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DRUGS & SUPPLEMENTS
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Apo-Trihex
What are the side effects you encounter while taking this medicine? |
Apo-Trihex uses
INDICATIONS AND USAGE
Apo-Trihex HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.
WARNINGS
Patients to be treated with Apo-Trihex HCl should have a gonioscope evaluation and close monitoring of intraocular pressures at regular periodic intervals.
PRECAUTIONS
Although Apo-Trihex HCl is not contraindicated for patients with cardiac, liver, or kidney disorders, or with hypertension, such patients should be maintained under close observation.
Since the use of Apo-Trihex HCl may, in some cases, continue indefinitely and since it has atropine-like properties, patients should be subjected to constant and careful long-term observation to avoid allergic and other untoward reactions. Inasmuch as Apo-Trihex HCl possesses some parasympatholytic activity, it should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy. Geriatric patients, particularly over the age of 60, frequently develop increased sensitivity to the actions of drugs of this type, and hence, require strict dosage regulation. Incipient glaucoma may be precipitated by parasympatholytic drugs such as Apo-Trihex HCl.
Tardive dyskinesia may appear in some patients on long-term therapy with antipsychotic drugs or may occur after therapy with these drugs has been discontinued. Antiparkinsonism agents do not alleviate the symptoms of tardive dyskinesia and, in some instances, may aggravate them. However, parkinsonism and tardive dyskinesia often coexist in patients receiving chronic neuroleptic treatment, and anticholinergic therapy with Apo-Trihex HCl may relieve some of these parkinsonism symptoms.
ADVERSE REACTIONS
Minor side effects, such as dryness of the mouth, blurring of vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with Apo-Trihex HCl than with belladonna alkaloids and are usually less disturbing than unalleviated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses.
Isolated instances of suppurative parotitis secondary to excessive dryness at the mouth, skin rashes, dilatation of the colon, paralytic ileus, and certain psychiatric manifestations such as delusions and hallucinations, plus one doubtful case of paranoia all of which may occur with any of the atropine-like drugs, have been reported rarely with Apo-Trihex hydrochloride.
Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached. If a severe reaction should occur, administration of the drug should be discontinued for a few days and then resumed at a lower dosage. Psychiatric disturbances can result from indiscriminate use (leading to overdosage) to sustain continued euphoria.
Potential side effects associated with the use of any atropine-like drugs include constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular tension, weakness, vomiting, and headache.
The occurrence of angle-closure glaucoma due to long-term treatment with Apo-Trihex has been reported.
DOSAGE AND ADMINISTRATION
Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether Apo-Trihex HCl may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If Apo-Trihex HCl tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.
Apo-Trihex HCl in Idiopathic Parkinsonism
As initial therapy for parkinsonism, 1 mg of Apo-Trihex in tablet form may be administered the first day. The dose may then be increased by 2 mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Many patients derive maximum benefit from this daily total of 6 to 10 mg, but some patients, chiefly those in the postencephalitic group, may require a total daily dose of 12 to 15 mg.
Apo-Trihex HCl in Drug-Induced Parkinsonism
The size and frequency of dose of Apo-Trihex HCl needed to control extrapyramidal reactions to commonly employed tranquilizers, notably the phenothiazines, thioxanthenes, and butyrophenones, must be determined empirically. The total daily dosage usually ranges between 5 and 15 mg, although, in some cases, these reactions have been satisfactorily controlled on as little as 1 mg daily. It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of the tranquilizer on instituting Apo-Trihex HCl therapy and then adjusting dosage of both drugs until the desired ataractic effect is retained without onset of extrapyramidal reactions.
It is sometimes possible to maintain the patient on a reduced Apo-Trihex HCl dosage after the reactions have remained under control for several days. Instances have been reported in which these reactions have remained in remission for long periods after Apo-Trihex HCl therapy was discontinued.
Concomitant Use of Apo-Trihex HCl with Levodopa
When Apo-Trihex HCl is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of symptom control. Apo-Trihex HCl dosage of 3 to 6 mg daily, in divided doses, is usually adequate.
Concomitant Use of Apo-Trihex HCl with Other Parasympathetic Inhibitors
Apo-Trihex HCl may be substituted, in whole or in part, for other parasympathetic inhibitors. The usual technique is partial substitution initially, with progressive reduction in the other medication as the dose of Apo-Trihex HCl is increased.
The total daily intake of Apo-Trihex HCl tablets is tolerated best if divided into 3 doses and taken at mealtimes. High doses (>10 mg daily) may be divided into 4 parts, with 3 doses administered at mealtimes and the fourth at bedtime.
HOW SUPPLIED
Apo-Trihex HCl tablets are available as follows:
2 mg – round, flat, scored, white tablets; debossed "5971" above the score and "V" below the score. Available in bottles of 100, 500 and 1000.
5 mg – round, flat, scored, white tablets; debossed "5972" above the score and "V" below the score. Available in bottles of 100, 500, and 1000.
Dispense in a tight, light-resistant container as defined in the USP.
Store at 20° to 25°C (68° to 77°F).
Manufactured for:
QUALITEST PHARMACEUTICALS
Huntsville, AL 35811
8181446
Rev 2/08
R2
Apo-Trihex pharmaceutical active ingredients containing related brand and generic drugs:
Apo-Trihex available forms, composition, doses:
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References
- Dailymed."TRIHEXYPHENIDYL HYDROCHLORIDE TABLET [QUALITEST PHARMACEUTICALS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "trihexyphenidyl". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "trihexyphenidyl". http://www.drugbank.ca/drugs/DB0037... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Apo-Trihex?Depending on the reaction of the Apo-Trihex after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Apo-Trihex not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Apo-Trihex addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Apo-Trihex, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Apo-Trihex consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetTwo visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Apo-Trihex drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Apo-Trihex is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 2 | 100.0% | |
Two visitors reported doses
What is the dose of Apo-Trihex drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 1-5mg | 1 | 50.0% | |
| 6-10mg | 1 | 50.0% | |
One visitor reported time for results
What is the time duration Apo-Trihex drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 week to notice the result from using Apo-Trihex drug. The time needed to show improvement in health condition after using the medicine Apo-Trihex need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 1 week | 1 | 100.0% | |
One visitor reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Apo-Trihex drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| After food | 1 | 100.0% | |
Two visitors reported age
| Visitors | % | ||
|---|---|---|---|
| 16-29 | 2 | 100.0% | |
Visitor reviews
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The information was verified by Dr. Rachana Salvi, MD Pharmacology