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DRUGS & SUPPLEMENTS
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Zopim
What are the side effects you encounter while taking this medicine? |
Zopim uses
Pharmacological action
Zopim is a sleeping drug from the group of imidazopyridine, specific agonist of omega1-receptors in CNS. It shortens the time to sleep, reduces the number of nighttime awakenings, increased sleep duration and improves its quality. This medication extends phase II of sleep, phases III and IV of deep sleep, does not affect the duration of REM sleep. Zolpidem characterized also by a central muscle relaxant and anticonvulsant effects.
Pharmacokinetics
After oral administration, Cmax plasma levels observed after 0.5-3 hours. Bioavailability is approximately 70%. Plasma protein binding is 92%. There is a linear relationship between the magnitude of the dose and concentration of the active substance in the plasma. Vd is 0.52-0.56 L / kg. Zolpidem is metabolized in the liver and in the form of inactive metabolites are excreted in the urine and feces (37%). It does not induce liver enzymes.
T1/2 is from 0.7 hours to 3.5 hours (mean is 2.4 h).
In elderly patients may decreases plasma clearance of zolpidem, while T1/2 increased slightly (to an average of 3 hours), Cmax increased by 50%, Vd decreased to 0.29-0.39 L / kg.
In patients with severe renal impairment the clearance of zolpidem is reduced slightly, other pharmacokinetic parameters were not changed. In patients with severe liver dysfunction increases the bioavailability of zolpidem, clearance is somewhat reduced, T1/2 increases to 10 hours.
Why is Zopim prescribed?
Episodic, transient and chronic insomnia.
Dosage and administration
For oral administration for adults aged under 65 years a single dose is 10 mg, if necessary, may increases to 15-20 mg. For patients older than 65 years or with concomitant hepatic insufficiency initial single dose is 5 mg. Zolpidem is taken just before bedtime. The course of treatment is from several days to 4 weeks. Maximum dose is 10 mg / day.
Zopim side effects, adverse reactions
Digestive system: in some cases - abdominal pain, nausea, vomiting, diarrhea.
CNS and peripheral nervous system: depending on the dose and individual sensitivity - vertigo, imbalance, ataxia, headache, daytime sleepiness, distraction, muscle weakness, double vision, anterograde amnesia, paradoxical or mental disorders; also it is possible ricochet insomnia when used in high doses or long-term treatment.
Allergic reactions: skin rash, itching.
Other: rarely - violation of sexual desire; development of addiction, the formation of psychic and physical dependence (when applying for a few weeks).
Contraindications
Severe respiratory failure, nocturnal apnea, severe hepatic insufficiency, childhood and adolescence to 15 years, I trimester of pregnancy, lactation (breastfeeding), increased sensitivity to zolpidem.
Using during pregnancy and breastfeeding
Zolpidem is contraindicated in pregnancy and lactation.
Special instructions
Zopim is not recommended for use with myasthenia gravis.
With careful use in patients with respiratory failure. In case of insufficiency of liver function may be necessary to decrease the dose.
If you cancel the therapy dose should be reduced gradually. The likelihood of habituation increases with prolonged use of zolpidem.
Avoid alcohol during the period of treatment.
During the period of treatment should refrain from potentially hazardous activities that require concentration and a high speed of psychomotor reactions.
Zolpidem drug interactions
When Zopim used with opioid analgesics, antitussives, barbiturates, antidepressants, sedatives, antihistamines, benzodiazepines, clonidine, neuroleptics, ethanol may develop symptoms of CNS depression and respiratory center.
When Zopim used with rifampicin, the concentration of zolpidem in the blood plasma, which is accompanied by a decrease in its hypnotic effect. Interaction is due to induction of isoenzyme CYP3A4.
Simultaneous administration with inducers of CYP3A4 isoenzyme may be possible reducing the concentration of zolpidem in the blood plasma.
Simultaneous administration with clozapine increases the risk of collapse, stop breathing and circulation.
Zopim in case of emergency / overdose
Symptoms: disturbance of consciousness (from lethargy to mild coma). There was recorded one case of cardiovascular and respiratory disorders; observed a full recovery after receiving doses of zolpidem tartrate up to 400 mg.
Treatment: immediate induction of vomiting or gastric lavage (depending on state), the appointment of activated carbon. Should abandon the use of any sedative drugs (even when expressed excitation). Hemodialysis is ineffective. Specific antidote is flumazenil (benzodiazepine receptor antagonist).
Zopim pharmaceutical active ingredients containing related brand and generic drugs:
Zopim available forms, composition, doses:
Zopim destination | category:
Zopim Anatomical Therapeutic Chemical codes:
Zopim pharmaceutical companies:
Frequently asked Questions
Can i drive or operate heavy machine after consuming Zopim?Depending on the reaction of the Zopim after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zopim not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Zopim addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Zopim, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zopim consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetOne visitor reported side effects
Did you get side effects while taking the Zopim drug, or were there no side effects?According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Zopim medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
| Visitors | % | ||
|---|---|---|---|
| No side effects | 1 | 100.0% | |
Visitor reported price estimates
No survey data has been collected yetVisitor reported frequency of use
No survey data has been collected yetFour visitors reported doses
What is the dose of Zopim drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 6-10mg | 4 | 100.0% | |
Two visitors reported time for results
What is the time duration Zopim drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 2 days to notice the result from using Zopim drug. The time needed to show improvement in health condition after using the medicine Zopim need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 2 days | 1 | 50.0% | |
| 5 days | 1 | 50.0% | |
Two visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Zopim drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| Empty stomach | 2 | 100.0% | |
Three visitors reported age
| Visitors | % | ||
|---|---|---|---|
| 46-60 | 2 | 66.7% | |
| 30-45 | 1 | 33.3% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology