Drugs & Supplements

Medication: Acnesone

Acnesone - A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

Indication: For the treatment and management of leprosy and dermatitis herpetiformis.

Acnesone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Acnesone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic carinii pneumonia in AIDS patients. Acnesone is absorbed rapidly and nearly completely from the gastrointestinal tract. Acnesone is distributed throughout total body water and is present in all tissues. However, it tends to be retained in skin and muscle and especially in the liver and kidney: traces of the drug are present in these organs up to 3 weeks after therapy cessation.

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