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DRUGS & SUPPLEMENTS
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Antiflu-Des
How old is patient? |
Antiflu-Des uses
Antiflu-Des consists of Acetaminophen, Amantadine Hydrochloride, Chlorpheniramine Maleate.Acetaminophen:
Pharmacological action
Antiflu-Des is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Antiflu-Des (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Antiflu-Des dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Antiflu-Des side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Antiflu-Des, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Antiflu-Des (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Antiflu-Des (Acetaminophen) on the fetus in humans.
Antiflu-Des (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Antiflu-Des (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Antiflu-Des (Acetaminophen).
Special Instructions
Antiflu-Des is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Antiflu-Des (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Antiflu-Des (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Antiflu-Des (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Antiflu-Des (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Antiflu-Des (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Antiflu-Des (Acetaminophen).
When Antiflu-Des (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Antiflu-Des (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Antiflu-Des (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Antiflu-Des (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Antiflu-Des (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Antiflu-Des (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Antiflu-Des (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Antiflu-Des (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Antiflu-Des (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Antiflu-Des (Acetaminophen) with ethinylestradiol increases absorption of Antiflu-Des (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Antiflu-Des in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Amantadine Hydrochloride:
Pharmacological action
Antiflu-Des is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.
This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. Antiflu-Des (Amantadine Hydrochloride) inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater Antiflu-Des (Amantadine Hydrochloride) influences on stiffness (rigidity and bradykinesia).
This medicine inhibits the penetration of influenza A virus into the cell.
Pharmacokinetics
Antiflu-Des (Amantadine Hydrochloride) after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of Antiflu-Des (Amantadine Hydrochloride) sulfate is 12-13 hours, in contrast to Antiflu-Des (Amantadine Hydrochloride) hydrochloride, which T1/2 is 30 hours.
Why is Antiflu-Des prescribed?
Parkinson's disease, Parkinson's syndrome (rigidity, tremor, hypokinesia).
Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.
Prevention (including in combination with vaccination) and treatment of influenza A.
Dosage and administration
For oral administration the single dose is 100-200 mg.
IV in the form of infusion in 200 mg during 3 hours.
The frequency and duration of Antiflu-Des use depends on the evidence, the patient's response to treatment, the epidemiological situation.
The maximum dose for oral administration is 600 mg / day.
Antiflu-Des (Amantadine Hydrochloride) side effects, adverse reactions
CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.
Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.
Digestive system: rarely - anorexia, nausea, constipation, dry mouth.
Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.
Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities (livedo reticularis).
Antiflu-Des contraindications
Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to Antiflu-Des (Amantadine Hydrochloride).
Using during pregnancy and breastfeeding
The use of Antiflu-Des in pregnancy is possible only under strict indications and under the supervision of a physician.
If necessary to use during lactation it been should decide on the termination of breastfeeding.
Category of the fetus by FDA - C.
Special instructions
Use Antiflu-Des (Amantadine Hydrochloride) with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of Antiflu-Des (Amantadine Hydrochloride) is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.
An information about the effectiveness of Antiflu-Des (Amantadine Hydrochloride) to reduce extrapyramidal disorders during treatment with antipsychotic drugs (Parkinson's drug) are contradictory.
During treatment avoid drinking alcohol.
In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.
Antiflu-Des drug interactions
When this drug applied simultaneously with:
- may increase the side effects of other antiparkinsonian medications.
- thiazide diuretics can not been excluded the possibility of toxic effects of Antiflu-Des (Amantadine Hydrochloride) (ataxia, agitation, hallucinations), probably by reducing its renal clearance.
- quinine, quinidine may decrease the excretion of Antiflu-Des (Amantadine Hydrochloride) in urine.
There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.
Chlorpheniramine Maleate:
Drug Facts
| Active Ingredients (in each 1 mL dropperful) | Purpose |
|---|---|
| Antiflu-Des (Chlorpheniramine Maleate) Maleate 2 mg | Antihistamine |
| Phenylephrine HCl 5 mg | Nasal Decongestant |
Uses
temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies
- runny nose
- sneezing
- itching of the nose or throat
- itchy, watery eyes
- nasal congestion
- reduces swelling of nasal passages
Warnings
Do not exceed recommended dosage.
Do not use this product in a child who is
- now taking a prescription monoamine oxidase inhibitor (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product.
Ask a doctor before use if a child has
- a breathing problem such as chronic bronchitis
- glaucoma
- heart disease
- high blood pressure
- thyroid disease
- diabetes mellitus
Ask a doctor before use if a child is taking sedatives or tranquilizers
When using this product
- excitability may occur, especially in children
- may cause drowsiness
- sedatives and tranquilizers may increase drowsiness effect
Stop use and ask a doctor if
- nervousness, dizziness, or sleeplessness occur
- new symptoms occur
Keep out of reach of children. In case of accidental overdose, seek professional help or contact a Poison Control Center immediately.
