Fluzone Trivalent Subvirion

A :

• Fluzone Trivalent Subvirion information
• Fluzone Trivalent Subvirion indications
• Fluzone Trivalent Subvirion warnings
• Fluzone Trivalent Subvirion intake guidelines
• Fluzone Trivalent Subvirion dosage
• Fluzone Trivalent Subvirion overdose
• Fluzone Trivalent Subvirion missed dose
• Fluzone Trivalent Subvirion side effects
• Fluzone Trivalent Subvirion drug reactions
• Fluzone Trivalent Subvirion (A ) reviews

Fluzone Trivalent Subvirion information

Fluzone Trivalent Subvirion (A ) is Fluzone Trivalent Subvirion (A ) topical form of vitamin Fluzone Trivalent Subvirion (A ). This vitamin is known for its ability to help the skin gradually renew itself. This medicine is mostly used in the treatment of acne, but it is sometimes prescribed to reduce the appearance of mottled skin discoloration and fine wrinkles (to make the patient's facial skin from rough to smooth and silky).

Fluzone Trivalent Subvirion indications

Fluzone Trivalent Subvirion (A ) is Fluzone Trivalent Subvirion (A ) popular topical form of vitamin Fluzone Trivalent Subvirion (A ) that has proven itself to be highly effective in the treatment of acne. However, this medicine might also be used to treat or to prevent the appearance of some other medical disorders that have not been listed here.

Fluzone Trivalent Subvirion warnings

Fluzone Trivalent Subvirion (A ) is Fluzone Trivalent Subvirion (A ) category C FDA pregnancy drug. Therefore, using this medicine during pregnancy could harm Fluzone Trivalent Subvirion (A ) growing fetus. Before you start Fluzone Trivalent Subvirion (A ) treatment with this medicine, you must inform your personal physician if you are pregnant or if you are planning to be so soon. It has been determined that this medicine's main ingredients are able to pass into breastmilk. Ask your personal physician if it is safe to start using Fluzone Trivalent Subvirion (A ) if you are currently nursing an infant.

During your treatment with Fluzone Trivalent Subvirion (A ) you should avoid prolonged and unprotected exposure to artificial UV rays (tanning beds or sunlamps) or to direct sunlight. Fluzone Trivalent Subvirion (A ) treatment with this medicine is known to increase the patient's skin's sensitivity to direct sunlight, thus leading to severe sunburn. However, if you cannot avoid exposure to sunlight, sunlamps or tanning beds, you must use an effective sunscreen (at least SPF 15). It is recommended that you should wear protective clothing. Avoid letting this medication get in direct contact with your eyes, nose, mouth or with your lips. However, if Fluzone Trivalent Subvirion (A ) small amount of this medicine somehow gets into contact with any of the areas that have been listed here, you should wash it with plenty of water.

You must avoid using Fluzone Trivalent Subvirion (A ) on windburned, sunburned, irritated, chapped, or broken skin or on skin areas that are suffering from any forms of Eczema. If you do have any of these medical conditions you should first wait for them to heal before you consider using this medicine. Do not stop your treatment with Fluzone Trivalent Subvirion (A ) without your physician's approval even if you start to feel better after Fluzone Trivalent Subvirion (A ) few days of treatment (in some cases, the symptoms improve even if the infection has not completely healed). Some patients have to use this medicine for several months before they can finally see the results of their treatment. If you have been prescribed this drug to treat acne, your skin condition might worsen for Fluzone Trivalent Subvirion (A ) short period of time at the beginning of the treatment. If this persists for more than 12 weeks or if your medical condition has not improved after 3 months of treatment you must alert your personal physician.

Fluzone Trivalent Subvirion intake guidelines

You ought to use this drug exactly how your personal doctor has prescribed you to. You can consult the medicine's label if you want to get further information. If you fail to understand some of the physician's instructions, you should contact Fluzone Trivalent Subvirion (A ) pharmacist, Fluzone Trivalent Subvirion (A ) nurse or Fluzone Trivalent Subvirion (A ) doctor and ask them to explain them to you. Using Fluzone Trivalent Subvirion (A ) higher dose of this medicine or applying the drug more often than your personal physician has prescribed you to, will not make the results appear faster (it might increase this Fluzone Trivalent Subvirion (A ) Acido's unpleasant side effects). You must wash both your hands after and before you apply Fluzone Trivalent Subvirion (A ). Before you apply the medicine you should make sure that the skin area that you are about to treat is both clean and dry. Applying this medicine on Fluzone Trivalent Subvirion (A ) wet skin area can sometimes cause skin irritation.

You must not wash the skin area that you have treated with Fluzone Trivalent Subvirion (A ) for at least 60 minutes after applying the medicine. Avoid using any other type of skin products on the skin area that you have treated with this drug for at least 1 hour after using this drug topical. This medicine should be stored in Fluzone Trivalent Subvirion (A ) cool and dry place, away from heat, moisture and direct sunlight. Keep it in Fluzone Trivalent Subvirion (A ) place that is far from the reach of pets and children in order to avoid unwanted accidents such as poisoning. This medicine is highly flammable. Keep the drug container away from any open flame.

Fluzone Trivalent Subvirion dosage

Ask your personal physician to calculate the dose of this medicine that works best for your condition. Do not make any alterations to the dose of Fluzone Trivalent Subvirion (A ) that you have been prescribed without your physician's approval.

Fluzone Trivalent Subvirion overdose

If you suspect that you are suffering from an overdose with this medicine, you are probably in need of emergency medical care. Contact your local poison control center and your personal physician as soon as you can. An overdose with this medicine should not trigger any unpleasant symptoms.

Fluzone Trivalent Subvirion missed dose

In order to get the most benefits from your treatment with Fluzone Trivalent Subvirion (A ) you should take it on Fluzone Trivalent Subvirion (A ) regular basis. If you miss one of your prescribed doses of this medicine you should take it as soon as you remember. If it is already time for another prescribed dose, skip the one that you have missed and proceed with your regular treatment. Avoid using extra doses of this medicine without first consulting it with your personal physician.

Fluzone Trivalent Subvirion side effects

Alert your doctor if you experience anything bothersome during your treatment with Fluzone Trivalent Subvirion (A ).

Fluzone Trivalent Subvirion drug reactions

Ask your personal physician if it is safe to take any other medicines while using Fluzone Trivalent Subvirion (A ).

A :

• Fluzone Trivalent Subvirion information
• Fluzone Trivalent Subvirion indications
• Fluzone Trivalent Subvirion warnings
• Fluzone Trivalent Subvirion intake guidelines
• Fluzone Trivalent Subvirion dosage
• Fluzone Trivalent Subvirion overdose
• Fluzone Trivalent Subvirion missed dose
• Fluzone Trivalent Subvirion side effects
• Fluzone Trivalent Subvirion drug reactions
• Fluzone Trivalent Subvirion (A ) reviews

Fluzone Trivalent Subvirion information

Fluzone Trivalent Subvirion (A ) is Fluzone Trivalent Subvirion (A ) topical form of vitamin Fluzone Trivalent Subvirion (A ). This vitamin is known for its ability to help the skin gradually renew itself. This medicine is mostly used in the treatment of acne, but it is sometimes prescribed to reduce the appearance of mottled skin discoloration and fine wrinkles (to make the patient's facial skin from rough to smooth and silky).

Fluzone Trivalent Subvirion indications

Fluzone Trivalent Subvirion (A ) is Fluzone Trivalent Subvirion (A ) popular topical form of vitamin Fluzone Trivalent Subvirion (A ) that has proven itself to be highly effective in the treatment of acne. However, this medicine might also be used to treat or to prevent the appearance of some other medical disorders that have not been listed here.

Fluzone Trivalent Subvirion warnings

Fluzone Trivalent Subvirion (A ) is Fluzone Trivalent Subvirion (A ) category C FDA pregnancy drug. Therefore, using this medicine during pregnancy could harm Fluzone Trivalent Subvirion (A ) growing fetus. Before you start Fluzone Trivalent Subvirion (A ) treatment with this medicine, you must inform your personal physician if you are pregnant or if you are planning to be so soon. It has been determined that this medicine's main ingredients are able to pass into breastmilk. Ask your personal physician if it is safe to start using Fluzone Trivalent Subvirion (A ) if you are currently nursing an infant.

