DRUGS & SUPPLEMENTS

Klexane

Name: Klexane drug & pharmaceuticals. Klexane available forms, doses, prices
Creator: sdrugs.com
Published: 2021-11-11T10:10:10+00:00

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Klexane is a low molecular weight heparin. Klexane is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. Klexane binds to and accelerates the activity of antithrombin III. By activating antithrombin III, Klexane preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin’s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.

Indication: For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.

Klexane is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from 3800 to 5000 daltons. Klexane occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Klexane is a well known and commonly used anticoagulant which has antithrombotic properties. Klexane inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Klexane acts at multiple sites in the normal coagulation system. Small amounts of Klexane in combination with antithrombin III (enoxaparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of Klexane can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Klexane also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor. Its use should be avoided in patients with a creatinine clearance less than 20mL/min. In these patients, unfractionated heparin should only be used. As for monitoring, active partial thromboplastin time (aPTT) will only increase at high doses of low molecular weight heparins (LMWH). Therefore, monitoring aPTT is not recommended. However, anti-Xa activity can be measured to monitor the efficacy of the LMWH.

Klexane pharmaceutical active ingredients containing related brand and generic drugs:

Enoxaparin Sodium

Klexane available forms, composition, doses:

Injectable; Injection; Enoxaparin Sodium 100 mg / ml
Injectable; Injection; Enoxaparin Sodium 150 mg / ml

Klexane destination | category:

Human:
Anticoagulants, antiplatelets and fibrinolytics (thrombolytics)
Heparins

Klexane Anatomical Therapeutic Chemical codes:

B01AB05 - Enoxaparin

Klexane pharmaceutical companies:

Sanofi-Aventis

References

Dailymed."LOVENOX (ENOXAPARIN SODIUM) INJECTION [SANOFI-AVENTIS U.S. LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
"enoxaparin". https://pubchem.ncbi.nlm.nih.gov/su... (accessed August 28, 2018).
"Enoxaparin - DrugBank". http://www.drugbank.ca/drugs/DB0122... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Klexane?

Depending on the reaction of the Klexane after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Klexane not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Klexane addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

sdrugs.com conducted a study on Klexane, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Klexane consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.