Ramic-M

Metoprolol:

• Pharmacological action
• Pharmacokinetics
• Why is Ramic-M prescribed?
• Dosage and administration
• Ramic-M (Metoprolol) side effects, adverse reactions
• Ramic-M contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Ramic-M drug interactions
• Ramic-M in case of emergency / overdose
• Ramic-M (Metoprolol) reviews

Pharmacological action

Ramic-M is a cardioselective beta1-blocker without intrinsic sympathomimetic activity. This medication has antihypertensive, antianginal and antiarrhythmic effect. Ramic-M (Metoprolol) decreases automaticity of sinus node, reducing heart rate, slows AV-conduction, decreases myocardial contractility and excitability, reduces cardiac output, reduces myocardial oxygen demand. This drug inhibits the stimulatory effect of catecholamines on the heart during physical and psycho-emotional stress.

Ramic-M (Metoprolol) causes a hypotensive effect which is stabilized by the end of the second week of a course. With angina Ramic-M (Metoprolol) reduces the frequency and severity of attacks.

This medicine also normalizes the heart rate during supraventricular tachycardia and atrial fibrillation; when myocardial infarction it contributes to limit the zone of ischemia of the heart muscle and reduces the risk of developing fatal arrhythmias, reduces the risk of recurrence of myocardial infarction. When Ramic-M (Metoprolol) is used in the medium therapeutic doses it has a less pronounced effect on smooth muscles of the bronchi and peripheral arteries than non-selective beta-blockers.

Pharmacokinetics

After oral administration Ramic-M (Metoprolol) is rapidly and almost completely absorbed from the gastrointestinal tract, C_max of the active substance in the blood plasma is reached after 1-2 hours. This medication intensively metabolized in the liver to form inactive metabolites. T_1/2 of Ramic-M (Metoprolol) from plasma is 3-4 h and during the course of treatment it does not change. More than 95% of the dose excreted by the kidneys of which only 3% is in unchanged form.

Why is Ramic-M prescribed?

Hypertension, prevention of angina, cardiac arrhythmias (supraventricular tachycardia, extrasystoles), secondary prevention after myocardial infarction, cardiac hyperkinetic syndrome (including in hyperthyroidism, NDCs). Prophylaxis of migraine.

Dosage and administration

For oral administration the average dose of Ramic-M is 100 mg / day in 1-2 reception. If necessary the daily dose gradually increased up to 200 mg. For IV injections a single dose is 2.5 mg, with no effect a re-introduction is possible in 5 minutes.

Maximum daily dose for oral administration is 400 mg, for IV injections a single dose is 15-20 mg.

Ramic-M (Metoprolol) side effects, adverse reactions

Cardiovascular system: possible bradycardia, hypotension, AV-conduction disturbances, symptoms of heart failure.

Digestive system: at the beginning of therapy may include dry mouth, nausea, vomiting, diarrhea, constipation, and in some cases - liver function abnormalities.

CNS and peripheral nervous system: at the beginning of therapy may be weakness, fatigue, dizziness, headache, muscle cramps, coldness and paresthesia in the extremities; possible reduction in the secretion of tear fluid, conjunctivitis, rhinitis, depression, sleep disturbances, nightmares.

Hemopoietic system: in some cases - thrombocytopenia.

Endocrine: hypoglycemic state in patients with diabetes.

Respiratory system: in predisposed patients may cause symptoms of bronchial obstruction.

Allergic reactions: skin rash, itching.

Ramic-M contraindications

AV-block II and III degree, sinoatrial block, bradycardia (heart rate below 50 beats / min), SSS, hypotension, chronic heart failure IIB-III stages, acute heart failure, cardiogenic shock, metabolic acidosis, pronounced disturbances of peripheral circulation, increased sensitivity to Ramic-M (Metoprolol).