During your treatment with Fluzone Trivalent Subvirion (A ) you should avoid prolonged and unprotected exposure to artificial UV rays (tanning beds or sunlamps) or to direct sunlight. Fluzone Trivalent Subvirion (A ) treatment with this medicine is known to increase the patient's skin's sensitivity to direct sunlight, thus leading to severe sunburn. However, if you cannot avoid exposure to sunlight, sunlamps or tanning beds, you must use an effective sunscreen (at least SPF 15). It is recommended that you should wear protective clothing. Avoid letting this medication get in direct contact with your eyes, nose, mouth or with your lips. However, if Fluzone Trivalent Subvirion (A ) small amount of this medicine somehow gets into contact with any of the areas that have been listed here, you should wash it with plenty of water.

You must avoid using Fluzone Trivalent Subvirion (A ) on windburned, sunburned, irritated, chapped, or broken skin or on skin areas that are suffering from any forms of Eczema. If you do have any of these medical conditions you should first wait for them to heal before you consider using this medicine. Do not stop your treatment with Fluzone Trivalent Subvirion (A ) without your physician's approval even if you start to feel better after Fluzone Trivalent Subvirion (A ) few days of treatment (in some cases, the symptoms improve even if the infection has not completely healed). Some patients have to use this medicine for several months before they can finally see the results of their treatment. If you have been prescribed this drug to treat acne, your skin condition might worsen for Fluzone Trivalent Subvirion (A ) short period of time at the beginning of the treatment. If this persists for more than 12 weeks or if your medical condition has not improved after 3 months of treatment you must alert your personal physician.

Fluzone Trivalent Subvirion intake guidelines

You ought to use this drug exactly how your personal doctor has prescribed you to. You can consult the medicine's label if you want to get further information. If you fail to understand some of the physician's instructions, you should contact Fluzone Trivalent Subvirion (A ) pharmacist, Fluzone Trivalent Subvirion (A ) nurse or Fluzone Trivalent Subvirion (A ) doctor and ask them to explain them to you. Using Fluzone Trivalent Subvirion (A ) higher dose of this medicine or applying the drug more often than your personal physician has prescribed you to, will not make the results appear faster (it might increase this Fluzone Trivalent Subvirion (A ) Acido's unpleasant side effects). You must wash both your hands after and before you apply Fluzone Trivalent Subvirion (A ). Before you apply the medicine you should make sure that the skin area that you are about to treat is both clean and dry. Applying this medicine on Fluzone Trivalent Subvirion (A ) wet skin area can sometimes cause skin irritation.

You must not wash the skin area that you have treated with Fluzone Trivalent Subvirion (A ) for at least 60 minutes after applying the medicine. Avoid using any other type of skin products on the skin area that you have treated with this drug for at least 1 hour after using this drug topical. This medicine should be stored in Fluzone Trivalent Subvirion (A ) cool and dry place, away from heat, moisture and direct sunlight. Keep it in Fluzone Trivalent Subvirion (A ) place that is far from the reach of pets and children in order to avoid unwanted accidents such as poisoning. This medicine is highly flammable. Keep the drug container away from any open flame.

Fluzone Trivalent Subvirion dosage

Ask your personal physician to calculate the dose of this medicine that works best for your condition. Do not make any alterations to the dose of Fluzone Trivalent Subvirion (A ) that you have been prescribed without your physician's approval.

Fluzone Trivalent Subvirion overdose

If you suspect that you are suffering from an overdose with this medicine, you are probably in need of emergency medical care. Contact your local poison control center and your personal physician as soon as you can. An overdose with this medicine should not trigger any unpleasant symptoms.

Fluzone Trivalent Subvirion missed dose

In order to get the most benefits from your treatment with Fluzone Trivalent Subvirion (A ) you should take it on Fluzone Trivalent Subvirion (A ) regular basis. If you miss one of your prescribed doses of this medicine you should take it as soon as you remember. If it is already time for another prescribed dose, skip the one that you have missed and proceed with your regular treatment. Avoid using extra doses of this medicine without first consulting it with your personal physician.