Directions
Do not exceed recommended dosage.
| Children 6 to under 12 years of age: | 1 mL (1 dropperful) every 4 hours, not to exceed 6 mL in 24 hours or as directed by a doctor |
| Children 2 to under 6 years of age: | 0.5 mL (1/2 dropperful) every 4 hours, not to exceed 3 mL in 24 hours, or as directed by a doctor |
| Children under 2 years of age: | Consult a doctor |
Other information
Store at 59°-86°F (15°-30°C)
Inactive ingredients
Applesauce Flavor, Citric Acid, FD&C Blue #1, FD&C Yellow #6, Glycerin, Methyl Paraben, Potassium Citrate, Potassium Sorbate, Propyl Paraben, Propylene Glycol, Purified Water, Sucralose
Questions? Comments?
Call 1-800-543-9560
Rev. 05/11
E
NEW
FORMULA
NDC 00485-0096-02
Antiflu-Des (Chlorpheniramine Maleate)
Pediatric Drops
Antihistamine ▪ Nasal Decongestant
Sugar Free ▪ Alcohol Free ▪ Gluten Free
FOR PROFESSIONAL USE ONLY
Each 1 mL for oral administration
contains:
Antiflu-Des (Chlorpheniramine Maleate) Maleate
2 mg
Phenylephrine HCl
5 mg
APPLESAUCE FLAVOR
Tamper evident by foil seal under cap.
Do not use if foil seal is broken or missing.
Manufactured for:
EDWARDS
Pharmaceuticals, Inc.
Ripley, MS 38663
2 fl. oz. (60 mL)
Antiflu-Des pharmaceutical active ingredients containing related brand and generic drugs:
Antiflu-Des available forms, composition, doses:
Antiflu-Des destination | category:
Antiflu-Des Anatomical Therapeutic Chemical codes:
Antiflu-Des pharmaceutical companies:
References
- Dailymed."AMANTADINE HYDROCHLORIDE TABLET [ACTAVIS PHARMA, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."FEVERALL INFANTS (ACETAMINOPHEN) SUPPOSITORY [ACTAVIS MID ATLANTIC LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."WAL-FINATE (CHLORPHENIRAMINE MALEATE) TABLET [WALGREEN COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Antiflu-Des?Depending on the reaction of the Antiflu-Des after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Antiflu-Des not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Antiflu-Des addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Antiflu-Des, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Antiflu-Des consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Six visitors reported useful
How is the drug Antiflu-Des useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Useful | 5 | 83.3% | |
| Not useful | 1 | 16.7% | |
Two visitors reported side effects
Did you get side effects while taking the Antiflu-Des drug, or were there no side effects?According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Antiflu-Des medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
| Visitors | % | ||
|---|---|---|---|
| No side effects | 1 | 50.0% | |
| It has side effects | 1 | 50.0% | |
Two visitors reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Antiflu-Des is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Expensive | 1 | 50.0% | |
| Not expensive | 1 | 50.0% | |
Twelve visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Antiflu-Des drug as prescribed by the doctor?
Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Antiflu-Des is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| 3 times in a day | 6 | 50.0% | |
| Once in a day | 3 | 25.0% | |
| 4 times in a day | 2 | 16.7% | |
| Twice in a day | 1 | 8.3% | |
22 visitors reported doses
What is the dose of Antiflu-Des drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 201-500mg | 8 | 36.4% | |
| 6-10mg | 4 | 18.2% | |
| 11-50mg | 3 | 13.6% | |
| 501mg-1g | 2 | 9.1% | |
| 51-100mg | 2 | 9.1% | |
| 1-5mg | 2 | 9.1% | |
| 101-200mg | 1 | 4.5% | |
22 visitors reported time for results
What is the time duration Antiflu-Des drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Antiflu-Des drug. The time needed to show improvement in health condition after using the medicine Antiflu-Des need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 1 day | 7 | 31.8% | |
| 3 days | 6 | 27.3% | |
| 5 days | 4 | 18.2% | |
| 2 days | 3 | 13.6% | |
| 1 week | 1 | 4.5% | |
| 2 weeks | 1 | 4.5% | |
Fourteen visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Antiflu-Des drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| After food | 7 | 50.0% | |
| Empty stomach | 5 | 35.7% | |
| Before food | 1 | 7.1% | |
| With a meal | 1 | 7.1% | |
68 visitors reported age
| Visitors | % | ||
|---|---|---|---|
| 16-29 | 17 | 25.0% | |
| 30-45 | 17 | 25.0% | |
| 46-60 | 12 | 17.6% | |
| > 60 | 9 | 13.2% | |
| 6-15 | 7 | 10.3% | |
| 1-5 | 5 | 7.4% | |
| < 1 | 1 | 1.5% | |
Visitor reviews
| Hi. I wanted to know if antifludes has changed their pills color because suddenly they are all yellow not the two color yellow and purple or blue like he used to be ? Please answer me cause I want to know if they are fake ones I’m using. Thanks. |
The information was verified by Dr. Rachana Salvi, MD Pharmacology