Using during pregnancy and breastfeeding

Taking of Ramic-M during pregnancy is only possible if the intended benefits to the mother outweighs the potential risk to the fetus. This medication crosses the placental barrier. In connection with the possible development of a newborn bradycardia, hypotension, hypoglycemia, and respiratory failure, Ramic-M (Metoprolol) should be abolished for 48-72 hours before the scheduled date of delivery. After delivery it is necessary to ensure strict monitoring of the newborn within 48-72 hours.

Ramic-M (Metoprolol) in small amounts excreted in breast milk. The using during lactation is not recommended.

Special instructions

With careful use in patients with chronic obstructive airways disease, diabetes (especially during labile), Raynaud's disease and obliterative peripheral arterial disease, pheochromocytoma (to be used in combination with alpha-blockers), pronounced renal and liver functions impairment.

During treatment with Ramic-M (Metoprolol) a production of lacrimal fluid may decreases, which is important for patients who use contact lenses.

Completion of a long course of treatment with Ramic-M (Metoprolol) should be gradual (at least 10 days) under the supervision of a physician.

There is not recommended for concurrent use of Ramic-M (Metoprolol) with MAO inhibitors.

Combined therapy with clonidine should receive the later stop in a few days after discontinuation of Ramic-M (Metoprolol), in order to avoid a hypertensive crisis. Simultaneous administration of Ramic-M (Metoprolol) with hypoglycemic agents require correction of their dosing regimen.

A few days before the anesthesia it is necessary to stop taking this drug or find any anesthesia medication with minimal negative inotropic effects.

Patients whose work requires more attention, the application of Ramic-M (Metoprolol) outpatients should be addressed only after the evaluation of individual patient response.

Ramic-M drug interactions

Sympatholytics, nifedipine, nitroglycerin, diuretics, hydralazine and other antihypertensive drugs potentiate hypotension.

Antiarrhythmic and anesthetic medications increase the risk of bradycardia, arrhythmia, hypotension.

Digitalis drugs potentiate slowing AV conduction.

Simultaneously intravenous injection of verapamil and diltiazem may cause cardiac arrest.

Beta-adrenoceptor agonists, aminophylline, cocaine, estrogens, indomethacin and other NSAIDs impair antihypertensive effect.

Ramic-M (Metoprolol) enhances and prolongs the action of anti depolarizing muscle relaxants.

Combination with alcohol leads to mutual reinforcement of inhibitory effects on the CNS.

Allergens increased the risk of severe systemic allergic reactions or anaphylaxis.

Ramic-M (Metoprolol) edits the effectiveness of insulin and oral antidiabetic drugs and increases the risk of hypoglycemia.

Oral contraceptives, cimetidine, ranitidine, phenothiazines raise the level of this drug in the blood, rifampicin decreases it.

Ramic-M (Metoprolol) reduces the clearance of lidocaine, the effectiveness of beta 2-agonists (it is necessary to increase the dose of the latter).

This medicine is incompatible with MAO inhibitors of type A.

Ramic-M in case of emergency / overdose

Symptoms: hypotension, acute heart failure, bradycardia, heart block, AV block, cardiogenic shock, bronchospasm, trouble breathing and consciousness, coma, nausea, vomiting, generalized convulsions, cyanosis (manifest in 20 minutes - 2 hours after taking of Ramic-M (Metoprolol)).

Treatment: gastric lavage, the symptomatic therapy: atropine sulfate injection (IV fast 0.5-2 mg) if bradycardia and a violation of AV conduction; glucagon (1-10 mg IV, then IV infusion 2-2.5 mg / h) and dobutamine in the case of reduction of myocardial contractility; agonists (noradrenaline, adrenaline, etc.) when arterial hypotension; diazepam (IV slowly) to eliminate seizures; beta-agonists inhalation or IV jet injection of aminophylline to relieve broncho spastic reactions; cardioacceleration.

