|
|||
|
DRUGS & SUPPLEMENTS
|
Doxy-Wolff
What is the dose of the medication you are taking? |
Doxy-Wolff uses
Doxy-Wolff consists of Doxycycline, Doxycycline Hyclate.Doxycycline:
Pharmacological action
Doxy-Wolff is an semisynthetic tetracycline group's antibiotic of broad-spectrum. This medication has bacteriostatic action due to suppression of protein synthesis of pathogens. It active against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.
Doxy-Wolff (Doxycycline) is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp. and Chlamydia spp.
Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis are resistant to Doxy-Wolff (Doxycycline).
Pharmacokinetics
After oral administration Doxy-Wolff (Doxycycline) is quickly and almost completely absorbed from the gastrointestinal tract. Ingestion has very little effect on the absorption of Doxy-Wolff (Doxycycline). This medication is widely distributed in tissues and body fluids. Plasma protein binding is 80-95%. T1/2 is 12-22 h. Doxy-Wolff (Doxycycline) excreted in the urine as unchanged (40%) but the main part of the dose excreted unchanged in the feces through bile secretion.
Why is Doxy-Wolff prescribed?
Infectious-inflammatory diseases caused by microorganisms sensitive to Doxy-Wolff (Doxycycline) including infections of the respiratory and ENT organs; gastrointestinal tract infections; purulent infections of skin and soft tissues (including acne); infection of the genitourinary system (including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.
Dosage and administration
Doxy-Wolff is indicated for adults orally or IV (infusions) in 200 mg / day dosess on the first day of treatment, in the coming days at 100-200 mg / day. Multiplicity of admission (or IV infusion) is 1-2 times / day. For children older than 8 years of age and weighing over 50 kg the daily Doxy-Wolff (Doxycycline) dose for oral administration or IV (infusion) in the first day of treatment is 4 mg / kg. In next days ir is 2-4 mg / kg depending on the severity of the clinical course of disease. Multiplicity of admission (or intravenous infusion) is 1-2 times / day. The recommended minimum time for IV infusion 100 mg of Doxy-Wolff (Doxycycline) (a concentration of infusion solution is 0.5 mg / ml) is 1 hour.
Maximum doses: for adults for oral administration is 300 mg / day or 600 mg / day (depending on the etiology of the agent); for iv injection it is 300 mg / day.
Doxy-Wolff (Doxycycline) side effects, adverse reactions
Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in the blood of hepatic transaminases, alkaline phosphatase, bilirubin.
Hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia, rarely - angioedema, photosensitivity.
Other: increased residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.
Doxy-Wolff contraindications
Pregnancy, children age up to 8 years (possibility of forming insoluble complexes with calcium in the skeleton, enamel and dentin of the teeth), hypersensitivity to tetracyclines, porphyria, severe liver insufficiency, leukopenia, lactation period, myasthenia (for IV administration).
Using during pregnancy and breastfeeding
Doxy-Wolff is contraindicated during pregnancy and lactation. Doxy-Wolff (Doxycycline) crosses the placental barrier. This medication may cause long-term discoloration of the teeth, enamel hypoplasia, inhibition of growth of bones of the fetus and also the development of fatty liver.
If necessary using during lactation patients should stop breastfeeding.
Special instructions
With careful use of Doxy-Wolff (Doxycycline) with impaired liver function. If a patient has renal impairment the dose adjustment is not required.
To prevent local irritating action (esophagitis, gastritis, gastrointestinal ultseratsiya) Doxy-Wolff (Doxycycline) should be taken during the day with plenty of fluids, food or milk. Due to possible development of photosensitivity it is necessary the restriction of insolation during treatment and for 4-5 days thereafter.
Doxy-Wolff (Doxycycline) is not used in children younger than 8 years because tetracyclines (including Doxy-Wolff (Doxycycline)) are causing long-term discoloration of the teeth, enamel hypoplasia and retardation of longitudinal growth of bones in these patients.
Doxy-Wolff (Doxycycline) solution for IV administration should be used no later than 72 hours after its preparation.
Doxy-Wolff drug interactions
Medications containing metal ions (antacids, products containing iron, magnesium, calcium) form inactive chelates with Doxy-Wolff (Doxycycline), in connection with what it is necessary to avoid their simultaneous use.
It needed to avoid combination with penicillins, cephalosporins, bactericidal action and is an antagonist of bacteriostatic antibiotics (including Doxy-Wolff (Doxycycline)).
Absorption of Doxy-Wolff (Doxycycline) is reduced by cholestyramine and colestipol (observe the interval between the reception of at least 3 h).
Due to suppression of intestinal microflora Doxy-Wolff (Doxycycline) reduces prothrombin index which requires dose adjustment of indirect anticoagulants.
Doxy-Wolff (Doxycycline) reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.
Simultaneous administration of Doxy-Wolff (Doxycycline) with:
Doxy-Wolff in case of emergency / overdose
Treatment: discontinuation, symptomatic and supportive therapy. Hemodialysis is ineffective.
Doxycycline Hyclate:
Pharmacological action
Doxy-Wolff is an semisynthetic tetracycline group's antibiotic of broad-spectrum. This medication has bacteriostatic action due to suppression of protein synthesis of pathogens. It active against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.
Doxy-Wolff (Doxycycline Hyclate) is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp. and Chlamydia spp.
Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis are resistant to Doxy-Wolff (Doxycycline Hyclate).