Fluzone Trivalent Subvirion side effects

Alert your doctor if you experience anything bothersome during your treatment with Fluzone Trivalent Subvirion (A ).

Fluzone Trivalent Subvirion drug reactions

Ask your personal physician if it is safe to take any other medicines while using Fluzone Trivalent Subvirion (A ).

Panama :

• Pharmacological action
• Pharmacokinetics
• Why is Fluzone Trivalent Subvirion prescribed?
• Dosage and administration
• Fluzone Trivalent Subvirion ( Panama ) side effects
• Contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Fluzone Trivalent Subvirion ( Panama ) drug interactions
• Fluzone Trivalent Subvirion in case of emergency / overdose
• Storage conditions
• Fluzone Trivalent Subvirion ( Panama ) reviews

Pharmacological action

NSAIDs, a derivative of phenylacetic acid, diclofenac has a pronounced anti-inflammatory, analgesic and mild antipyretic effect. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. Analgesic effect is due to two mechanisms: peripheral and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Inhibits synthesis of proteoglycan in cartilage.

In rheumatic diseases, diclofenac reduces joint pain at rest and in motion, as well as morning stiffness and swelling of the joints, helps to increase range of motion; reduces post-traumatic and postoperative pain, and inflammatory edema.

Inhibits platelet aggregation. With prolonged use has a desensitizing effect.

When used topically in ophthalmology reduces swelling and pain in inflammatory processes non-infectious etiology.

Pharmacokinetics

After intake is absorbed from the gastrointestinal tract. Eating slows down the rate of absorption, extent of absorption is not changed. About 50% of the active substance is metabolized in the "first passage" through the liver. When used rectally absorption is slower. Time to reach C_max in plasma after oral administration is 2-4 hours depending on the used dosage form, after rectal - 1 h, I.M. administration - 20 min. The concentration of active substance in plasma is a linear function of the applied dose.

Not cumulative. Plasma protein binding is 99.7% (predominantly albumin). Penetrates into synovial fluid, C_max is achieved in 2-4 hours later than in plasma.

To a large extent metabolized to form several metabolites, among which two pharmacologically active, but to a lesser extent than diclofenac.

Systemic clearance of the active substance is about 263 ml / min. T1/2 from plasma is 1-2 h, from synovial fluid - 3-6 h. Approximately 60% of the dose was excreted as metabolites by the kidneys, less than 1% excreted in the urine as unchanged, while the rest is displayed in the form of metabolites with bile.

Why is Fluzone Trivalent Subvirion prescribed?

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of musculoskeletal system (osteochondrosis, osteoarthritis, periartropatii), post-traumatic inflammation of soft tissue and musculoskeletal system (sprains, bruises). Pain in the spine, neuralgia, myalgia, arthralgia, pain and inflammation after surgery or injury, pain in gout, migraine, algomenorrhea, pain with Bursitis, proctitis, colic (biliary and renal), pain in infectious and inflammatory diseases of ENT organs.

For local use: the inhibition of miosis during surgery for cataract prevention of cystoid macular edema associated with removal and lens implantation, inflammatory eye non-infectious nature, post-traumatic inflammation in penetrating and nonpenetrating wound of the eyeball.

Dosage and administration

For oral use for adult single dose is 25-50 mg 2-3 times / 24 h. Frequency of admission depends on the dosage form employed, the severity of the disease and is 1-3 times / 24 h, rectally - 1 times / 24 h, for the treatment of acute conditions or the exacerbation of chronic edema use intramuscular in dose of 75 mg.

For children older than 6 years and adolescents daily dose is 2 mg / kg.

Topical applied at a dose of 2-4 g on the affected area 3-4 times / 24 h.

When used in ophthalmology frequency and duration of administration are determined individually.

The maximum oral daily dose for adults is 150 mg.

Fluzone Trivalent Subvirion ( Panama ) side effects

Digestive system: nausea, vomiting, anorexia, abdominal pain and discomfort in the epigastrium, flatulence, constipation, diarrhea, and in some cases - erosive-ulcerative lesions, gastrointestinal bleeding and perforation; rarely - abnormal liver function. When rectal administration - in isolated cases were observed inflammation of the colon bleeding, exacerbation of ulcerative colitis.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, fatigue, rarely - paresthesia, visual disturbances (blurred, double vision), tinnitus, insomnia, cramps, irritability, tremors, mental disorders, depression.

Hemopoietic system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis.

Urinary system: rarely - renal failure; in predisposed patients may be swelling.

Dermatological reactions: rarely - hair loss.

Allergic reactions: skin rash, itching, when used in the form of eye drops - itching, redness, photosensitivity.

Local reactions: in the place of I.M. introducing possible burning, in some cases - the formation of infiltration, abscess, necrosis of adipose tissue in the rectal administration may be local irritation, the appearance of mucous discharge mixed with blood, painful defecation, when used externally, in rare cases - itching, redness, rash, burning sensation, when applied topically in ophthalmology may be a transient burning sensation and / or temporary blurred vision immediately after instillation.

With long-term topical use and / or drawing on a vast surface of body are possible systemic side effects due to resorptive action of diclofenac.

Contraindications

known hypersensitivity to diclofenac sodium or to any accessory ingredient that is part of the drug diclofenac;

anamnestic information about the attacks of bronchial asthma, urticaria, acute rhinitis associated with the use of aspirin or other NSAIDs;

hemodyscrasia unknown origin;

children under 6 years

pregnancy ;

lactation

increased sensitivity to sulfite (for injection solution).

children under age 15 - tablets of 50 mg to 18 years - injection.

Using during pregnancy and breastfeeding

Use during pregnancy and lactation is possible in cases where the potential benefits for the mother exceeds than the potential risk to the fetus or newborn.

Special instructions

With extreme caution is used in diseases of liver, kidney, gastrointestinal history, dyspepsia, asthma, hypertension, heart failure, after major surgery, as well as elderly patients.

When referring to a history of allergic reactions to NSAIDs diclofenac and sulfites are used only in urgent cases. In the course of treatment requires systematic monitoring of liver function and kidney picture of peripheral blood.

Do not recommended the use for rectal patients with diseases of anorectal region or anorectal bleeding in history. Topical should be applied only to intact skin areas.

Avoid contact with diclofenac in the eye, or on mucous membranes. Patients who use contact lenses, eye drops should be applied no earlier than 5 minutes after removing the lenses.

Not recommended for children under 6 years.

During the period of treatment drugs for systemic use is not recommended alcohol consumption.

During the period of treatment may decrease the speed of psychomotor reactions. With worsening blurred vision after application of eye drops should not be driving and doing other potentially danger activities.

Fluzone Trivalent Subvirion ( Panama ) drug interactions

At simultaneous application with diclofenac antihypertensive drugs may be weakening their actions.

There are few reports on the occurrence of seizures in patients taking both NSAIDs and antibacterial drugs quinolic series.

At simultaneous application with GCS and increased risk of side effects from the digestive system.

With simultaneous use of diuretics may decrease diuretic effect. With the simultaneous use of potassium-sparing diuretics may increase the concentration of potassium in the blood.

With simultaneous use with other NSAIDs may increase the risk of side effects.

There are reports of hypoglycemia or hyperglycemia in patients with diabetes who engaged in diclofenac together with hypoglycemic drugs.

When applied simultaneously with acetylsalicylic acid may decrease the concentration of diclofenac in plasma.

Although clinical studies have not found the influence of diclofenac on the action of anticoagulants, describes the individual cases of bleeding when used with diclofenac and warfarin.

With simultaneous use may increase digoxin, lithium, and phenytoin in blood plasma.

The absorption of diclofenac from the gastrointestinal tract is reduced by simultaneous application with kolestiraminom, to a lesser extent - with colestipol.

With simultaneous use may increase the concentration of methotrexate in plasma and increased its toxicity.

With simultaneous application of diclofenac could not affect the bioavailability of morphine, but the concentration of the active metabolite of morphine may be enhanced in the presence of diclofenac, which increases the risk of side effects metabolites of morphine, including respiratory depression.

When applied simultaneously with pentazocine described a case of great convulsions, and rifampicin - may decrease the concentration of diclofenac in plasma, with ceftriaxone - increases excretion of ceftriaxone in bile; with cyclosporine - may increase cyclosporine nephrotoxicity.

