Stalene

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Stalene uses


Pharmacological action

Stalene is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.

Pharmacokinetics

Stalene is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Stalene is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T1/2 is 30 h. Stalene is excreted by the kidneys, 80% of the administered dose in an unmodified form.

Why is Stalene prescribed?

Cryptococcosis, systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.

Dosage and administration

Dosing regimen of Stalene is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of Stalene should be reduced.

Stalene side effects, adverse reactions

Digestive system: nausea, abdominal pain, diarrhea, flatulence.

CNS: headache, dizziness.

Allergic reactions: skin rash, anaphylactic reactions.

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Stalene contraindications

Pregnancy, children up to age 1 year, increased sensitivity to Stalene and triazole compounds.

Using during pregnancy and breastfeeding

Stalene is contraindicated during pregnancy and lactation.

If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.

Special instructions

Stalene should be used with caution in patients with severe impaired liver or kidney diseases.

Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.

Stalene drug interactions

Simultaneous administration of Stalene with:

  • coumarin anticoagulants marked increase in prothrombin time.
  • rifampicin observed shortening of the half-life of Stalene. Stalene Sorres Pharma increases the half-life of oral hypoglycemic agents - sulfonylureas in healthy people. Simultaneous use of Stalene and oral hypoglycemic agents in diabetic patients is allowed, however, the physician should bear in mind the possibility of hypoglycemia.

    Stalene in case of emergency / overdose

    Symptoms: nausea, vomiting, diarrhea and seizures in severe cases.

    Treatment: gastric lavage, forced diuresis, hemodialysis (three-hour dialysis reduces the plasma concentrations of approximately 50%), symptomatic therapy.

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    Stalene pharmaceutical active ingredients containing related brand and generic drugs:


    Stalene available forms, composition, doses:


    Stalene destination | category:


    Stalene Anatomical Therapeutic Chemical codes:


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    References

    1. Dailymed."FLUCONAZOLE TABLET [BRYANT RANCH PREPACK]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."FLUCONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. "fluconazole". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Stalene?

    Depending on the reaction of the Stalene after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Stalene not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Stalene addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Stalene, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Stalene consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    Visitor reported price estimates

    No survey data has been collected yet

    Visitor reported frequency of use

    No survey data has been collected yet

    Two visitors reported doses

    What is the dose of Stalene drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 101-200mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    101-200mg2
    100.0%

    Visitor reported time for results

    No survey data has been collected yet

    Visitor reported administration

    No survey data has been collected yet

    Two visitors reported age

    Visitors%
    < 11
    50.0%
    30-451
    50.0%

    Visitor reviews


    There are no reviews yet. Be the first to write one!


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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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