Zicam Multi-Symptom Cold and Flu Daytime

Acetaminophen:

• Pharmacological action
• Why is Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) prescribed?
• Zicam Multi-Symptom Cold and Flu Daytime dosage and administration
• Zicam Multi-Symptom Cold and Flu Daytime side effects, adverse reactions
• Contraindications
• Using during pregnancy and breastfeeding
• Special Instructions
• Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) Drug Interactions
• Zicam Multi-Symptom Cold and Flu Daytime in case of emergency / overdose
• Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) reviews

Pharmacological action

Zicam Multi-Symptom Cold and Flu Daytime is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) prescribed?

Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.

Zicam Multi-Symptom Cold and Flu Daytime dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Zicam Multi-Symptom Cold and Flu Daytime side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Zicam Multi-Symptom Cold and Flu Daytime, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).

Using during pregnancy and breastfeeding

Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) on the fetus in humans.

Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen).

Special Instructions

Zicam Multi-Symptom Cold and Flu Daytime is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).

Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen).

With the simultaneous use of oral contraceptives accelerated excretion of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen).

When Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen). A case of severe toxic liver injury.

Described cases of toxic effects of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) due to increasing its metabolism in the liver.

At simultaneous application of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) with ethinylestradiol increases absorption of Zicam Multi-Symptom Cold and Flu Daytime (Acetaminophen) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Zicam Multi-Symptom Cold and Flu Daytime in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

Dextromethorphan Hydrobromide:

• Pharmacological action
• Pharmacokinetics
• Why is Zicam Multi-Symptom Cold and Flu Daytime prescribed?
• Dosage and administration
• Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) side effects, adverse reactions
• Zicam Multi-Symptom Cold and Flu Daytime contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Zicam Multi-Symptom Cold and Flu Daytime drug interactions
• Zicam Multi-Symptom Cold and Flu Daytime in case of emergency / overdose
• Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) reviews

Pharmacological action

Zicam Multi-Symptom Cold and Flu Daytime is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. C_max of Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Zicam Multi-Symptom Cold and Flu Daytime prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Zicam Multi-Symptom Cold and Flu Daytime prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) side effects, adverse reactions

Drowsiness, nausea, dizziness.

Zicam Multi-Symptom Cold and Flu Daytime contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) with impaired liver function.

Zicam Multi-Symptom Cold and Flu Daytime drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Zicam Multi-Symptom Cold and Flu Daytime (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Zicam Multi-Symptom Cold and Flu Daytime in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Guaifenesin:

• Zicam Multi-Symptom Cold and Flu Daytime (Guaifenesin) reviews

Indication: Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

Zicam Multi-Symptom Cold and Flu Daytime (Guaifenesin) is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, Zicam Multi-Symptom Cold and Flu Daytime (Guaifenesin) increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.