Fluzone Trivalent Subvirion in case of emergency / overdose

Symptoms: may cause hypotension, renal failure, convulsions, gastrointestinal irritation or respiratory depression. Treatment: There is no specific antidote. In acute poisoning as soon as possible to stop drug absorption from the gastrointestinal tract. There is indicated gastric lavage, activated charcoal appointment and conduct of other symptomatic and supportive therapy. The use of forced diuresis, dialysis or blood transfusion is not justified because NSAIDs largely associated with serum proteins and possess extensive metabolism.

Storage conditions

In a dry, protected from light place, at temperature not above 25°C.Common expiration date for diclofenac tablets: 3 years.

B :

• Pharmacological action
• Pharmacokinetics
• Why is Fluzone Trivalent Subvirion Xepa-Soul Pattinson prescribed?
• Dosage and administration
• Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson side effects, adverse reactions
• Fluzone Trivalent Subvirion Xepa-Soul Pattinson contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson drug interactions
• Fluzone Trivalent Subvirion Xepa-Soul Pattinson in case of emergency / overdose
• Fluzone Trivalent Subvirion (B ) reviews

Pharmacological action

Fluzone Trivalent Subvirion Xepa-Soul Pattinson is a synthetic antimicrobial drug with broad spectrum bactericidal action. sulfamethoxazole has a bacteriostatic action, which is associated with inhibition of recycling process of PABA and a violation dihydrofolic acid's synthesis in bacterial cells. Trimethoprim inhibits the enzyme that is involved in the metabolism of folic acid converting dihydrofolate to tetrahydrofolate. Thus it is blocked two successive stages of the biosynthesis of purines and therefore nucleic acids that are essential for growth and reproduction of bacteria. High concentrations created in the tissues of the lung, kidney, prostate, cerebrospinal fluid, bile, bones.

Co-trimoxazole is active against gram-positive bacteria: Staphylococcus spp. (including strains of penicillinase producing), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae; gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter spp., Klebsiella spp., Yersinia spp., Vibrio cholerae, Haemophilus influenzae; anaerobic asporogenous bacteria - Bacteroides spp. Co-trimoxazole is active also against Chlamydia spp.

Pseudomonas aeruginosa, Treponema spp., Mycoplasma spp., Mycobacterium tuberculosis and also viruses and fungi are resistant to co-trimoxazole.

Pharmacokinetics

After oral administration Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Meal slows their absorption. Widely distributed in tissues and body fluids. The binding of trimethoprim to plasma proteins is 50%, sulfamethoxazole - 66%. T1/2 of trimethoprim is 8.6-17 hours, sulfamethoxazole - 9-11 hours. Trimethoprim is excreted in the urine in unchanged form (50%) and as metabolites. Sulfamethoxazole also excreted in the urine, mainly unchanged.

Why is Fluzone Trivalent Subvirion Xepa-Soul Pattinson prescribed?

Infectious-inflammatory diseases caused by sensitive to co-trimoxazole microorganisms: respiratory tract infections (including acute and chronic bronchitis, empyema, bronchiectasis, lung abscess, pneumonia, tonsillitis, pharyngitis); urinary tract infections (including gonococcal urethritis), cystitis, pyelonephritis, prostatitis; gastrointestinal infections (including enteritis, typhoid, paratyphoid, dysentery, cholecystitis, cholangitis); infections of skin and soft tissue (including pyoderma, furunculosis, wound infection), septicemia, brucellosis.

Dosage and administration

Individual. Doses of Fluzone Trivalent Subvirion Xepa-Soul Pattinson are given on the basis of sulfamethoxazole. For oral administration for adults and children older than 12 years the average dose is 0.4-2 g every 12 hours (2 times / day), course of treatment - 5-14 days. Orally for children aged 2-5 months - 100 mg 2 times / day; 1-2 years - 100 mg 2 times / day; 3-6 years - 200 mg 2 times / day; 6-12 years at 200-400 mg 2 times / day.

Parenterally administered only in the absence of the possibility of oral administration. IM for adults and children over 12 years - 800 mg every 12 hours; for children aged 6-12 years - 30 mg / kg / day, interval between each dose - 12 hours.

If necessary prescribed IV as drops at 0.8-1.6 g every 12 hours (2 times / day) within 5 days. For children aged 6-12 years are prescribed at 15 mg / kg every 12 hours. Average duration of Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson injection - 30-60 minutes but no more than 1.5 hours. The course of treatment is average 5 days, then if necessary go to oral administration. The maximum oral daily dose for adults is 3.6 g.

Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson side effects, adverse reactions

Digestive system: nausea, vomiting, diarrhea, glossitis, pseudomembranous colitis, cholestatic hepatitis.

Allergic reactions: skin rash, angioedema, Stevens-Johnson syndrome, Lyell's syndrome.

Hemopoietic system: leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia.

Urinary system: crystalluria, hematuria, interstitial nephritis.

Local reactions: phlebitis (when IV injected).

Other: purpura, impaired thyroid function.

Fluzone Trivalent Subvirion Xepa-Soul Pattinson contraindications

Expressed disorders of liver and kidney function, blood diseases, deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation (breastfeeding), hypersensitivity to sulfonamides and trimethoprim.

Using during pregnancy and breastfeeding

Sulfonamides and trimethoprim cross the placenta and excreted in breast milk. They can cause the development of kernicterus and hemolytic anemia in the fetus and newborn. In addition increases the risk of fatty liver in pregnant women. Therefore the use of co-trimoxazole in pregnancy is contraindicated. If necessary using of co-trimoxazole during lactation breastfeeding should be discontinued.

Special instructions

With careful use of co-trimoxazole in patients with a possible deficiency of folic acid, in allergic reactions in anamnesis, bronchial asthma, disorders of liver, kidney, thyroid gland. When long treatment should be systematically study the peripheral blood, the functional state of liver and kidney.

Elderly patients are recommended the appointment of additional folic acid. During co-trimoxazole treatment should be ensured adequate water pressure.

If the kidney function disorders the dose should be reduced and the intervals between doses increased.

The risk of adverse reactions is increased in elderly patients and patients with AIDS.

When parenteral administration of Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson in patients with renal insufficiency should determine the concentration of sulfamethoxazole in blood plasma every 2-3 days before the regular IM injection. In concentration of 150 ug / ml the treatment should be discontinued until the concentration drops to 120 mcg / ml.

Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson drug interactions

With the simultaneous application of co-trimoxazole effect of anticoagulants of indirect action is greatly enhanced due to slow inactivation of the latter, as well as their release from binding with plasma proteins.

In an application with some sulfonylureas may increase hypoglycemic effect which is associated with an increased concentration of free fraction of co-trimoxazole.

The simultaneous use of co-trimoxazole and methotrexate may increase the toxicity of the latter (in particular to the appearance of pancytopenia) due to its release from binding to plasma proteins.

Influenced butadion, indomethacin, naproxen, salicylates and other NSAIDs may increase the action co-trimoxazole with the development of undesirable effects, since there release of active substances from binding with blood proteins and increase their concentration.

Simultaneous treatment with diuretics and co-trimoxazole increases the risk of thrombocytopenia caused by the latter especially in elderly patients.

In the case of co-administration chloridine with Fluzone Trivalent Subvirion (B ) Xepa-Soul Pattinson antimicrobial effect is enhanced because chloridine inhibits the formation of tetrahydrofolic acid required for the synthesis of nucleic acids and proteins. In turn sulfonamides inhibit the formation of dihydrofolic acid, a precursor of tetrahydrofolic acid. This combination is widely used in the treatment of toxoplasmosis.

Absorption of sulfamethoxazole and trimethoprim at their joint reception with cholestyramine decreases the formation of insoluble complexes, which leads to a decrease in their concentration in the blood.

Fluzone Trivalent Subvirion Xepa-Soul Pattinson in case of emergency / overdose

Symptoms: anorexia, nausea, vomiting, weakness, abdominal pain, headache, drowsiness, hematuria and crystalluria.

Treatment: gastric lavage, fluid management, correction of electrolyte imbalance. If necessary - hemodialysis.

For chronic overdosage is characterized bone marrow suppression (pancytopenia). Treatment and prevention: the appointment of folic acid (5-15 mg daily).