Ramipril:

• Ramic-M Karnataka Antibiotics & Pharmaceuticals information
• Ramic-M Karnataka Antibiotics & Pharmaceuticals indications
• Ramic-M Karnataka Antibiotics & Pharmaceuticals warnings
• Ramic-M Karnataka Antibiotics & Pharmaceuticals intake guidelines
• Ramic-M Karnataka Antibiotics & Pharmaceuticals dosage
• Ramic-M Karnataka Antibiotics & Pharmaceuticals overdose
• Ramic-M Karnataka Antibiotics & Pharmaceuticals missed dose
• Ramic-M Karnataka Antibiotics & Pharmaceuticals side effects
• Ramic-M Karnataka Antibiotics & Pharmaceuticals drug reactions
• Ramic-M (Ramipril) reviews

Ramic-M Karnataka Antibiotics & Pharmaceuticals information

Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals belongs to the class of drugs classified as ACE inhibitors or Angiotensin-Converting-Enzyme inhibitor.

Ramic-M Karnataka Antibiotics & Pharmaceuticals indications

This product is a drug prescribed for the treatment of hypertension or high blood pressure, and for the prevention of heart failures succeeding heart attacks. Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals is also used for the prevention of heart attacks, stroke and other heart related problems.

Ramic-M Karnataka Antibiotics & Pharmaceuticals warnings

The medication is major allergen especially to patients who have had histories of allergies. Ask for a skin test from your doctor if you are a person prone to allergies and more importantly if you are allergic to the components of Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals.

Before taking the medicine, inform your doctor if you have:

liver disease

kidney disease

And if you are on a salt restricted diet or taking salt substitutes, your doctor may lower you Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals dosage or even forbid you to take the drug.

Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals is also a grudge belonging to the pregnancy category D, which means that this medicine is a sure cause of birth defects in babies and may even cause death in the 2nd and third trimester of pregnancy.

The components of Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals are also passed through breast milk and the degree of harmful effects on the nursing infant is not known. Talk to your doctor first before deciding to take Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals if you are breast feeding.

Never take Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals when performing tasks that require mental and physical alertness such as driving or operating any kind of machinery. This medication is a powerful cause of drowsiness and dizziness.

Always maintain proper hydration when taking this medicine. Lack of fluids may cause low blood pressure and may enhance dizziness and fainting.

Ramic-M Karnataka Antibiotics & Pharmaceuticals intake guidelines

This medicine should be taken exactly as it is prescribed by your doctor.

Each dose must be taken with a full glass of water of about 6-8 ounces.

The intake of Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals can be with or without food.

Never stop medication without first consulting your doctor even if you begin to feel better, it still important that your termination of use of this medicine must be properly supervised by your doctor.

Ramic-M Karnataka Antibiotics & Pharmaceuticals dosage

The dosage of Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals can only be effectively determined by your doctor.

Ramic-M Karnataka Antibiotics & Pharmaceuticals overdose

If symptoms of overdose such as extreme drowsy and dizzy feeling, weakening, fainting and fatigue settles in, immediately seek medical help.

Ramic-M Karnataka Antibiotics & Pharmaceuticals missed dose

Do not take double doses of Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals; instead, skip the dose you missed especially if it near the time for the next dose.

Ramic-M Karnataka Antibiotics & Pharmaceuticals side effects

Possible side effects of Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals may include:

allergic reactions

difficulty in urinating

arrhythmia

changes in heartbeat

chest pains

severe drowsiness

sore throat

fever

headache

fatigue

dry tickling cough

nausea

vomiting

diarrhea

anxiety and depression

If you experience any of these side effects and if they become bothersome and intolerable, consult your doctor.

Ramic-M Karnataka Antibiotics & Pharmaceuticals drug reactions

This drug may react with drugs that contain potassium and potassium supplements such as K-Dur and Klor-Con.

Diuretics may also not work well with Ramic-M (Ramipril) Karnataka Antibiotics & Pharmaceuticals as well as water pills such as Lasix, Bumex and Lozol.