|
|||
|
DRUGS & SUPPLEMENTS
|
Oxetine
How old is patient? |
Oxetine uses
Pharmacological action
Oxetine is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Oxetine is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Oxetine apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Oxetine does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.
Pharmacokinetics
Oxetine absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Oxetine easily penetrates through the BBB.
Oxetine metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.
T1/2 of Oxetine is 2-3 days, norfluoxetine - 7-9 days.
Why is Oxetine prescribed?
Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.
Dosage and administration
The initial dose of Oxetine is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.
The maximum oral daily dose for adults is 80 mg.
Oxetine side effects, adverse reactions
CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.
Digestive system: diarrhea, nausea.
Metabolism: increased sweating, hypoglycemia, hyponatremia.
Reproductive system: decreased libido.
Allergic reactions: skin rash, itching.
Other: pain in joints and muscles, shortness of breath, increased body temperature.
Oxetine contraindications
Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Oxetine.
Using during pregnancy and breastfeeding
Oxetine is contraindicated during pregnancy and lactation.
Special instructions
Oxetine should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.
Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Oxetine increases the risk of epileptic seizures.
With the simultaneous application of Oxetine and electroconvulsive therapy may develop prolonged seizures.
Oxetine can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Oxetine before therapy MAO inhibitors should not be less than 5 weeks.
Elderly patients need correction of dosing regimen.
Safety of Oxetine in children has not been established.
During the period of treatment it needed to avoid use alcohol.
During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.
Oxetine drug interactions
Simultaneous administration of Oxetine with:
Oxetine in case of emergency / overdose
Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Oxetine (in combination with maprotiline, codeine, temazepam).
Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.
Oxetine pharmaceutical active ingredients containing related brand and generic drugs:
Oxetine available forms, composition, doses:
Oxetine destination | category:
Oxetine Anatomical Therapeutic Chemical codes:
Oxetine pharmaceutical companies:
References
- Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "fluoxetine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "fluoxetine". http://www.drugbank.ca/drugs/DB0047... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Oxetine?Depending on the reaction of the Oxetine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Oxetine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Oxetine addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Oxetine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Oxetine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Oxetine useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
Visitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetOne visitor reported frequency of use
How often in a day do you take the medicine?Are you taking the Oxetine drug as prescribed by the doctor?
Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Oxetine is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| 3 times in a day | 1 | 100.0% | |
Three visitors reported doses
What is the dose of Oxetine drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 11-50mg | 3 | 100.0% | |
One visitor reported time for results
What is the time duration Oxetine drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using Oxetine drug. The time needed to show improvement in health condition after using the medicine Oxetine need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| > 3 month | 1 | 100.0% | |
Visitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology