrobromide) with impaired liver function.
Contac Night Cold and Flu drug interactions
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Contac Night Cold and Flu (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Contac Night Cold and Flu (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Contac Night Cold and Flu in case of emergency / overdose
Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.
Treatment: mechanical ventilation, symptomatic agents.
Diphenhydramine Hydrochloride:
Pharmacological action
Contac Night Cold and Flu Xepa-Soul Pattinson is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.
When Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson administered orally Contac Night Cold and Flu (Diphenhydramine Hydrochloride) has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.
When applied externally it has antiallergic effect.
Pharmacokinetics
Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is achieved after 20-40 min (in the greatest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).
Why is Contac Night Cold and Flu Xepa-Soul Pattinson prescribed?
Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.
Dosage and administration
Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral dose of Contac Night Cold and Flu Xepa-Soul Pattinson for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.
Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson side effects, adverse reactions
Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.
Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.
Contac Night Cold and Flu Xepa-Soul Pattinson contraindications
Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to Contac Night Cold and Flu (Diphenhydramine Hydrochloride).
Using during pregnancy and breastfeeding
During pregnancy and lactation, Contac Night Cold and Flu (Diphenhydramine Hydrochloride) used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.
Special instructions
With careful use Contac Night Cold and Flu (Diphenhydramine Hydrochloride) during pregnancy and lactation.
During the period of treatment with Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson should not be exposed to solar radiation should be avoided alcohol.
Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.
Precautionary measures
Contac Night Cold and Flu Xepa-Soul Pattinson is not recommended for SC injection. Since Contac Night Cold and Flu (Diphenhydramine Hydrochloride) has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history (including asthma), increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with Contac Night Cold and Flu (Diphenhydramine Hydrochloride) should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.
Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson drug interactions
When Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.
With simultaneous use of Contac Night Cold and Flu (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson and MAO inhibitors increase the anticholinergic activity of Contac Night Cold and Flu (Diphenhydramine Hydrochloride).
The antagonistic interaction observed with a joint appointment with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.
Contac Night Cold and Flu Xepa-Soul Pattinson in case of emergency / overdose
Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.
Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.
Pseudoephedrine Hydrochloride:
Active ingredients (in each caplet)...Purpose
Guaifenesin 400 mg...Expectorant
Contac Night Cold and Flu (Pseudoephedrine Hydrochloride) hydrochloride 60 mg...Nasal decongestant
Uses
For temporarily relief of nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis), and to help loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Uses
- temporarily relieves nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis).
- helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Warnings
Do not exceed recommended dosage.
Do not use if you are taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for two weeks after stopping the MAOI. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Do not take this product for persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema, or where cough is accompanied by excessive phlegm (mucus) unless directed by a doctor.
A persistent cough may be a sign of a serious condition. If cough persists for more than 1 week, tends to recur, or is accompanied by fever, rash, or persistent headache, consult a doctor.
Ask a doctor before use if you have
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- difficulty in urinating due to an enlarged prostate gland
Stop use and ask a doctor if
- you get nervous, dizzy, or sleepless
- symptoms do not improve within 7 days or are accompanied by fever
If pregnant or breast-feeding, ask a health professional before use.
Keep this and all drugs out of reach of children. In case of overdose, get medical help or contact a poison control center immediately.
Directions
- adults and children 12 years and older, 1 caplet every 4 to 6 hours, not more than 4 caplets in 24 hours
- children 6 to under 12 years, ½ caplet every 4 to 6 hours, not more than 2 caplets in 24 hours
- children under 6 years, consult a physician
Inactive ingredients
croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, sodium starch glycolate, and starch
Questions?
1-800-324-1880, 7:30am - 4:00pm Central, Mon.-Fri., or visit us at www.bfascher.com
Contac Night Cold and Flu
Contac Night Cold and Flu pharmaceutical active ingredients containing related brand and generic drugs:
Contac Night Cold and Flu available forms, composition, doses:
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References
- Dailymed."SUDOGEST (PSEUDOEPHEDRINE HYDROCHLORIDE) TABLET, FILM COATED [MAJOR PHARMACEUTICALS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."VICKS ZZZQUIL LIQUID AND LIQUICAPS COMBO (DIPHENHYDRAMINE HYDROCHLORIDE) KIT [THE PROCTER & GAMBLE MANUFACTURING COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."ADULT WAL TUSSIN COUGH LONG ACTING (DEXTROMETHORPHAN HYDROBROMIDE) SOLUTION [WALGREEN COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Contac Night Cold and Flu?Depending on the reaction of the Contac Night Cold and Flu after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Contac Night Cold and Flu not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Contac Night Cold and Flu addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology