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DRUGS & SUPPLEMENTS
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Domer
What are the side effects you encounter while taking this medicine? |
Domer uses
Pharmacological action
Domer is an inhibitor of H+ K+ ATPase. This medication inhibits the activity of H+-K+-ATPase in gastric parietal cells and thus blocks the final stage of hydrochloric acid secretion. This leads to a reduction in basal and stimulated secretion, regardless of the nature of the stimulus. Due to the reduction of acid secretion Domer reduces or normalizes the effects of acid in the esophagus in patients with reflux esophagitis.
Domer has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori when Domer used with antibiotics allows to quickly arrest the symptoms, to take a high degree of healing of damaged mucosa and persistent long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.
Pharmacokinetics
After oral administration Domer is rapidly absorbed from the gastrointestinal tract. This drug penetrates the parietal cells of gastric mucosa. Plasma protein binding is about 95%. Domer is biotransformed in the liver. Excreted by the kidneys - 72-80%, in the faeces - about 20%. T1/2 is 0.5-1 h. In patients with chronic liver diseases T1/2 increases up to 3 hours.
Why is Domer prescribed?
Gastric ulcer and duodenal ulcer in acute phase (including associated with Helicobacter pylori), reflux esophagitis, Zollinger-Ellison syndrome, erosive and ulcerative lesions of gastric and duodenal ulcers associated with taking NSAIDs.
Dosage and administration
The dosing regimen of Domer is individual. When this medication is administered orally of the single dose is 20-40 mg. The daily dose is 20-80 mg, the frequency of use is 1-2 times / day. The duration of treatment is 2-8 weeks.
Domer side effects, adverse reactions
Digestive system: rarely - nausea, diarrhea, constipation, abdominal pain, flatulence.
CNS: rarely - headache, dizziness, weakness.
Hemopoietic system: in some cases - anemia, eosinopenia, neutropenia, thrombocytopenia.
Urinary system: in some cases - hematuria, proteinuria.
Musculoskeletal system: in some cases - arthralgia, muscle weakness, myalgia.
Allergic reactions: rarely - skin rash.
Domer contraindications
Chronic liver disease, hypersensitivity to Domer.
Using during pregnancy and breastfeeding
In the absence of clinical experience with Domer it is not recommended to use this drug during pregnancy. If necessary to use during Domer lactation it should been solve the issue of termination of breastfeeding.
Category effects on the fetus by FDA - C.
Special instructions
Before the treatment with Domer it is necessary to exclude the possibility of a malignant process because Domer treatment can mask symptoms and delay the correct diagnosis.
Therapy with Domer may affects results of laboratory studies of liver and gastrin concentrations in blood plasma.
Due to lack of experience in clinical application of Domer this medicine is not recommended for children.
Domer drug interactions
This medication alters the bioavailability of any drug, absorption depends on pH (ketoconazole, iron salts, etc.). Domer slows down the elimination of drugs metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin, etc.).
Domer enhances the action of coumarin and diphenine, does not change - NSAIDs. This drug increases (relative) the concentration of clarithromycin in the blood; may increases the leukopenic and thrombocytopenic effects of depressants hematopoiesis drugs. Substance for intravenous infusion is compatible only with saline and dextrose (using other solvents may decrease the stability of Domer due to changes in pH of infusion medium).
Domer in case of emergency / overdose
Symptoms: dry mouth, nausea, blurred vision, headache, increased sweating, flushing, tachycardia, drowsiness, confusion.
Treatment: symptomatic, dialysis is ineffective.
Domer pharmaceutical active ingredients containing related brand and generic drugs:
Domer available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.