Algio-Truxa

Acetaminophen:

• Pharmacological action
• Why is Algio-Truxa (Acetaminophen) prescribed?
• Algio-Truxa dosage and administration
• Algio-Truxa side effects, adverse reactions
• Contraindications
• Using during pregnancy and breastfeeding
• Special Instructions
• Algio-Truxa (Acetaminophen) Drug Interactions
• Algio-Truxa in case of emergency / overdose
• Algio-Truxa (Acetaminophen) reviews

Pharmacological action

Algio-Truxa is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Algio-Truxa (Acetaminophen) prescribed?

Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.

Algio-Truxa dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Algio-Truxa side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Algio-Truxa, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).

Using during pregnancy and breastfeeding

Algio-Truxa (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Algio-Truxa (Acetaminophen) on the fetus in humans.

Algio-Truxa (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Algio-Truxa (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Algio-Truxa (Acetaminophen).

Special Instructions

Algio-Truxa is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Algio-Truxa (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).

Algio-Truxa (Acetaminophen) Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Algio-Truxa (Acetaminophen).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Algio-Truxa (Acetaminophen).

With the simultaneous use of oral contraceptives accelerated excretion of Algio-Truxa (Acetaminophen) from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Algio-Truxa (Acetaminophen).

When Algio-Truxa (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Algio-Truxa (Acetaminophen). A case of severe toxic liver injury.

Described cases of toxic effects of Algio-Truxa (Acetaminophen), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Algio-Truxa (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Algio-Truxa (Acetaminophen) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Algio-Truxa (Acetaminophen) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Algio-Truxa (Acetaminophen) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Algio-Truxa (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Algio-Truxa (Acetaminophen) due to increasing its metabolism in the liver.

At simultaneous application of Algio-Truxa (Acetaminophen) with ethinylestradiol increases absorption of Algio-Truxa (Acetaminophen) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Algio-Truxa in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

Piroxicam:

• Pharmacological action
• Pharmacokinetics
• Why is Algio-Truxa prescribed?
• Dosage and administration
• Algio-Truxa side effects, adverse reactions
• Algio-Truxa contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Algio-Truxa drug interactions
• Algio-Truxa in case of emergency / overdose
• Algio-Truxa (Piroxicam) reviews

Pharmacological action

Algio-Truxa is a NSAID, refers to a group oxicams. This medication has anti-inflammatory, analgesic and antipyretic effect.

The mechanism of action associated with inhibition of the enzyme COX, which leads to inhibition of prostaglandin synthesis from arachidonic acid.

Algio-Truxa (Piroxicam) inhibits the aggregation of platelets. For systemic use this medicine reduces the pain syndrome.

When Algio-Truxa (Piroxicam) used externally it weakens or suppresses inflammation and joint pain at rest and in motion, reduces morning stiffness and swelling of the joints, increases range of motion.

The analgesic effect occurs within 30 minutes after oral taking. Anti-inflammatory effect manifested by the end of the first week of treatment. After a single dose the effect lasts for 24 hours.

Pharmacokinetics

After oral administration Algio-Truxa (Piroxicam) is well absorbed from the gastrointestinal tract. Cmax in plasma is reached within 3-5 hours.

The proteins plasma binding is 99%. Algio-Truxa (Piroxicam) penetrating the placental barrier, excrets in breast milk.

Metabolized in the liver by hydrolysis and conjugation. Algio-Truxa (Piroxicam) is excreted unchanged (5%) and in the form of metabolites, which are displayed in the kidneys and in small amounts in feces. T_1/2 is approximately 50 hours.

In patients with liver diseases T_1/2 may increases.

Why is Algio-Truxa prescribed?

For systemic and topical use: articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), back pain, neuralgia, myalgia, traumatic inflammation of the soft tissue and musculoskeletal system.

For systemic use: dysmenorrhea in patients older than 12 years, acute infectious-inflammatory diseases of upper respiratory tract.

Dosage and administration

For oral administration the dosage is 10-30 mg 1 time / day. Rectal - 20-40 mg 1-2 times / day. In acute gout, the initial dose is 40 mg 1 time / day in the first 2 days, then 40 mg 1 time per day or 20 mg 2 times / day for 4-6 days. In acute conditions or exacerbation of a chronic process you can enter IM at a dose of 20-40 mg 1 time / day. After the relief of acute process of switching to maintenance therapy with oral forms.

Externally this medicine is applied 3-4 times / day.

Algio-Truxa side effects, adverse reactions

Digestive system: common - nausea, anorexia, stomatitis, epigastric pain, diarrhea or constipation, bloating, bleeding gums (due to the inhibition of platelet aggregation); in rare cases - erosive and ulcerative lesions of the gastrointestinal tract, with possible bleeding and perforation, transient elevation of liver enzymes, jaundice and hepatic necrosis with fatal consequences. Typically these side effects develop with chronic administration at doses exceeding 30 mg / day.

Hematopoietic system: anemia (rarely aplastic anemia or hemolytic anemia), thrombocytopenia, leukopenia, eosinophilia.

CNS and peripheral nervous system: possible dizziness, headache, drowsiness, sleep disturbances, depression, anxiety, hallucinations, mood changes, weakness, disturbances of sensitivity, swelling of the eyes, blurred vision, and signs of eye irritation.

Metabolism: rarely - hyperkalemia, hypo- or hyperglycemia, changes in body weight, in some cases - a transient increase of residual nitrogen and creatinine, uremia with hyperkalemia.

Urinary system: acute renal failure (with symptoms of hemorrhagic vasculitis), acute interstitial nephritis.

Allergic reactions: possible itching, redness, rash, pemphigus vulgaris, allergic swelling of face and hands; in some cases - Stevens-Johnson syndrome, Lyell's syndrome; in rare cases - anaphylactic reactions, bronchospasm, urticaria, angioedema, vasculitis, serum sickness.

Dermatological reactions: rarely - photosensitivity, rarely - onycholysis, alopecia.

Other: possible nosebleeds.

Local reaction: possible irritation of the rectum, tenesmus.

For external use: rarely - erythema and itching at the site of application.

Algio-Truxa contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in acute phase, indications in a history to bronchial asthma in connection with the use of NSAIDs, violations of porphyrin metabolism, expressed by human liver and kidney failure, pregnancy, lactation, children under the age of 14 years, proctitis (rectal use), increased sensitivity to Algio-Truxa (Piroxicam).

Using during pregnancy and breastfeeding

Algio-Truxa is contraindicated for use in the III trimester of pregnancy. If necessary to use this drug in the I and II trimesters of pregnancy should be related to the expected benefit to the mother and the potential risk to the fetus, due to lack of reliable clinical evidence supporting the safety of Algio-Truxa (Piroxicam) in this period.

Algio-Truxa (Piroxicam) is excreted in breast milk. If necessary to use this medication during lactation should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.

Special instructions

With caution use Algio-Truxa (Piroxicam) if erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, dyspeptic symptoms of chronic heart failure, hepatic dysfunction and kidney failure, asthma, coagulation disorders, and concomitant administration of oral anticoagulants, allergic reactions to acetylsalicylic acid and other NSAIDs in history.

In the course of treatment is necessary to monitor the functional state of the liver and peripheral blood picture. This medicine should not be used topically in violation of the integrity of the skin.

Must avoid contact with eyes or mucous membranes.

Not recommended for use while Algio-Truxa (Piroxicam) and acetylsalicylic acid and other NSAIDs.

Algio-Truxa drug interactions

This medication Displaces from its association with blood proteins other drugs; reduces the effectiveness of antihypertensive drugs. Compared to other NSAIDs and corticosteroids Algio-Truxa (Piroxicam) increases the risk of ulcerogenic action. This drug increases the risk of hyperkalemia when combined with potassium-sparing potassium-based diuretics and other drugs; increases the concentration of phenytoin and lithium in the blood. Anticoagulants increase the risk of bleeding. Aspirin reduces the concentration of Algio-Truxa (Piroxicam) in the blood up to 80% of the original.

Algio-Truxa in case of emergency / overdose

Symptoms: drowsiness, blurred vision, at very high doses - loss of consciousness, coma.

Treatment: gastric lavage, taking activated charcoal, antacids (to reduce the intake), symptomatic therapy.