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DRUGS & SUPPLEMENTS
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Active ingredient: Trimeprazine Tartrate
How often in a day do you take medicine? How many times? |
Trimeprazine Tartrate uses
- Indications and usage
- Warning
- Precautions and side effects
- Dosage and administration
- How supplied
- References
INDICATIONS AND USAGE
1. Antipruritic
Trimeprazine Tartrate is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis. It often relieves pruritus which does not respond to other therapy. With any pruritus treatment, the cause should be determined and corrected; otherwise, signs are likely to recur following discontinuance of therapy.
2. Antitussive
Trimeprazine Tartrate has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its antipruritic action, Trimeprazine Tartrate is recommended for the treatment of "kennel cough" or tracheobronchitis, bronchitis including all allergic bronchitis, and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiencies would not be expected to respond to Trimeprazine Tartrate therapy.) As with any antitussive treatment, the etiology of the cough should be determined and eliminated if possible. Otherwise, symptoms are likely to recur following discontinuance of therapy.
Note: Trimeprazine Tartrate may be administered to animals suffering from acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.
WARNING
Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia, and anasarca. If a vasoconstrictor is needed, norepinephrine should be used in lieu of epinephrine. Phenothiazine derivatives may reverse the usual elevating action of epinephrine causing a further lowering of blood pressure.
PRECAUTIONS AND SIDE EFFECTS
All the precautions applicable to cortisone and to phenothiazine derivatives apply also to Trimeprazine Tartrate. Possible side effects attributable to corticosteroids include sodium retention and potassium loss, negative nitrogen balance, suppressed adrenal cortical function, delayed wound healing, osteoporosis, elevated levels of SGPT and SAP, and vomiting and diarrhea (occasionally bloody). Cushings syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. Possible increased susceptibility to bacterial invasion and/or the exacerbation of preexisting bacterial infection may occur in patients receiving corticosteroids. As noted above, however, this problem can be avoided by concomitant use of appropriate anti-infective agents. Possible side effects attributable to phenothiazine derivatives include sedation; protruding nictitating membrane; blood dyscrasias; intensification and prolongation of the action of analgesics, sedatives and general anesthetics; and potentiation of organophosphate toxicity and the activity of procaine hydrochloride.
It should be remembered that the premonitory signs of cortisone overdosage, such as sodium retention and edema, may not occur with prednisolone. Therefore, the veterinarians must be alert to detect less obvious side effects, such as blood dyscrasias, polydipsia, and polyuria.
The appearance and severity of side effects are dose related and are minimal at the recommended dosage level. If troublesome side effects are encountered, the dosage of Trimeprazine Tartrate should be reduced and discontinued unless the severity of the condition being treated makes its relief paramount.
Prolonged treatment with Trimeprazine Tartrate must be withdrawn gradually. Use of corticosteroids, depending on dose, duration, and specific steroid, may result in inhibition of endogenous steroid production following drug withdrawal. In patients presently receiving or recently withdrawn from systemic steroid treatments, therapy with a rapidly acting corticosteroid should be considered in unusually stressful situations.
DOSAGE AND ADMINISTRATION
The same dosage schedule may be followed for both antipruritic and antitussive therapy.
| Weight of Dog | Initial Dosage |
|---|---|
| Up to 10 lb | 1/2 tablet, twice daily |
| 11–20 lb | 1 tablet, twice daily |
| 21–40 lb | 2 tablets, twice daily |
| Over 40 lb | 3 tablets, twice daily |
After 4 days, reduce dosage to 1/2 of the initial dose or to an amount just sufficient to maintain remission of symptoms. Individual animal response will vary and dosage should be adjusted until proper response is obtained.
Store in a Dry, Cool Place at Temperatures Not Above 25°C (77°F)
HOW SUPPLIED
100- and 1000-tablet bottles.
REFERENCES
- Knowles JO, Knowles RP: Preliminary reports on an effective antipruritic agent. Vet Med 55(8):67–68, 1960.
- Candlin FT: An agent to aid in control of pruritus. Vet Med 56(5):207–208, 1961.
- Yoxall AT, Hird JRF: Pharmacological Basis of Small Animal Medicine. Blackwell Scientific Publications, London, pp. 99–102, 1979.
- Booth N, McDonald LE: Veterinary Pharmacology and Therapeutics, 5th ed. Iowa State University Press, Ames, pp. 564–570, 1982.
- Davis L: Handbook of Small Animal Therapeutics. Churchill Livingstone, New York, pp. 140–142; 459–461; 468–469, 1985.
- Scott D: Systemic glucocorticoid therapy. Current Veterinary Therapy, Kirk WV Saunders, ed., Philadelphia, pp. 988–994, 1980.
- Lecture: "Rational Steroid Therapy" Duncan C. Ferguson, VMD, PhD, Department of Pharmacology, Cornell University.
- Kemppianen RJ, Lorenz MD, Thompson FN: Adrenocortical suppression in the dog given a single intramuscular dose of prednisolone or triamcinolone acetonide. Am J Vet Res 42(2):204–206, 1982.
- Rogers WA, Ruebner BH: A retrospective study of probable glucocorticoid induced hepatopathy in dogs. JAVMA 1977;170(6): 603-605.
NADA #12-437, Approved by FDA
Distributed by:
Zoetis Inc.
Kalamazoo, MI 49007
13846200
Revised: January 2013
Eye
Trimeprazine Tartrate ®
(trimeprazine with prednisolone)
Tablets
Antipruritic–Antitussive–
Anti-inflammatory
For use in dogs
Each tablet contains Trimeprazine Tartrate tartrate
USP 10-[3-(Dimethylamino)-2-methylpropyl]-
phenothiazine tartrate (2:1) equivalent to
Trimeprazine Tartrate, 5 mg, and prednisolone, 2 mg.
Caution: Federal law restricts this drug to use
by or on the order of a licensed veterinarian.
100 tablets
NADA #12-437, Approved by FDA
zoetis
Trimeprazine Tartrate ®
(trimeprazine with prednisolone)
Tablets
Antipruritic–Antitussive–Anti-inflammatory
For use in dogs
Each tablet contains Trimeprazine Tartrate tartrate USP 10-[3-(Di-
methylamino)-2-methylpropyl]-phenothiazine tartrate (2:1)
equivalent to Trimeprazine Tartrate, 5 mg, and prednisolone, 2 mg.
Caution: Federal law restricts this drug to use by or on
the order of a licensed veterinarian.
1000 tablets
NADA #12-437, Approved by FDA
zoetis
Trimeprazine Tartrate available forms, composition, doses:
Indications and Usages:
ATC codes:
ICD-10 codes:
Trimeprazine Tartrate destination | category:
Drugs with same active ingredients (Pharmaceutical companies):
References
- Dailymed."TRIMEPRAZINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "trimeprazine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "trimeprazine". http://www.drugbank.ca/drugs/DB0124... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Trimeprazine Tartrate?Depending on the reaction of the Trimeprazine Tartrate after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Trimeprazine Tartrate not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Trimeprazine Tartrate addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Trimeprazine Tartrate, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Trimeprazine Tartrate consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
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No survey data has been collected yetOne visitor reported time for results
What is the time duration Trimeprazine Tartrate drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using Trimeprazine Tartrate drug. The time needed to show improvement in health condition after using the medicine Trimeprazine Tartrate need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| > 3 month | 1 | 100.0% | |
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The information was verified by Dr. Rachana Salvi, MD Pharmacology