Pharmacokinetics
After oral administration Doxy-Wolff (Doxycycline Hyclate) is quickly and almost completely absorbed from the gastrointestinal tract. Ingestion has very little effect on the absorption of Doxy-Wolff (Doxycycline Hyclate). This medication is widely distributed in tissues and body fluids. Plasma protein binding is 80-95%. T1/2 is 12-22 h. Doxy-Wolff (Doxycycline Hyclate) excreted in the urine as unchanged (40%) but the main part of the dose excreted unchanged in the feces through bile secretion.
Why is Doxy-Wolff prescribed?
Infectious-inflammatory diseases caused by microorganisms sensitive to Doxy-Wolff (Doxycycline Hyclate) including infections of the respiratory and ENT organs; gastrointestinal tract infections; purulent infections of skin and soft tissues (including acne); infection of the genitourinary system (including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.
Dosage and administration
Doxy-Wolff is indicated for adults orally or IV (infusions) in 200 mg / day dosess on the first day of treatment, in the coming days at 100-200 mg / day. Multiplicity of admission (or IV infusion) is 1-2 times / day. For children older than 8 years of age and weighing over 50 kg the daily Doxy-Wolff (Doxycycline Hyclate) dose for oral administration or IV (infusion) in the first day of treatment is 4 mg / kg. In next days ir is 2-4 mg / kg depending on the severity of the clinical course of disease. Multiplicity of admission (or intravenous infusion) is 1-2 times / day. The recommended minimum time for IV infusion 100 mg of Doxy-Wolff (Doxycycline Hyclate) (a concentration of infusion solution is 0.5 mg / ml) is 1 hour.
Maximum doses: for adults for oral administration is 300 mg / day or 600 mg / day (depending on the etiology of the agent); for iv injection it is 300 mg / day.
Doxy-Wolff (Doxycycline Hyclate) side effects, adverse reactions
Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in the blood of hepatic transaminases, alkaline phosphatase, bilirubin.
Hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia, rarely - angioedema, photosensitivity.
Other: increased residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.
Doxy-Wolff contraindications
Pregnancy, children age up to 8 years (possibility of forming insoluble complexes with calcium in the skeleton, enamel and dentin of the teeth), hypersensitivity to tetracyclines, porphyria, severe liver insufficiency, leukopenia, lactation period, myasthenia (for IV administration).
Using during pregnancy and breastfeeding
Doxy-Wolff is contraindicated during pregnancy and lactation. Doxy-Wolff (Doxycycline Hyclate) crosses the placental barrier. This medication may cause long-term discoloration of the teeth, enamel hypoplasia, inhibition of growth of bones of the fetus and also the development of fatty liver.
If necessary using during lactation patients should stop breastfeeding.
Special instructions
With careful use of Doxy-Wolff (Doxycycline Hyclate) with impaired liver function. If a patient has renal impairment the dose adjustment is not required.
To prevent local irritating action (esophagitis, gastritis, gastrointestinal ultseratsiya) Doxy-Wolff (Doxycycline Hyclate) should be taken during the day with plenty of fluids, food or milk. Due to possible development of photosensitivity it is necessary the restriction of insolation during treatment and for 4-5 days thereafter.
Doxy-Wolff (Doxycycline Hyclate) is not used in children younger than 8 years because tetracyclines (including Doxy-Wolff (Doxycycline Hyclate)) are causing long-term discoloration of the teeth, enamel hypoplasia and retardation of longitudinal growth of bones in these patients.
Doxy-Wolff (Doxycycline Hyclate) solution for IV administration should be used no later than 72 hours after its preparation.
Doxy-Wolff drug interactions
Medications containing metal ions (antacids, products containing iron, magnesium, calcium) form inactive chelates with Doxy-Wolff (Doxycycline Hyclate), in connection with what it is necessary to avoid their simultaneous use.
It needed to avoid combination with penicillins, cephalosporins, bactericidal action and is an antagonist of bacteriostatic antibiotics (including Doxy-Wolff (Doxycycline Hyclate)).
Absorption of Doxy-Wolff (Doxycycline Hyclate) is reduced by cholestyramine and colestipol (observe the interval between the reception of at least 3 h).
Due to suppression of intestinal microflora Doxy-Wolff (Doxycycline Hyclate) reduces prothrombin index which requires dose adjustment of indirect anticoagulants.
Doxy-Wolff (Doxycycline Hyclate) reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.
Simultaneous administration of Doxy-Wolff (Doxycycline Hyclate) with:
Doxy-Wolff in case of emergency / overdose
Treatment: discontinuation, symptomatic and supportive therapy. Hemodialysis is ineffective.
Doxy-Wolff pharmaceutical active ingredients containing related brand and generic drugs:
Doxy-Wolff available forms, composition, doses:
Doxy-Wolff destination | category:
Doxy-Wolff Anatomical Therapeutic Chemical codes:
Doxy-Wolff pharmaceutical companies:
References
- Dailymed."ORACEA (DOXYCYCLINE) CAPSULE [GALDERMA LABORATORIES, L.P.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."DOXYCYCLINE HYCLATE CAPSULE, GELATIN COATED [WEST-WARD PHARMACEUTICALS CORP]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."DOXYCYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Doxy-Wolff?Depending on the reaction of the Doxy-Wolff after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Doxy-Wolff not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Doxy-Wolff addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Doxy-Wolff, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Doxy-Wolff consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetVisitor reported frequency of use
No survey data has been collected yetVisitor reported doses
No survey data has been collected yetVisitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology