Fluoxetine

Fluoxetine uses

• Pharmacological action
• Pharmacokinetics
• Why is Fluoxetine prescribed?
• Dosage and administration
• Fluoxetine side effects, adverse reactions
• Fluoxetine contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Fluoxetine drug interactions
• Fluoxetine in case of emergency / overdose
• Fluoxetine reviews

Pharmacological action

Fluoxetine is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Fluoxetine is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Fluoxetine apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Fluoxetine does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.

Pharmacokinetics

Fluoxetine absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. C_max in plasma is reached after 6-8 hours. C_ss in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Fluoxetine easily penetrates through the BBB.

Fluoxetine metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.

T_1/2 of Fluoxetine is 2-3 days, norfluoxetine - 7-9 days.

Why is Fluoxetine prescribed?

Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosage and administration

The initial dose of Fluoxetine is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.

The maximum oral daily dose for adults is 80 mg.

Fluoxetine side effects, adverse reactions

CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.

Digestive system: diarrhea, nausea.

Metabolism: increased sweating, hypoglycemia, hyponatremia.

Reproductive system: decreased libido.

Allergic reactions: skin rash, itching.

Other: pain in joints and muscles, shortness of breath, increased body temperature.

Fluoxetine contraindications

Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Fluoxetine.

Using during pregnancy and breastfeeding

Fluoxetine is contraindicated during pregnancy and lactation.

Special instructions

Fluoxetine should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.

Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Fluoxetine increases the risk of epileptic seizures.

With the simultaneous application of Fluoxetine and electroconvulsive therapy may develop prolonged seizures.

Fluoxetine can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Fluoxetine before therapy MAO inhibitors should not be less than 5 weeks.

Elderly patients need correction of dosing regimen.

Safety of Fluoxetine in children has not been established.

During the period of treatment it needed to avoid use alcohol.

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

Fluoxetine drug interactions

Simultaneous administration of Fluoxetine with: