Lopram

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Lopram uses


Pharmacological action

Lopram is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Lopram lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.

Pharmacokinetics

After oral administration Cmax of Lopram in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Lopram are linear. Css in the plasma is established within 1-2 weeks of therapy.

Binding to plasma proteins is less than 80%.

In blood plasma Lopram is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.

T1/2 is 1.5 days.

Lopram is excreted by the kidneys and the bowel.

Why is Lopram prescribed?

Depression of various etiologies, panic disorder, obsessive-compulsive disorder.

Dosage and administration

Lopram is taken oral 1 time / day.

For adults depending on the evidence the initial dose of Lopram is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.

Lopram side effects, adverse reactions

Digestive system: frequently - dry mouth, nausea.

CNS: frequently - drowsiness, tremor, and in rare cases - seizures.

Cardiovascular system: possible slight decrease in heart rate.

Other: often - increased sweating.

Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.

Lopram contraindications

Hypersensitivity to Lopram; simultaneous taking MAO inhibitors.

Using during pregnancy and breastfeeding

Safety of Lopram during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.

In experimental studies there was revealed no teratogenic effects and any effect of Lopram on reproduction and prenatal development of the fetus.

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Special instructions

In patients with liver failure Lopram should be used in minimal doses.

At weak and moderate renal insufficiency it does not require correction of dosing regimen of Lopram Meliapharm, the information on the application in severe renal failure is absent.

During the treatment period with Lopram it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Lopram may cause a more pronounced bradycardia.

The efficacy and safety of Lopram in children has not been established.

Lopram should not be used concurrently with MAO inhibitors.

Patients should be prescribed with care for Lopram in highest dose and high doses of cimetidine.

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Lopram drug interactions

Simultaneous administration of Lopram with:

  • MAO inhibitors may develop a hypertensive crisis ;
  • cimetidine may moderate increase in Css of Lopram in plasmaThe inhibitory effect on CYP2D6 isoenzyme is expressed very poorly, so the interaction with drugs that affect the metabolism of this enzyme is minimal. But we can not exclude the decrease in the concentration of Lopram in plasma by increasing its metabolism by carbamazepine induction of liver enzymes in their simultaneous application.

    The effects of sumatriptan and other serotonergic medications can be amplified by Lopram in their simultaneous application.

    Lopram in case of emergency / overdose

    Symptoms: dizziness, sweating, nausea, vomiting, tremor, somnolence, sinus tachycardia. In more rare cases - amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, ECG changes.

    Treatment: gastric lavage and use of activated carbon. Maintaining an airway to ensure adequate ventilation and oxygenation. It is recommended careful observation and monitoring of vital functions. Due to the large volume of distribution of Lopram is unlikely efficiency such measures as forced diuresis, dialysis, hemoperfusion and exchange transfusion. There is no specific antidote.

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    Lopram pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Lopram available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Lopram destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Lopram Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Lopram pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."CITALOPRAM TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "citalopram". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "citalopram". http://www.drugbank.ca/drugs/DB0021... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Lopram?

    Depending on the reaction of the Lopram after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Lopram not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Lopram addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Lopram, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Lopram consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    One visitor reported side effects

    Did you get side effects while taking the Lopram drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Lopram medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    No side effects1
    100.0%

    Visitor reported price estimates

    No survey data has been collected yet

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Lopram drug as prescribed by the doctor?

    Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Lopram is mentioned below.
    Visitors%
    3 times in a day1
    100.0%

    One visitor reported doses

    What is the dose of Lopram drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    1-5mg1
    100.0%

    One visitor reported time for results

    What is the time duration Lopram drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 2 weeks to notice the result from using Lopram drug. The time needed to show improvement in health condition after using the medicine Lopram need not be same for all the users. It varies based on other factors.
    Visitors%
    2 weeks1
    100.0%

    Visitor reported administration

    No survey data has been collected yet

    One visitor reported age

    Visitors%
    > 601
    100.0%

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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