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DRUGS & SUPPLEMENTS
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Apo-Zopiclone
When are you taking this medicine? |
Apo-Zopiclone uses
Pharmacological action
Apo-Zopiclone is a sleeping drug from group of cyclopyrrolone derivatives. This drug is "non benzodiazepine" agonist of benzodiazepine receptors. Apo-Zopiclone also has sedative, anxiolytic, muscle-relaxing center, anticonvulsant and amnesic properties. Like a derivative of benzodiazepine Apo-Zopiclone enhances GABA-ergic processes in the brain, interacting with the benzodiazepine receptors, as a result of the increased sensitivity of GABA-receptors to the neurotransmitter. However, Apo-Zopiclone apparently interacts with other parts of the benzodiazepine receptor than benzodiazepines.
Apo-Zopiclone reduced sleep time, reduces the number of nighttime awakenings, increases total sleep time. This medication almost has no effect on sleep structure, does not reduce significantly the amount of REM sleep. Consequences of the phenomenon of waking up are missing or expressed little. Readmission Apo-Zopiclone are not accompanied by cumulation.
Pharmacokinetics
Apo-Zopiclone rapidly and completely absorbed from the gastrointestinal tract. Cmax achieved within 1-3 hours. Apo-Zopiclone easily passes through gistogematicheskie barriers including the BBB and it is distributed in organs and tissues including brain. T1/2 is 5.5-6 hours, not accumulates.
Why is Apo-Zopiclone prescribed?
Sleep disturbance, transient, situational or chronic insomnia; sleep disturbances in mental disorders, bronchial asthma with nocturnal seizures (in combination with single dose daily dose of theophylline).
Dosage and administration
The average therapeutic dose of Apo-Zopiclone is 7.5 mg orally at night, in cases of severe insomnia the dose can be increased up to 15 mg. In elderly patients, as well as abnormal liver function is used 3.75 mg.
Apo-Zopiclone side effects, adverse reactions
Digestive system: a feeling of bitter or metallic taste in the mouth, dry mouth, nausea, and vomiting.
CNS: dizziness, headache, drowsiness, confusion, anterograde amnesia, hallucinations, nightmares.
Dermatologic reactions: skin rash.
Apo-Zopiclone contraindications
Severe respiratory failure, pregnancy, lactation, children and teens under 15 years old, hypersensitivity to Apo-Zopiclone.
Using during pregnancy and breastfeeding
Apo-Zopiclone is contraindicated during pregnancy (especially in I and III trimester) and lactation (breastfeeding). If a woman uses Apo-Zopiclone in III trimester of pregnancy there are possible violations of the nervous system in the newborn, the emergence of withdrawal syndrome. If the woman is prescribed by a doctor took Apo-Zopiclone immediately prior to labor and delivery, it needs a constant medical surveillance for the newborn. At the time of treatment it should be stoped breastfeeding (zopiclone penetrates into breast milk).
Special instructions
With caution use in patients with severe liver failure.
Risk of drug dependence is minimal if the duration of Apo-Zopiclone did not exceed 4 weeks. However, the potential danger of Apo-Zopiclone dependence to exist.
During the period of treatment patients should to exclude the use of alcohol.
On the next day after taking the drug it should be cautious to drive and operate machinery.
Apo-Zopiclone drug interactions
Simultaneous administration of Apo-Zopiclone with trimipramine reduces the concentration of trimipramine in plasma and its effect.
Apo-Zopiclone increases the influence of CNS depressants.
Apo-Zopiclone in case of emergency / overdose
Symptoms: CNS depression of varying severity (from drowsiness to loss of consciousness).
Treatment: gastric lavage, taking activated charcoal, if necessary - symptomatic therapy. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital). Hemodialysis is ineffective.
Apo-Zopiclone pharmaceutical active ingredients containing related brand and generic drugs:
Apo-Zopiclone available forms, composition, doses:
Apo-Zopiclone destination | category:
Apo-Zopiclone Anatomical Therapeutic Chemical codes:
Apo-Zopiclone pharmaceutical companies:
References
- "zopiclone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "zopiclone". http://www.drugbank.ca/drugs/DB0119... (accessed August 28, 2018).
- "zopiclone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Apo-Zopiclone?Depending on the reaction of the Apo-Zopiclone after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Apo-Zopiclone not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Apo-Zopiclone addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Apo-Zopiclone, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Apo-Zopiclone consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetVisitor reported frequency of use
No survey data has been collected yetVisitor reported doses
No survey data has been collected yetOne visitor reported time for results
What is the time duration Apo-Zopiclone drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Apo-Zopiclone drug. The time needed to show improvement in health condition after using the medicine Apo-Zopiclone need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 1 day | 1 | 100.0% | |
Visitor reported administration
No survey data has been collected yetTwo visitors reported age
| Visitors | % | ||
|---|---|---|---|
| > 60 | 2 | 100.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology