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DRUGS & SUPPLEMENTS
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What is the dose of the medication you are taking? |
Indication: For the treatment of mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure (CHF), to improve survival following myocardial infarction (MI) in individuals who are hemodynamically stable and demonstrate symptoms of left ventricular systolic dysfunction or signs of CHF within a few days following acute MI, and to slow progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
Trandolapril is the ethyl ester prodrug of a nonsulfhydryl ACE inhibitor, trandolaprilat. Trandolapril is deesterified in the liver to the diacid metabolite, trandolaprilat, which is approximately eight times more active as an inhibitor of ACE than its parent compound. ACE is a peptidyl dipeptidase that is part of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure via a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may further sustain the effects of trandolaprilat by causing increased vasodilation and decreased blood pressure. The blood pressure lowering effect of trandolaprilat is due to a decrease in peripheral vascular resistance, which is not accompanied by significant changes in urinary excretion of chloride or potassium or water or sodium retention.
Price | |
Capsules; Oral; Trandolapril 0.5 mg | |
Capsules; Oral; Trandolapril 2 mg | |
Capsules; Oral; Trandolapril 4 mg | |
Mavik 0.5 mg Capsule | 0.42 USD |
Mavik 1 mg Capsule | 0.72 USD |
Mavik 1 mg tablet | 1.47 USD |
Mavik 2 mg Capsule | 0.83 USD |
Mavik 2 mg tablet | 1.61 USD |
Mavik 4 mg Capsule | 1.03 USD |
Mavik 4 mg tablet | 1.61 USD |
Tablets; Oral; Trandolapril 1 mg | |
Tablets; Oral; Trandolapril 2 mg | |
Tablets; Oral; Trandolapril 3 mg | |
Tablets; Oral; Trandolapril 4 mg | |
Tarka 1-240 mg Controlled Release Tabs | 3.46 USD |
Tarka 1-240 mg tablet sa | 3.33 USD |
Tarka 2-180 mg Controlled Release Tabs | 3.29 USD |
Tarka 2-180 mg tablet sa | 3.33 USD |
Tarka 2-240 mg Controlled Release Tabs | 3.33 USD |
Tarka 2-240 mg tablet sa | 3.33 USD |
Tarka 4-240 mg Controlled Release Tabs | 3.4 USD |
Tarka 4-240 mg tablet sa | 3.33 USD |
Trandolapril 1 mg tablet | 1.24 USD |
Trandolapril 2 mg tablet | 1.23 USD |
Trandolapril 4 mg tablet | 1.23 USD |
Depending on the reaction of the Trandolapril after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Trandolapril not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Trandolapril addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology