DRUGS & SUPPLEMENTS

Dimercaprol

Name: Dimercaprol drug & pharmaceuticals. Available Forms, Doses, Prices
Creator: sdrugs.com
Published: 2021-11-11T10:10:10+00:00

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Dimercaprol uses

Description
Clinical pharmacology
Indications
Contraindications
Warnings
Precautions
Adverse reactions
Drug abuse and dependence
Overdose
Dosage and administration
How supplied
Animal toxicology
Dimercaprol reviews

Dimercaprol (2,3-dimercapto-1-propanol) 10%, Benzyl Benzoate 20%, in Peanut Oil

Rx only

structural formula

DESCRIPTION

Dimercaprol Injection USP is a colorless or almost colorless liquid chelating agent having a disagreeable, mercaptan-like odor. Each 1 mL sterile Dimercaprol in Oil (Dimercaprol Injection USP) contains: 100 mg Dimercaprol in 200 mg Benzyl Benzoate and 700 mg Peanut Oil.

CLINICAL PHARMACOLOGY

The sulfhydryl groups of Dimercaprol form complexes with certain heavy metals thus preventing or reversing the metallic binding of sulfhydryl-containing enzymes. The complex is excreted. The sustained presence of Dimercaprol promotes continued excretion of the metallic poisons - arsenic, gold and mercury. It is also used in combination with Edetate Calcium Disodium Injection USP to promote the excretion of lead.

INDICATIONS

Dimercaprol in Oil (Dimercaprol Injection USP) is indicated in the treatment of arsenic, gold and mercury poisoning. It is indicated in acute lead poisoning when used concomitantly with Edetate Calcium Disodium Injection USP.

Dimercaprol Injection USP is effective for use in acute poisoning by mercury salts if therapy is begun within one or two hours following ingestion. It is not very effective for chronic mercury poisoning.

Dimercaprol Injection USP is of questionable value in poisoning caused by other heavy metals such as antimony and bismuth. It should not be used in iron, cadmium, or selenium poisoning because the resulting dimercaprol-metal complexes are more toxic than the metal alone, especially to the kidneys.

CONTRAINDICATIONS

Dimercaprol in Oil (Dimercaprol Injection USP) is contraindicated in most instances of hepatic insufficiency with the exception of postarsenical jaundice. The drug should be discontinued or used only with extreme caution if acute renal insufficiency develops during therapy.

WARNINGS

There may be local pain at the site of the injection. A reaction apparently peculiar to children is fever which may persist during therapy. It occurs in approximately 30% of children. A transient reduction of the percentage of polymorphonuclear leukocytes may also be observed.

PRECAUTIONS

Because the dimercaprol-metal complex breaks down easily in an acid medium, production of an alkaline urine affords protection to the kidney during therapy. Medicinal iron should not be administered to patients under therapy with Dimercaprol in Oil.

Dimercaprol in Oil Ampules is formulated with peanut oil. Peanut oil may cause allergic reactions in some individuals. Physicians should use caution in prescribing Dimercaprol in Oil Ampules for peanut-sensitive patients. Medication and equipment necessary to treat allergic reactions should be available if the product is administered to peanut-allergic patients.

Pregnancy Category C

Animal reproduction studies have not been conducted with Dimercaprol in Oil. It is also not known whether Dimercaprol in Oil can cause fetal harm when administered to a pregnant woman, or can affect reproduction capacity. Dimercaprol in Oil should be given to a pregnant woman only if clearly needed.

It is not known whether this drug is excreted in human milk. However, because many drugs are excreted in human milk, caution should be exercised when Dimercaprol in Oil is administered to a nursing woman.

ADVERSE REACTIONS

One of the most consistent responses to Dimercaprol Injection USP is a rise in blood pressure accompanied by tachycardia. This rise is roughly proportional to the dose administered. Doses larger than those recommended may cause other transitory signs and symptoms in approximate order of frequency as follows: (1) nausea and, in some instance, vomiting; (2) headache; (3) a burning sensation in the lips, mouth and throat; (4) a feeling of constriction, even pain, in the throat, chest, or hands; (5) conjunctivitis, lacrimation, blepharal spasm, rhinorrhea, and salivation; (6) tingling of the hands; (7) a burning sensation in the penis; (8) sweating of the forehead, hands and other areas; (9) abdominal pain; and (10) occasional appearance of painful sterile abscesses. Many of the above symptoms are accompanied by a feeling of anxiety, weakness, and unrest and often are relieved by administration of antihistamine.

DRUG ABUSE AND DEPENDENCE

Dimercaprol Injection USP is not a controlled substance listed in any other Drug Enforcement Administration schedules. Its use is not known to lead to dependence or abuse.

OVERDOSE

Dosage exceeding 5 mg/kg will usually be followed by vomiting, convulsions and stupor, beginning within 30 minutes and subsiding within 6 hours following injection.

AMER. HOSP. FORM. SERV., 64:00, Amer. Soc. Hosp. Pharm., 1977.

DOSAGE AND ADMINISTRATION

By deep intramuscular injection only. For mild arsenic or gold poisoning, 2.5 mg/kg of body weight four times daily for two days, two times on the third day, and once daily thereafter for ten days; for severe arsenic or gold poisoning, 3 mg/kg every four hours for two-days, four times on the third day, then twice daily thereafter for ten days. For mercury poisoning, 5 mg/kg initially, followed by 2.5 mg/kg one or two times daily for ten days. For acute lead encephalopathy, 4 mg/kg body weight is given alone in the first dose and thereafter at four-hour intervals in combination with Edetate Calcium Disodium Injection USP administered at a separate site. For less severe poisoning the dose can be reduced to 3 mg/kg after the first dose. Treatment is maintained for two to seven days depending on clinical response. Successful treatment depends on beginning injections at the earliest possible moment and on the use of adequate amounts at frequent intervals. Other supportive measures should always be used in conjunction with Dimercaprol in Oil (Dimercaprol Injection USP) therapy.

Dimercaprol in Oil should be inspected visually for particulate matter and discoloration prior to administration.

HOW SUPPLIED

3 mL (100 mg/mL) ampules, box of 10 (NDC 17478-526-03).

STORAGE: Store at 20° to 25°C (68° to 77°F).

ANIMAL TOXICOLOGY

The intramuscular LD₅₀ in rats is approximately 105 mg/kg; intraperitoneally 140 mg/kg. The intraperitoneal LD₈₀ in mice is approximately 125 mg/kg.

JR. PHARM. EXPER. THER., 87, Supplement Aug. 1946.

Akorn

Manufactured by: Akorn, Inc.

Lake Forest, IL 60045

BL00N Rev. 10/08

Principal Display Panel Text for Container Label:

NDC 17478-526-03

Dimercaprol in Oil

Dimercaprol INJECTION, USP

100 mg/mL

For IM Use Only

Rx only 3 mL Ampule

Akorn Logo

Principal Display Panel Text for Carton Label:

NDC 17478-526-03

Dimercaprol in Oil

Dimercaprol INJECTION, USP

100 mg/mL

For Intramuscular Injection Only

10 Ampules (3 mL each)

Rx only Akorn Logo

Dimercaprol pharmaceutical active ingredients containing related brand and generic drugs:

Dimercaprol

Dimercaprol available forms, composition, doses:

Injectable; Injection; Dimercaprol 5%

Dimercaprol destination | category:

Human:
Antidotes
Detoxifying agents and drugs used in substance dependence
Heavy metal antagonists

Dimercaprol Anatomical Therapeutic Chemical codes:

V03AB09 - Dimercaprol

Dimercaprol pharmaceutical companies:

References

Dailymed."BAL (DIMERCAPROL) INJECTION [AKORN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Dailymed."DIMERCAPROL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
"DIMERCAPROL". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Dimercaprol?

Depending on the reaction of the Dimercaprol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Dimercaprol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Dimercaprol addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

sdrugs.com conducted a study on Dimercaprol, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Dimercaprol consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.